Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–co... by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…Objectives To investigate effects of appropriately and inappropriately dosed apixaban/rivaroxaban versus warfarin on effectiveness and safety outcomes in patients with non-valvular atrial fibrillation (NVAF).Design Cohort study with nested case–control analyses using primary care electronic health records (IQVIA Medical Research Data UK database).Setting UK primary care.Participants Patients aged ≥18 years with NVAF newly prescribed apixaban (N=14 701), rivaroxaban (N=14 288) or warfarin (N=16 175) between 1 January 2012 and 30 June 2018, and followed up to 31 December 2018.Primary and secondary outcome measures Incident cases of ischaemic stroke/systemic embolism (IS/SE) and intracranial bleeding (ICB). Cases were matched to controls on age, sex and OAC naïve status. …”
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The evaluation of safe zones for the corona mortis using a cadaver simulation of the Modified Stoppa approach by Jade Naicker, Zithulele Nkosinathi Tshabalala, Andries Masenge, Obakeng Modisane, Steven Matshidza, Nkhensani Mogale

“…These risks arise from the inadvertent severing of vessels along the pelvic brim, resulting in bleeding, prolonged recovery, or even death. The specific vessels of concern include the corona mortis (CM) anastomosis and aberrant vasculature, which course over the superior pubic ramus. …”
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Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Tr... by Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

“…The secondary outcomes will be the proportion of participants demonstrating complete healing after 7 days and 14 days of treatment, change in pain at or after defecation, cessation of bleeding, and any recurrence during the study period. …”
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自发性脑出血术后早期使用阿司匹林的可能性：来自中国学者的首个脑出血围手术期管理高级别循证依据 Possibility of Early Use of Aspirin after Spontaneous Intracerebral Hemorrhage Surgery: The First High-Level Evidence-Based Evidenc... by 周航，陈高(ZHOU Hang, CHEN Gao)

“…The recently published early-start antiplatelet treatment after neurosurgery in patients with spontaneous intracerebral hemorrhage (E-start) study indicates that for intracerebral hemorrhage patients with a high risk of ischemic events, early initiation of postoperative antiplatelet therapy can bring significant benefits without increasing the risk of bleeding. As the first high-level evidence-based evidence on perioperative management of intracerebral hemorrhage in China, the E-start study is instrumental in improving the treatment and management standards for intracerebral hemorrhage and enhancing patient outcomes.…”
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Undetermined Ruptured Low‐Grade Appendiceal Mucinous Neoplasm Following High‐Energy Blunt Abdominal Trauma Requiring Emergency Laparotomy by Ippei Matsuo, Tetsuya Yumoto, Akari Tsuji, Ryo Tanabe, Toshihisa Matsumura, Mikoto Shimabara, Masaaki Akai, Shoji Takagi, Hiromichi Naito, Atsunori Nakao

“…ABSTRACT Blunt abdominal trauma causing intraperitoneal injury and/or bleeding can be life‐threatening, requiring immediate intervention. …”
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Is It Possible to Achieve Favorable Accelerated Dental Changes with No Periodontal Complications When Retracting Upper Anterior Teeth Assisted by Flapless Corticotomy Compared to T... by Hanin Nizar Khlef, Mohammad Younis Hajeer

“…The values of gingival, papillary bleeding and plaque indices in the TC group were significantly greater than those in the FC group after performing the corticotomy (P<0.001, P<0.003, P=0.002, respectively). …”
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Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma by Koržinek Martha, Ćelap Ivana, Fabijanec Marija, Žanić Tena, Ljubičić Neven, Baršić Neven, Verbanac Donatella, Barišić Karmela, Rajković Marija Grdić

“…Lower hemo globin levels in CRC patients are possibly due to more frequent and excessive bleeding. Higher levels of basophils and eosinophils in CRC patients are indicators of inflammatory reaction, which is linked to CRC.…”
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Bronchotracheal Stenting Management by Rigid Bronchoscopy under Extracorporeal Membrane Oxygenation (ECMO) Support: 10 Years of Experience in a Tertiary Center by Sabrina Meyer, Anne-Sophie Dincq, Lionel Pirard, Sebahat Ocak, Jean-Paul D’Odémont, Philippe Eucher, Benoît Rondelet, André Gruslin, Laurie Putz

“…Only two local complications caused by the cannulation of ECMO were reported, and anticoagulation was adapted to avoid bleeding at the operating site and clot formation in the system. …”
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Predictors of missed hospital appointments in patients with posterior compartment pelvic floor disorders in a tertiary referral centre by Tanzeela Gala, Mehak Saini, Abigail Fernandes, Carlotta Sarzo, Noman Shahzad, Carlene Igbedioh, Alexis Schizas, Linda Ferrari, Alison Hainsworth

“…Missed appointments recorded were: TTAC — 45 (2.2%), BFC — 309 (15.8%), EAUS — 476(24%), PFUS — 484(37.2%) and DP — 432(26.2%).Predictors determined were: Male gender, age <50 years, complaints of rectal pain and bleeding for missing telephone and face-to-face appointments, low socioeconomic status for missing face-to-face appointments, and mixed and other ethnic groups with missing telephone appointments. …”
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Topical Application of Orabase Bromelain Gel Reduces Inflammatory Process, Bone Loss and Steatosis in Experimental Periodontitis by Even Herlany Pereira Alves, Hélio Mateus Silva Nascimento, Luiz Felipe de Carvalho França, Any Carolina Cardoso Guimarães Vasconcelos, Larissa dos Santos Pessoa, Felipe Rodolfo Pereira da Silva, John Arlley Sousa Pinho de Lira, Paulo Roberto Carneiro Gomes, André dos Santos Carvalho, André Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos

“…The clinical parameters of tooth mobility (TM), gingival bleeding index (GBI) and probing pocket depth (PPD) were evaluated and, after euthanasia, gingival and liver tissue were collected by biopsy for biochemical evaluation of myeloperoxidase (MPO), malonaldehyde (MDA), glutathione (GSH) and from the jaws for morphometric analysis of alveolar bone height. …”
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Effectiveness of sacral neuromodulation with 3D-printing and ultrasound localization for treating neurogenic bladder in patients with pelvic structural anomalies by Runze Liu, Yuxuan Zhou, Qiang Hao, Yaoguang Zhang, Peng Zhang, Guoqing Chen, Yong Zhang

“…Metrics compared included the number of punctures, average puncture duration, intraoperative SNS tuning time, effective initial voltage, postoperative testing duration, phase two conversion rates, and the incidence of bleeding and infection. Results: The study group experienced significantly fewer punctures compared to the control group (2.21 ± 0.92 vs 9.29 ± 4.37) (P < 0.01), had a shorter average puncture duration (5.71 ± 2.69 min vs. 28.60 ± 9.69 min) (P < 0.01), and required a lower effective initial voltage (0.87 ± 0.23v vs. 1.38 ± 0.52v) (P < 0.01). …”
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Balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: short- and long-term results from a cohort in Brazil by Fabio Solano de Freitas Souza, Marcelo Gottschald Ferreira, Iury Andrade Melo, Marta Ferreira Leite de Sá, Camila Melo Coelho Loureiro, Rosalvo Abreu, Paulo Henrique Alves de Carvalho, Mateus dos Santos Viana, Valdemar Oliveira Jr, Luiz Eduardo Fonteles Ritt

“…Two deaths were recorded (due to CTEPH progression and gastrointestinal bleeding, respectively). Conclusions: Among this first group of patients treated with BPA in Brazil, there was significant short- and long-term clinical improvement, together with a low frequency of complications.…”
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Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites by Alberto Ferrarese, Valerie Tikhonoff, Edoardo Casiglia, Paolo Angeli, Silvano Fasolato, Diego Faggian, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Patrizia Burra, Marco Senzolo

“…Patients with cirrhosis and refractory ascites, with an indication to start NSBB in primary prophylaxis for variceal bleeding, were enrolled. During two consecutive LVP, while being, respectively, off and on NSBB, cardiac output (CO), systemic vascular resistances (SVR), peripheral vascular resistances (PVR), and plasma renin activity (PRA) were noninvasively assessed. …”
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ULSOSEAL Technique: A Unique Technique to Achieve Hemostasis Using ExoSeal in High-Risk Patients after Common Femoral Artery Puncture by Yohsuke Honda, Shinsuke Mori, Tomoya Fukagawa, Toshihiko Kishida, Takahide Nakano, Shigemitsu Shirai, Masafumi Mizusawa, Kenji Makino, Masakazu Tsutsumi, Norihiro Kobayashi, Masahiro Yamawaki, Yoshiaki Ito

“…There was no incidence of vessel occlusion, pseudoaneurysm, arteriovenous fistula, infection, and secondary bleeding. One patient developed a hematoma (>5 cm in size); however, it occurred before the use of ExoSeal due to side leakage from the inserted sheath. …”
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Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study by Carmen Peral, Alfonso De Lossada Juste, Nadia Lwoff, Nataly Espinoza-Cámac, Miguel Ángel Casado, Tom Burke, Jose Alvir, Sheena Thakkar, Enrico Ferri Grazzi

“…**Background:** Hemophilia is a congenital disorder characterized by deficiency or absence of clotting factor VIII in hemophilia A (HA) or clotting factor IX in hemophilia B (HB), resulting in frequent, repeated, and prolonged spontaneous or traumatic bleeding into joints or soft tissue. Severity is classified by the patient's baseline level of clotting factor activity as mild (>5%-40%), moderate (1%-5%), or severe (<1%). …”
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Stent-graft implantation for late postpancreatectomy hemorrhage after pancreatoduodenectomy by Xiaoye Li, Shibo Xia, Liangxi Yuan, Lei Zhang, Chao Song, Xiaolong Wei, Qingsheng Lu

“…Conclusions: With suitable anatomy, covered stent-graft implantation is an effective and safe treatment option for PPH with various bleeding sites and causes.…”
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Sarcomatous tumor with external iliac vein aneurysm: a rare entity by Tushar Kalekar, Neeha Amit Jhala, Reetika Kapoor, Eshan Chetan Durgi, Karishma Krishnani

“…Case presentation A middle-aged male in his fifties presented to the emergency department with continuous bleeding from a wound over a right inguinal swelling that had been ongoing for four hours. …”
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A Rare Case of Spontaneous Heterotopic Pregnancy at 12&nbsp;weeks of Gestation Following Natural Conception With Literature Review by Wang F, Xu Y, Dong X, Jiang P, Yu QQ

“…An urgent laparoscopic salpingectomy was performed under general anesthesia, revealing a distended right fallopian tube (3.5 cm) with a thickened appearance, bluish-purple discoloration, and a 2 mm rupture with active bleeding surrounded by clots. Histopathological examination confirmed ectopic pregnancy. …”
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Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? by Petr Hoffmann, Michal Balik, Martina Hoffmannova, Jindrich Kopecky, Pavel Ryska, Jana Draganovicova, Petr Dvorak

“…In total, 32 complications (23.2%) were confirmed, 2 of which were pneumothoraces, 29 were minor bleeding that needed only conservative management, and 1 case required angiography and embolization for hemorrhage treatment. …”
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The learning curve for laparoscopic-assisted single-port mediastinoscopic esophagectomy: an analysis of proficiency by Wenhao Li, Xiangfeng Gan, Liangzhan Lv, Yingmeng Wu, Weizhao Huang, Yi Liang, Qingdong Cao

“…Compared with the preliminary stage, the procedure time [275 (250–300) vs 178.5 (161.5–205.0) min, P < .001], bleeding volume [100 (100–200) vs 50 (50–80) mL, P < .001], postoperative hospital stays [15 (13–31) vs 13 (11–17) d, P = .006], and the incidence of anastomotic fistula(20.9% vs 5.2%, P = .017) were significantly lower in the proficiency stage, whereas the number of harvested total lymph nodes [17 (12–23) vs 22 (16–29), P = .002], total mediastinal lymph nodes [7 (5–11) vs 13 (9–18), P < .001] and the rate of recurrent laryngeal nerve lymph node harvest (71.4% vs 96.6%, P < .001) was significantly higher. …”
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