Phase I trial on the safety of olprinone for low central venous pressure management aimed at haemorrhage control during open and laparoscopic hepatectomy: a study protocol by Katsuhiko Uesaka, Yuya Miura, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Yoshiyasu Kato, Takuya Oyakawa, Eiji Ando, Sunao Tamai

“…It is crucial to control bleeding during liver parenchymal transection. Methods to reduce central venous pressure (CVP), such as fluid restriction and the use of vasodilators, are essential for minimising bleeding but can lead to haemodynamic instability. …”
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Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two ca... by Roberto Castelli, Enrico Atzori, Alessandro Palmerio Delitala, Salvatore Antonio Masala, Valentina Micheluzzi, Enrico Ponti, Enrico Ponti, Giuseppe Sanna, Dante Castro, Antonio Gidaro, Mattia Donadoni, Roberto Manetti, Pierluigi Merella, Nicia Isabella Profili, Andrea Maria D'Armini, Gavino Casu, Gavino Casu

“…IntroductionPrimary immune thrombocytopenia is an autoimmune bleeding disorder characterized by variable immune-mediated platelet destruction. …”
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Evaluation and diagnostic approach in patient with Perrault Syndrome by Rachael Christin Nathania, Steven Yulius Usman, Ekarini Aryasatiani

“…Consultation with a pediatric endocrinologist can guide cyclic estrogen and progesterone therapy to induce withdrawal bleeding in adolescents with amenorrhea. Women at risk of ovarian failure should consider donor eggs or oocyte cryopreservation. …”
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Economic and Clinical Impact of Stroke and Warfarin Use for Patients with Non-valvular Atrial Fibrillation by Li Wang, Elyse Fritschel, Onur Baser

“…However, a significantly greater proportion of patients with major and minor bleeding were prescribed a combination of warfarin and antiplatelets than those without these events. …”
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A comprehensive review of massive transfusion and major hemorrhage protocols: origins, core principles and practical implementation by David Silveira Marinho, Denise Menezes Brunetta, Luciana Maria de Barros Carlos, Luany Elvira Mesquita Carvalho, Jessica Silva Miranda

“…Until the beginning of the century, bleeding management was similar in elective surgeries or exsanguination scenarios: clotting tests were used to guide blood product orders and, while awaiting these results, an aggressive resuscitation with crystalloids was recommended. …”
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Proton pump inhibitors versus histamine-2 receptor antagonists for stress ulcer prophylaxis during extracorporeal membrane oxygenation: a propensity score-matched analysis by Hiroki Matsui, Hideo Yasunaga, Hiroshi Tanaka, Yutaka Kondo, Hiroyuki Ohbe, Kiyohide Fushimi

“…The primary outcomes were gastrointestinal bleeding requiring endoscopic haemostasis and in-hospital mortality. …”
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The influence of COVID-19 pandemic on secondary prevention in non-COVID patients with cardioembolic stroke by Lučić-Prokin Aleksandra L., Bogdanović Milan M., Pustahija Tatjana L., Stamenković Marija S.

“…It is crucial to carefully evaluate the possible causes of any ischemic stroke, anticoagulant therapy with direct oral anticoagulants is the mainstay of NVAF management of CS stroke with the dominance of apixaban and bridging therapy. No intracranial bleeding was noted.…”
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Clinical characteristics and treatment outcomes of patients with insulinoma–a single center's experience of 76 cases over a 10-year period by Wei Li, Yali Cheng, Qingyong Ma, Zheng Wu, Zheng Wang

“…The intraoperative suture of high-risk vessels prone to bleeding should be performed if necessary.…”
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System change in practice: A report from the EHC Think Tank workstreams on Access Equity and Future Care Pathways by Gacser Zita, Bourke Steven, Hosszú Dalma, Daniels Susan

“…The European Haemophilia Consortium (EHC) Think Tank was established as a platform for system change to ensure the healthcare ecosystem remains effective and relevant for people with bleeding disorders and other rare diseases. Operating alongside traditional advocacy initiatives, it comprised a series of thematic workstreams in which multiple stakeholders explored and co-designed potential solutions for specific aspects of the healthcare system. …”
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Primary Percutaneous Coronary Intervention in a Patient with Haemophilia A by S. Ashwin Reddy, Stephen P. Hoole, Martin W. Besser

“…Haemophilia A is a rare genetic condition leading to coagulation factor VIII deficiency and thus predisposing to bleeding diathesis. Due to advances in treatment, life expectancy of haemophilia A sufferers is increasing, and the incidence and prevalence of coronary artery disease are rising. …”
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Biliary Sphincter Balloon Dilation: Who, When and How? by K Huibregtse

“…The technique, however, is accepted as the treatment of choice in patients with a bleeding tendency and those in whom the local anatomy is associated with an increased risk of complications with endoscopic sphincterotomy, such as patients with periampullary diverticula or Billroth II gastrectomy.…”
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Severe acute pulmonary embolism in pregnancy by Bhaskar Narayan

“…Low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) can be used during pregnancy and breastfeeding, and systemic thrombolysis can be used in obstetric patients, but there are significant bleeding risks and it should be reserved for high-risk PE with hypotension and shock. …”
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Cutaneous Manifestation of Metastatic Infantile Choriocarcinoma by Timothy Brooks, Laura Nolting

“…Here we describe a case of a female neonate who presented to the ED with a rapidly growing and bleeding vascular lesion to her right cheek. She was eventually diagnosed by biopsy with metastatic choriocarcinoma. …”
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A Rare Association: Hereditary Hemorrhagic Telangiectasia with Liver Cirrhosis Causing Portal Hypertension by Denisse Morales-Tovar, Froylan D. Martínez-Sánchez, Alejandro Gabutti-Thomas, Rodolfo Rivera-Martínez, Jacqueline Córdova-Gallardo

“…The hallmark clinical feature is the presence of recurrent episodes of epistaxis in patients with vascular malformations and a tendency to bleed. We present the case of a 71-year-old woman who presented to the emergency department with upper gastrointestinal bleeding caused by esophageal varices, in conjunction with gastric angiodysplasias. …”
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Retained Placenta Accreta Mimicking Choriocarcinoma by Maureen P. Kohi, Gabrielle A. Rizzuto, Nicholas Fidelman, Jennifer Lucero, Mari-Paule Thiet

“…The patient presented with heavy vaginal bleeding following vaginal delivery complicated by retained products of conception. …”
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System change in practice: A report from the EHC Think Tank workstreams on Registries and Patient Agency by Gacser Zita, Skouw-Rasmussen Naja

“…Recognising the need for system change to ensure equitable access to healthcare for people with bleeding disorders and other rare diseases, the European Haemophilia Consortium (EHC) established a Think Tank to work alongside its traditional advocacy initiatives. …”
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Ulipristal Acetate Efficacy in a Patient with Symptomatic Fibroid and Concomitant Pulmonary Embolism by S. von Wunster, P. D’Oria, L. Colonna, G. Patelli

“…The drug is highly effective in controlling bleeding control and in the recovery of anemia. Here, we report the case of a woman with severe menorrhagia due to a uterine fibroid and with concomitant pulmonary embolism, a serious life-threatening condition. …”
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Haemorrhagic Colitis Caused by Dasatinib by Nishant Patodi, Nidhi Sagar, Zbigniew Rudzki, Gerald Langman, Naveen Sharma

“…Gastrointestinal bleeding appears to be a common adverse event associated with dasatinib therapy. …”
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Pulmonary Endarterectomy in a Patient with Immune Thrombocytopenic Purpura by Bedrettin Yıldızeli, Mehmed Yanartaş, Sibel Keskin, Işık Atagündüz, Ece Altınay

“…Immune thrombocytopenic purpura (ITP) patients are at high risk for bleeding complications regarding surgeries involving cardiopulmonary bypass. …”
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A Rare Congenital Perineal Groove by Enyew Abate

“…Upon examination, there was a vertical perineal wet groove-like unkeratinized erythematous lesion with no bleeding, sign of infection, or inflammation that extends from the posterior vaginal fourchette to the anal rim. …”
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