Cost-reduction strategy to culture patient derived bladder tumor organoids by Mahsa Mollapour Sisakht, Fatemeh Gholizadeh, Shirin Hekmatirad, Tokameh Mahmoudi, Saeed Montazeri, Laleh Sharifi, Hamed Daemi, Shahla Romal, Mohammad Hosein Yazdi, Mohammad Ali Faramarzi, Ahmad Reza Shahverdi, Amir Ali Hamidieh

“…We propose sodium alginate hydrogel scaffold in addition to the fibroblast conditioned medium (FCM)-enriched culture medium that is inexpensive and easily amenable to clinical applications for the culture of bladder cancer PDOs. PDOs grown in sodium alginate and FCM based medium have proliferation potential, growth rate, and gene expression that are similar to PDOs cultured in BME. …”
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Spectral Imaging of Multi-Color Chromogenic Dyes in Pathological Specimens by Merryn V. E. Macville, Jeroen A. W. M. Van der Laak, Ernst J. M. Speel, Nir Katzir, Yuval Garini, Dirk Soenksen, George McNamara, Peter C. M. de Wilde, Antonius G. J. M. Hanselaar, Anton H.N. Hopman, Thomas Ried

“…A pixel‐by‐pixel spectrum‐based color classification is presented of single‐, double‐, and triple‐color in situ hybridization for centromeric probes in T24 bladder cancer cells, and immunocytochemical staining of nuclear antigens Ki‐67 and TP53 in paraffin‐embedded cervical brush material (AgarCyto). …”
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A study on the pharmacovigilance of various SGLT-2 inhibitors by Yanwen Dong, Yangyang Wang, Yangyang Wang, Xiaomei Lan, Xiaomei Lan, Huiyan Zeng, Huiyan Zeng

“…Additionally, overlooked ADRs were identified, including bladder cancer, cholangiocarcinoma, and thrombotic strokes, none of which were reported for canagliflozin.DiscussionWhile shared ADRs for SGLT2is are noted in FDA labeling, monitoring for high-risk populations, such as those with cancers or strokes, remains crucial to prevent deterioration. …”
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A Systematic Review and Meta-Analysis Comparing the Safety and Efficacy of Spinal Anesthesia and Spinal Anesthesia Combined with Obturator Nerve Block in Transurethral Resection of... by Wanxin Deng, Qiang Zhang, Hongmei Yao

“…Transurethral resection of bladder tumors (TURBT) is the main surgical treatment for bladder cancer, but during TURBT, it is easy to stimulate the obturator nerve passing close to the lateral side of the bladder wall and induce involuntary contraction of the adductor muscle group of the thigh innervated by it, which will affect the surgical process and lead to adverse reactions. …”
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Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy by Wassapol Sornthai, Achiraya Teyateeti, Tawatchai Taweemonkongsap, Siros Jitpraphai, Varat Woranisarakul, Kantima Jongjitaree, Katunyou Mahamongkol, Nattaporn Wanvimolkul, Thitipat Hansomwong

“…Abstract This study aimed to investigate the role of myosteatosis, sarcopenia, and perioperative serum biomarkers as independent predictors of major complications within 180 days following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). We retrospectively analyzed of 127 MIBC patients who underwent RC between 2013 and 2023 at a single institution. …”
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The effect of miR-381 on proliferation and prognosis of breast cancer by altering CCNA2 expression by Ming-Gang Cao, Yan Wang, Zhi-Min Yang, Yang Wang, Mei-Qing Wang, Shuai Zhuo, Yan Yang, Chun-Sheng Liu

“…Background MiR-381 can regulate the expression of cyclin A2 (CCNA2) to inhibit the proliferation and migration of bladder cancer cells, but whether miR-381 has the same function in breast cancer is not well know.Methods The over express or silence miR-381 expressing cell lines were constructed by lentivirus infection to reveal the biological functions of miR-381 in vitro. …”
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Utilizing vaginal natural orifice to facilitate bowel manipulation during totally intracorporeal ileal conduit construction: a retrospective cohort study by Kaipeng Jia, Shiwang Huang, Zhun Wang, Yuda Lin, Yiduo Bai, Chong Shen, Zhe Zhang, Zhouliang Wu, Yunkai Qie, Hailong Hu

“…Objective To explore the feasibility and efficacy of the modified technique of totally intracorporeal ileal conduit (IC) construction via vaginal approach following robot-assisted radical cystectomy (RARC) in females.Methods By comparing the perioperative outcomes of the modified technique with extracorporeal urinary diversion (ECUD), 31 females treated for bladder cancer with RARC and IC from May 2020 to December 2023 were retrospectively analyzed and divided into two groups: the ECUD group (10 patients) and the modified intracorporeal urinary diversion (MICUD group) (21 patients). …”
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Research progress on application of digital health interventions in patients with cutaneous ureterostomy (数字健康干预在输尿管皮肤造口患者中的应用进展) by JI Xuebi (吉学碧), WANG Jun (王俊), WANG Ping (王萍), YE Yingao (叶迎奥), WANG Haifeng (王海峰)

“…In the context of radical surgical interventions for bladder cancer, ureterodermostomy has emerged as a relatively safe procedure, characterized by reduced invasiveness, rapid postoperative recovery, and a favorable survival rate. …”
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Noninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications? by Irene Ruiz-Tamayo, Josep Franch-Nadal, Manel Mata-Cases, Dídac Mauricio, Xavier Cos, Antonio Rodriguez-Poncelas, Joan Barrot, Gabriel Coll-de-Tuero, Xavier Mundet-Tudurí

“…To assess prescribing practices of noninsulin antidiabetic drugs (NIADs) in T2DM with several major contraindications according to prescribing information or clinical guidelines: renal failure, heart failure, liver dysfunction, or history of bladder cancer. Methods. Cross-sectional, descriptive, multicenter study. …”
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High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis by Sehhoon Park, Jaeyun Jung, You Jeong Heo

“…Among TMB-H patients, the most common cancer type was colorectal cancer (n=108, 42.0%), followed by gastric cancer (GC; n=49, 19.1%), bladder cancer (n=21, 8.2%), cholangiocarcinoma (n=21, 8.2%), non-small cell lung cancer (n=17, 6.6%), melanoma (n=8, 3.1%), gallbladder cancer (GBC; n=7, 2.7%), and others (n=26, 10.1%). …”
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Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis by Ninet Sinaii, Guru Sonpavde, Amin H Nassar, Min Yuen Teo, Andrea B Apolo, Jonathan E Rosenberg, Giovanni Maria Iannantuono, Elias B A Chandran, Saad O Atiq, Dilara Akbulut, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Gisela Butera, Jonathan A Coleman

“…Meta-analyses were performed if the extracted data were suitable.Results The pooled weighted prevalences of dMMR in bladder cancer (BC) and upper tract UC (UTUC) were 2.30% (95% CI 1.12% to 4.65%) and 8.95% (95% CI 6.81% to 11.67%), respectively. …”
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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…Recent evidence suggests that these drugs may contribute to bladder cancer. This study investigated molecular mechanism underlying effects of metformin and pioglitazone in bladder epithelial carcinogenesis in type 2 diabetes. …”
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Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer by Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker

“…Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated antigens in cancer vaccine development and as adjuvants to dendritic cell-based immunotherapy, because these glycoproteins induce a bias towards Th1 immunity. …”
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Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…In vitro uptake of SFNs by tumor (B16/F10 melanoma and MB49 bladder cancer) or dendritic cells, as well as the presence of OVA-specific T cells in splenic and tumor-infiltrating lymphocytes, were assessed by cytometric analyses. …”
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Stress Reduction in Perioperative Care: Feasibility Randomized Controlled Trial by Haridimos Kondylakis, Irene Alice Chicchi Giglioli, Dimitrios Katehakis, Hatice Aldemir, Paul Zikas, George Papagiannakis, Santiago Hors-Fraile, Pedro L González-Sanz, Konstantinos Apostolakis, Constantine Stephanidis, Francisco J Núñez-Benjumea, Rosa M Baños-Rivera, Luis Fernandez-Luque, Angelina Kouroubali

“…Surgeries included cardiopulmonary and coronary artery bypass surgeries, cardiac valve replacements, prostate or bladder cancer surgeries, hip and knee replacements, maxillofacial surgery, and scoliosis procedures. …”
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The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity by Mustafa Sibai, Sergi Cervilla, Daniela Grases, Eva Musulen, Rossana Lazcano, Chia-Kuei Mo, Veronica Davalos, Arola Fortian, Adrià Bernat, Margarita Romeo, Collin Tokheim, Jordi Barretina, Alexander J. Lazar, Li Ding, Enrique Grande, Francisco X. Real, Manel Esteller, Matthew H. Bailey, Eduard Porta-Pardo, Enrique Grande, Teresa Alonso-Gordoa, Mario Álvarez-Maestro, Elena Andrada, Ainara Azueta, Raquel Benítez Javier Burgos, Daniel Castellano, M. Angel Climent, Mario Domínguez, Ignacio Durán Albert Font, Isabel Galante, Patricia Galván, Juan F. García, Xavier García del Muro, Félix Guerrero-Ramos, Núria Malats, Miriam Marqués, Pablo Maroto, Jaime Martínez de Villarreal, Ane Moreno-Oya, Jesús M. Paramio, Alvaro Pinto, Aleix Prat, Javier Puente, Oscar Reig, Francisco X. Real

“…Finally, we demonstrate interdependent relationships between hallmarks at the junctions of TME and cancer compartments and how they relate to sensitivity to different neoadjuvant treatments in 33 bladder cancer patients from the DUTRENEO trial. In conclusion, our findings may improve our understanding of tumor ecology and help identify new drug biomarkers.…”
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Human head and neck cancer cell lines response to cold atmospheric plasma activated media is affected by the chemistry of culture media by Viviana di Giacomo, Marwa Balaha, Asia Pece, Ilaria Cela, Gianluca Fulgenzi, Giovanna Orsini, Tatiana Spadoni, Tirtha Raj Acharya, Nagendra Kumar Kaushik, Eun Ha Choi, Monica Rapino, Mariangela Mazzone, Gabriella Mincione, Gianluca Sala, Eloisa Sardella, Vittoria Perrotti

“…In addition, cytotoxic effects were also observed on HNC, two bladder cancer models and one breast cancer cell line when considering PTL, paving the way for their application into a clinical setting.…”
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The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

“…Patients and methods The GRACEM study includes patients with non‐metastatic, histologically confirmed, muscle‐infiltrating bladder cancer who underwent RC surgery with curative intent. …”
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Sleep Pattern, Lifestyle Pattern, and Risks of Overall and 20 Types of Cancers: Findings From the UK Biobank Cohort by Yue-Ze Zhao, Yue-Ze Zhao, Wen-Li Zhang, Kai-Wen Zhang, Yong-Qiao He, Wen-Qiong Xue, Da-Wei Yang, Da-Wei Yang, Hua Diao, Hua Diao, Ruo-Wen Xiao, Ying Liao, Qiao-Ling Wang, Qiao-Ling Wang, Wei-Hua Jia, Wei-Hua Jia, Tong-Min Wang

“…Participants with healthy sleep and lifestyle patterns had a lower risk of overall cancer (HR = 0.72, 95% CI = 0.68–0.77), liver cancer (HR = 0.53, 95% CI = 0.31–0.90), bladder cancer (HR = 0.61, 95% CI = 0.47–0.79), lung cancer (HR = 0.22, 95% CI = 0.19–0.27), and colorectal cancer (HR = 0.80, 95% CI = 0.66–0.96) compared to those with unhealthy patterns.ConclusionOur findings highlight the importance of public health education and interventions to improve sleep and other lifestyle behaviours for cancer prevention.…”
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Pomacea canaliculata hemocyanin as a novel natural immunostimulant in mammals by Ignacio Rafael Chiumiento, Ignacio Rafael Chiumiento, María Alejandra Tricerri, María Alejandra Tricerri, María Fernanda Cortéz, Santiago Ituarte, Santiago Ituarte, Julia Tau, Karina Valeria Mariño, Paola Lorena Smaldini, Horacio Heras, Horacio Heras, Marcos Sebastián Dreon, Marcos Sebastián Dreon

“…While the hemocyanin from the marine snail keyhole limpet (KLH), has been widely studied and successfully employed as a carrier/adjuvant in several immunological applications, as well as a non-specific immunostimulant for bladder cancer treatment, few other gastropod hemocyanins have been biochemically and immunologically characterized. …”
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