Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes by Mengmeng Sang, Jia Ge, Juan Ge, Juan Ge, Gu Tang, Qiwen Wang, Jiarun Wu, Liming Mao, Liming Mao, Xiaoling Ding, Xiaorong Zhou

“…For validation, a clinical cohort of patients diagnosed with pancreatic adenocarcinoma was examined using multiplex immunohistochemistry.ResultsWe were able to differentiate between hot and cold tumors in various types of cancer (bladder urothelial carcinoma, pancreatic adenocarcinoma, and cervical squamous cell carcinoma) by analyzing the presence of CD8+ T cells, activated natural killer cells, and M2-type macrophages, as well as the cytolytic activity and T cell proliferation. …”
Get full text

Relationship Between Obstructive Sleep Apnea and Enuresis in Children: Current Perspectives and Beyond by Wang Z, Zhang P, Shi R, Yang S, Liu K, Zhou Z, Li Q

“…Children with OSA may be susceptible to NE due to aberrant humoral factors secretion, sleep-wake disorder, bladder dysfunction, obesity, and psychosomatic factors. …”
Get full text

TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Further evaluation of M6223 is ongoing in combination with the PD-L1 inhibitor avelumab in patients with advanced urothelial carcinoma (JAVELIN Bladder Medley; NCT05327530).Trial registration number NCT04457778.…”
Get full text

Noninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications? by Irene Ruiz-Tamayo, Josep Franch-Nadal, Manel Mata-Cases, Dídac Mauricio, Xavier Cos, Antonio Rodriguez-Poncelas, Joan Barrot, Gabriel Coll-de-Tuero, Xavier Mundet-Tudurí

“…To assess prescribing practices of noninsulin antidiabetic drugs (NIADs) in T2DM with several major contraindications according to prescribing information or clinical guidelines: renal failure, heart failure, liver dysfunction, or history of bladder cancer. Methods. Cross-sectional, descriptive, multicenter study. …”
Get full text

High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis by Sehhoon Park, Jaeyun Jung, You Jeong Heo

“…Among TMB-H patients, the most common cancer type was colorectal cancer (n=108, 42.0%), followed by gastric cancer (GC; n=49, 19.1%), bladder cancer (n=21, 8.2%), cholangiocarcinoma (n=21, 8.2%), non-small cell lung cancer (n=17, 6.6%), melanoma (n=8, 3.1%), gallbladder cancer (GBC; n=7, 2.7%), and others (n=26, 10.1%). …”
Get full text

Fistula Vesiko Vaginalis by Luki Ertandri

“…</p><p class="NoSpacing1"><strong>Kata kunci</strong>: fistula vesiko vaginalis, histerektomi, latzko</p><p class="NoSpacing1"><strong><em>Abstract</em></strong></p><p class="NoSpacing1"><em>Background : Vesica vagina fistula is a part of urogenital fistula wich condition that present fistula between bladder and vagina and make urine mold through vagina.…”
Get full text

Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis by Ninet Sinaii, Guru Sonpavde, Amin H Nassar, Min Yuen Teo, Andrea B Apolo, Jonathan E Rosenberg, Giovanni Maria Iannantuono, Elias B A Chandran, Saad O Atiq, Dilara Akbulut, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Gisela Butera, Jonathan A Coleman

“…Meta-analyses were performed if the extracted data were suitable.Results The pooled weighted prevalences of dMMR in bladder cancer (BC) and upper tract UC (UTUC) were 2.30% (95% CI 1.12% to 4.65%) and 8.95% (95% CI 6.81% to 11.67%), respectively. …”
Get full text

A Case of Cardiac Arrest during C1 Laminectomy for Irreducible Atlantoaxial Subluxation by Yosuke Shibao, Masao Koda, Keita Nakayama, Tomoyuki Asada, Kosuke Sato, Mamoru Kono, Fumihiko Eto, Kentaro Mataki, Hiroshi Kumagai, Katsuya Nagashima, Kousei Miura, Hiroshi Noguchi, Hiroshi Takahashi, Toru Funayama, Tetsuya Abe, Masashi Yamazaki

“…A 60-year-old woman with rheumatoid arthritis presented with neck pain, bilateral finger numbness, and bladder-rectal disturbance. Simple radiograph images showed that the atlantodental interval (ADI) was enlarged to 8 mm, and magnetic resonance imaging revealed severe spinal stenosis at C1. …”
Get full text

Impacts of hexafluoropropylene oxide tetrameric acid (HFPO-TeA) on neurodevelopment and GABAergic signaling in zebrafish larvae by Linlin Wu, Jian Wang, Heyong Ye, Yiyang Yao, Miaoyang Hu, Jie Cheng, Lingcan Kong, Wenwei Liu, Feng Ge

“…It revealed that HFPO-TeA exposure resulted in significant detrimental effects, including adverse impacts on general morphological characteristics, such as eye area, heart rate, and swimming bladder, in zebrafish embryos and larvae. Targeted metabolomics and transcriptomics inquiries clarified that HFPO-TeA exposure reduced the levels of the neurotransmitter gamma-aminobutyric acid (GABA) and downregulated the expression of genes related to the GABA pathway. …”
Get full text

Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer by Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker

“…Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated antigens in cancer vaccine development and as adjuvants to dendritic cell-based immunotherapy, because these glycoproteins induce a bias towards Th1 immunity. …”
Get full text

Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…In vitro uptake of SFNs by tumor (B16/F10 melanoma and MB49 bladder cancer) or dendritic cells, as well as the presence of OVA-specific T cells in splenic and tumor-infiltrating lymphocytes, were assessed by cytometric analyses. …”
Get full text

Application of raman spectroscopy in the non-invasive diagnosis of urological diseases via urine by Ailiyaer Ainiwaer, ShuWen Sun, Ayinuer Bohetiyaer, Yuchao Liu, Yufeng Jiang, Wentao Zhang, JingCheng Zhang, Tianyuan Xu, Hanyang Chen, Xudong Yao, Chengyou Jia, Yang Yan

“…Methods: We searched PubMed, Web of Science, and Google Scholar using 'raman,' 'bladder,' 'kidney,' 'prostate,' 'cancer,' 'infection,' 'stone or urinary calculi,' and 'urine or urinary,' along with 'AND' and 'OR' to refine our search. …”
Get full text

The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity by Mustafa Sibai, Sergi Cervilla, Daniela Grases, Eva Musulen, Rossana Lazcano, Chia-Kuei Mo, Veronica Davalos, Arola Fortian, Adrià Bernat, Margarita Romeo, Collin Tokheim, Jordi Barretina, Alexander J. Lazar, Li Ding, Enrique Grande, Francisco X. Real, Manel Esteller, Matthew H. Bailey, Eduard Porta-Pardo, Enrique Grande, Teresa Alonso-Gordoa, Mario Álvarez-Maestro, Elena Andrada, Ainara Azueta, Raquel Benítez Javier Burgos, Daniel Castellano, M. Angel Climent, Mario Domínguez, Ignacio Durán Albert Font, Isabel Galante, Patricia Galván, Juan F. García, Xavier García del Muro, Félix Guerrero-Ramos, Núria Malats, Miriam Marqués, Pablo Maroto, Jaime Martínez de Villarreal, Ane Moreno-Oya, Jesús M. Paramio, Alvaro Pinto, Aleix Prat, Javier Puente, Oscar Reig, Francisco X. Real

“…Finally, we demonstrate interdependent relationships between hallmarks at the junctions of TME and cancer compartments and how they relate to sensitivity to different neoadjuvant treatments in 33 bladder cancer patients from the DUTRENEO trial. In conclusion, our findings may improve our understanding of tumor ecology and help identify new drug biomarkers.…”
Get full text

Ultrasound investigation at examination of gastro-intestinal tract at combined trauma by A. S. Yermolov, O. A. Alekseyechkina, Ye. S. Vladimirova, G. P. Titova, V. M. Abuchina

“…In 2 patients after operation for splenic rupture and in 2 patients with urinary bladder trauma dynamic smallintestinal ileus was diagnosed with subsequent resolution according to clinical and ultrasound data after conservative treatment. …”
Get full text

The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

“…Patients and methods The GRACEM study includes patients with non‐metastatic, histologically confirmed, muscle‐infiltrating bladder cancer who underwent RC surgery with curative intent. …”
Get full text

Comparison of fluorescence in situ hybridization (FISH) and urine cytology in diagnosing urothelial carcinoma: a single-center retrospective cohort study by WANG Zhiting, ZHU Xiaoli

“…Methods: This study included patients who underwent transurethral resection of bladder tumor (TURBT) from January 2022 to December 2023 and approved by Ethics Commetce of Fudan Univesity Shanghai Cancer Center, No.: 050432-4-2307E) that met the inclusion and exclusion criteria. …”
Get full text

Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives by Ka Zhang, Yi-Wen Zhu, Ao-Qi Tang, Ze-Tao Zhou, Yi-Lun Yang, Zi-Hui Liu, Yan Li, Xiao-Yi Liang, Zhi-Fen Feng, Jun Wang, Tong Jiang, Qi-Ying Jiang, Dong-Dong Wu

“…In fact, 3-MST is overexpressed in many tumors including human colon cancer, lung adenocarcinoma, and bladder urothelial carcinoma. But it is also lowly expressed in hepatocellular carcinoma. …”
Get full text

THE ORGANIZATION WORKS TO IMPROVE THE CLINICAL AND ECONOMIC OUTCOMES OF CARE FOR PROSTATE CANCER by O. I. Apolikhin, A. V. Sivkov, I. V. Chernishov, M. I. Katibov, O. V. Zolotukhin, I. A. Shaderkin, S. A. Leonov, D. A. Vojtko, M. Y. Prosyannikov

“…In case of identification of risk groups for prostate cancer, patients were sent to the urologist at the place of residence, which is conducting special examinations (FRA, ultrasound of the kidneys, bladder, TRUS, UFW), forming a risk group for verification of diagnosis. …”
Get full text

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

“…., abdominal aortic aneurysm and bladder cancer co-occurred in primary care but were not genetically correlated (Odds-Ratio = 2.23 [2.09:2.37], Rg = 0.04 [−0.20:0.28]) and schizophrenia and fibromyalgia were less likely to co-occur together in primary care but were positively genetically correlated (OR = 0.84 [0.75:0.94], Rg = 0.20 [0.11:0.29]). …”
Get full text

Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…OncoSeek reported the lowest overall sensitivity across all cancer types (47.4%), and CancerenD24 reported the lowest sensitivity in detecting bladder cancer (38.0%). By stage, OverC and SeekInCare reported a sensitivity of 35.4% and 50.3%, respectively, for stage I cancer. …”
Get full text