Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry by Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich, Feng Yang

“…The developed method offers a valuable tool to streamline the site-specific glycosylation analysis of glycoproteins, which is particularly important for the expanding landscape of novel therapeutic formats in the biopharmaceutical industry.…”
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Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions by Ajam Uddin, Shimul Halder, Nandita Deb, Harinarayan Das, Madhabi Lata Shuma, Ikramul Hasan, Manik Chandra Shill, Syed Shabbir Haider

“…This study aims to improve the biopharmaceutical, mechanical, and tableting properties of a poorly soluble drug, ibuprofen (IBP), by preparing amorphous solid dispersion (ASD) followed by a sustained-release tablet formulation. …”
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Enhancing Virus Filter Performance Through Pretreatment by Membrane Adsorbers by Solomon Isu, Shu-Ting Chen, Raheleh Daneshpour, Hironobu Shirataki, Daniel Strauss, Andrew L. Zydney, Xianghong Qian, Sumith Ranil Wickramasinghe

“…Virus filtration is used to ensure the high level of virus clearance required in the manufacture of biopharmaceutical products such as monoclonal antibodies. …”
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Restructuring of Global Pharmaceutical Supply Chains after COVID-19 by N. A. Volgina

“…Thus, in the production of high-tech biopharmaceutical goods, the most needed strategies will be regionalization and globalization of the chain links, while in the production of essential pharmaceutical goods, the strategy of localization and import substitution will be very successful (especially in the short term). …”
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Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights by Juan Li, Xuan Wang, Li Zhou, Jun Guo, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xiangyong Gu, Binlei Liu, Hui Tian, Han Hu

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From Bitter to Sweet: a preliminary study towards a patient-friendly Praziquantel dosage form by Zanolla, Debora, Bertoni, Serena, Passerini, Nadia, Albertini, Beatrice, Zingone, Guglielmo, Perissutti, Beatrice

“…Therefore, this research highlights the possibility of using binary premixes of PZQ and sweeteners in order to obtain an increase in the biopharmaceutical and organoleptic properties of the anthelmintic drug, underlining also the need for a careful screening of sweetener to design a PZQ patient-friendly dosage form.…”
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Cultivable Actinobacteria First Found in Baikal Endemic Algae Is a New Source of Natural Products with Antibiotic Activity by Denis V. Axenov-Gribanov, Daria V. Kostka, Ulyana А. Vasilieva, Zhanna M. Shatilina, Maria E. Krasnova, Ekaterina V. Pereliaeva, Elena D. Zolotovskaya, Maria M. Morgunova, Olga O. Rusanovskaya, Maxim A. Timofeyev

“…The large number of rare and active strains associated with the endemic alga D. baicalensis could be the promising sources for biopharmaceutical and biotechnological developments and discovery of new natural compounds.…”
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Formulation of Cefdinir Ternary Solid Dispersion and Stability Study under Harsh Conditions by Naamaa A. Naama, Ghaidaa S. Hameed, Dalya Basil Hanna, Zainab H. Mahdi

“… Cefdinir (CEF) is classified as a third-generation cephalosporin within class IV of the Biopharmaceutical Classification System (BCS). Cefdinir has low solubility and permeability, which may reduce oral bioavailability.   …”
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Targeted CQA analytical control strategy for commercial antibody products: Replacing ion-exchange chromatography methods for charge heterogeneity with multi-attribute monitoring by Adam R. Evans, Joseph Mulholland, Michael J. Lewis, Ping Hu

“…Peptide mapping with mass spectrometry (MS) is an important tool for protein characterization in the biopharmaceutical industry. Historically, peptide mapping monitors post-translational modifications (PTMs) of protein products and process intermediates during development. …”
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Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking by S M Sohag, Sharmin Nur Toma, Md. Niaj Morshed, Md. Al Imran Imon, Md. Monirul Islam, Md. Ibnul Piash, Naznin Shahria, Imran Mahmud

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A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…With the rise of biosimilars in the biopharmaceutical market, it has become crucial to ensure that the biosimilar is at par with the original monoclonal antibody (mAb)in terms of efficacy, safety, and quality. …”
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Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review by Wen Zeng, Dong He, Yifan Xing, Junyu Liu, Nan Su, Chong Zhang, Yi Wang, Xinhui Xing

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Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-<i>co</i>-glycolic Acid (<i>nf</i>PLGA) During Co-Precipitat... by Mohammad Saiful Islam, Somenath Mitra

“…<b>Background/Objectives</b>: The co-formulation of active pharmaceutical ingredients (APIs) is a growing strategy in biopharmaceutical development, particularly when it comes to improving solubility and bioavailability. …”
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Autophagy-Enhancing Properties of <i>Hedyotis diffusa</i> Extracts in HaCaT Keratinocytes: Potential as an Anti-Photoaging Cosmetic Ingredient by Qiwen Zheng, Xiangji Jin, Trang Thi Minh Nguyen, Eun-Ji Yi, Se-Jig Park, Gyeong-Seon Yi, Su-Jin Yang, Tae-Hoo Yi

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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

“…The NMR methods described here to probe HOS changes are highly reliable and practical in biopharmaceutical characterization.…”
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3D-Printed Tablets of Nifurtimox: In Vitro and In Vivo Anti-<i>Trypanosoma cruzi</i> Studies by Giselle R. Bedogni, Ana Luiza Lima, Idejan P. Gross, Tatiana Prata Menezes, Andre Talvani, Marcilio Cunha-Filho, Claudio J. Salomon

“…<b>Conclusions</b>: The findings of this work showed that hot melt extrusion coupled with 3D printing is a promising alternative for increasing nifurtimox biopharmaceutical properties and an attractive approach for personalized medicine.…”
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Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39 by Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu-Yo Sun, Emily Bian, Aden Weybright, Hong-Ru Chen, Katia Sol-Church, Ukpong B. Eyo, Clare Pridans, Francisco J. Quintana, Simon C. Robson, Pankaj Kumar, B. Jill Venton, Anne Schaefer, Chia-Yi Kuan

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Transcriptomic analysis of Andrias davidianus meat and experimental validation for exploring its bioactive components as functional foods by Changge Guan, Zhenglin Tan, Shucheng Li, Yi Wang, Naoyuki Yamamoto, Chong Zhang, Songjun Wang, Junjie Chen, Xin-Hui Xing

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Enhanced membrane protein production in HEK293T cells via ATF4 gene knockout: A CRISPR-Cas9 mediated approach by Byung-Jo Choi, Ba Reum Kim, Ho Joong Choi, Ok-Hee Kim, Say-June Kim

“…In summary, ATF4 knockout significantly enhances membrane protein production in HEK293T cells, offering potential improvements in biopharmaceutical manufacturing by enabling more efficient protein synthesis. …”
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Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells by Sukannika Tubtimsri, Tiraniti Chuenbarn, Suwisit Manmuan

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