Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress by Juškaitė Vaida, Ramanauskienė Kristina, Briedis Vitalis

“…Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed. Results of biopharmaceutical evaluation in vitro demonstrated that up to 60 % of resveratrol was released from microemulsions within 6 hours under a constant release rate profile. …”
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Posttranslational Modifications and the Immunogenicity of Biotherapeutics by Roy Jefferis

“…These processes are species and cell specific and challenge the biopharmaceutical industry when developing a production platform for the generation of recombinant biologic therapeutics. …”
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Effect of Volume and Renewal of the Storage Media on the Release of Monomer from Dental Composites by Sima Shahabi, Maryam Sayyari, Sima Sadrai, Sara Valizadeh, Hamidreza Hajizamani, Alireza Sadr

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Formulation and Evaluation of Ketoconazole Nano-suspension by Eriska Agustin, Gita Deslia Sari

“…Ketoconazole is included in the Biopharmaceutical Classification System (BCS) II category, where the drug is poorly soluble in water but has high permeability. …”
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Practical solutions for overcoming artificial disulfide scrambling in the non-reduced peptide mapping characterization of monoclonal antibodies by Andrew Kleinberg, Yuan Mao, Ning Li

“…However, conventional digestive strategies used throughout the biopharmaceutical industry have been shown to cause unintentional rearrangement of disulfide connections (disulfide scrambling), thus generating connectivity profiles that do not accurately represent the protein being analyzed. …”
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With great power, comes great responsibility: the importance of broadly measuring Fc-mediated effector function early in the antibody development process by Silvia Crescioli, Shashi Jatiani, Lenny Moise

“…Building on many years of progress, the biopharmaceutical industry is now advancing innovative research and development by exploring new targets and new formats and using antibody engineering to fine-tune functions tailored to specific disease requirements. …”
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Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

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Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling by Da-Wei Yeh, Li-Rung Huang, Ya-Wen Chen, Chi-Ying F. Huang, Tsung-Hsien Chuang

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Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations by Amber R. Wesner, Marcia L. Brackbill, Larissa L. Coyle, Robert S. Kidd

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Purification, structural elucidation, and in vitro antitumor effects of novel polysaccharides from Bangia fuscopurpurea by Jingna Wu, Xiaoting Chen, Kun Qiao, Yongchang Su, Zhiyu Liu

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Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b by Shuang Liang, Yu-Shuang Sun, Lu Li, Yao Long, Meng Wang, Hou-Zhi Yang, Chun-Di Li, Yan Wang, Shan-Shan Li, Xu Chen, Xin Jin

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Cellulose- and Saccharide-Based Orally Dispersible Thin Films Transform the Solid States and Dissolution Characteristics of Poorly Soluble Curcumin by Helmy Yusuf, Orchidea Meidy Nurintan Savitri, Nadia Natsya Al-Khalifi, Lavinia Gunawan, Brian Karno Chairul, M. Agus Syamsur Rijal, Dewi Isadiartuti, Retno Sari

“…CUR belongs to a biopharmaceutical classification system (BCS) class IV compound that requires improving its water solubility and tissue permeability preceding formulation. …”
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Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration by Chiara G. M. Gennari, Antonella Casiraghi, Francesca Selmin, Francesco Cilurzo

“…Conclusions: Among the formulative variables, the nature and the amount of plasticizer represent the most critical variables to obtain an EuE-based film with satisfying physical and biopharmaceutical properties.…”
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Corrigendum: Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites by Yexun Zhou, Yexun Zhou, Liang Chen, Hui Han, Hui Han, Bohui Xiong, Ruqing Zhong, Yue Jiang, Lei Liu, Haiqing Sun, Jiajian Tan, Xiaowei Cheng, Martine Schroyen, Yang Gao, Yong Zhao, Hongfu Zhang

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Investigating Raman peak enhancement in carboxyl-rich molecules: insights from Au@Ag core-shell nanoparticles in colloids by Junhao Chen, Zhengjia Chen, Tong Liang, Zhennan Zhang, Dahang Cheng, Shurui Liu, Haiyang Liu, Cuicui Liu, Xiaohui Song

“…Surface-enhanced Raman scattering (SERS) is a promising analytical technique with applications in environmental monitoring, healthcare, and the biopharmaceutical industry. While SERS has been successfully applied to molecules such as 4-mercaptobenzoic acid and other thiol- and amine-containing compounds, there is limited research on its detection capabilities for molecules rich in carboxyl groups or unsaturated bonds, such as citric acid. …”
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Comparative Analysis of Phenolic Profiles and Antioxidant Activity in the Leaves of Invasive <i>Amelanchier × spicata</i> (Lam.) K. Koch in Lithuania by Sandra Saunoriūtė, Kristina Zymonė, Mindaugas Marksa, Lina Raudonė

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Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes by Pankaj V. Dangre, Ram D. Phad, Sanjay J. Surana, Shailesh S. Chalikwar

“…In a nutshell, the fast dissolving buccal film for clonidine hydrochloride was successfully developed assisted by QbD approach with markedly improved biopharmaceutical performance as well as patient compliance.…”
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Neuron-Specific Fluorescence Reporter-Based Live Cell Tracing for Transdifferentiation of Mesenchymal Stem Cells into Neurons by Chemical Compound by Do Won Hwang, Hyun Woo Kwon, Jaeho Jang, Hee Jung Jung, Kwang Rok Kim, Dong Soo Lee

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Analysis of the transcriptional activity of model piggyBac transgenes stably integrated into different loci of the genome of CHO cells in the absence of selection pressure by L. A. Yarinich, A. A. Ogienko, A. V. Pindyurin, E. S. Omelina

“…CHO cells are most commonly used for the synthesis of recombinant proteins in biopharmaceutical production. When stable producer cell lines are obtained, the locus of transgene integration into the genome has a great influence on the level of its expression. …”
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Optimization of the intron sequences combined with the CMV promoter increases recombinant protein expression in CHO cells by Ting-Ting Xu, Yan-Fang Wang, Jing-Jia Yuan, Chun-Liu Mi, Shao-Lei Geng, Xiao-yin Wang, Tian-Yun Wang

“…Abstract To meet the requirements of the biopharmaceutical industry, improving the yield of recombination therapeutic protein (RTP) from Chinese hamster ovary (CHO) cells is necessary. …”
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