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Two Novel Compounds Isolated from the Marine Fungal Symbiont of Aspergillus unguis Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells: In vitro Study
Published 2025-01-01“…Muhammad Hasan Bashari,1 Mochamad Untung Kurnia Agung,2 Eko Fuji Ariyanto,1 Laode Muhammad Ramadhan Al Muqarrabun,3 Syefira Salsabila,3 Agus Chahyadi,3 Andi Rifki Rosandy,3 Ervi Afifah,4 Merry Afni,5 Harold Eka Atmaja,5 Tenny Putri,5 Fitria Utami,5 Beginer Subhan,6 Syafrizayanti,7 Yosie Andriani,8 Elfahmi3,9 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3University Center of Excellence for Nutraceuticals, Bioscience and Biotechnology Research Center, Bandung Institute of Technology, Bandung, West Java, Indonesia; 4Graduate School of Master Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 5Biomedical Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 6Department of Marine Science and Technology, Faculty of Fisheries and Marine Science, IPB University, Bogor, West Java, Indonesia; 7Biochemistry Laboratory, Department of Chemistry, Universitas Andalas, Padang, West Sumatera, Indonesia; 8Institute of Climate Adaptation and Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, Malaysia; 9School of Pharmacy, Bandung Institute of Technology, Bandung, West Java, IndonesiaCorrespondence: Muhammad Hasan Bashari, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, West Java, Indonesia, Email bashari@unpad.ac.id Elfahmi, School of Pharmacy, Bandung Institute of Technology, Bandung, West Java, Indonesia, Email elfahmi@fa.itb.ac.idPurpose: A promising feature of marine sponges is the potential anticancer efficacy of their secondary metabolites. …”
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