Impact of partially treated sewage effluent on the water quality of recipient Epie Creek Niger Delta, Nigeria using Malaysian Water Quality Index (WQI) by A Rim-Rukeh, LE Agbozu

“…Impact of partially treated sewage effluent on the water quality of recipient Epie Creek in the Niger Delta area of Nigeria was investigated  experimentally by analysing the physico-chemical and biological characteristics of the surface water samples collected at four (4) sampling stations: at the effluent discharge point (fall out) (SS2), 500 m upstream (SS1), 500m downstream (SS3) and 1000m (SS4) downstream respectively from the point of discharge. …”
Get full text

Numerical Method to Modify the Fractional-Order Diffusion Equation by Yunkun Chen

“…Time or space or time-space fractional-order diffusion equations (FODEs) are widely used to describe anomalous diffusion processes in many physical and biological systems. In recent years, many authors have proposed different numerical methods to solve the modified fractional-order diffusion equations, and some achievements have been obtained. …”
Get full text

Effects of the auxin-dependent degradation of the cohesin and condensin complexes on the repair of distant DNA double-strand breaks in mouse embryonic stem cells by A. V. Smirnov, A. S. Ryzhkova, A. M. Yunusova

“…At the same time, double condensin depletion (Smc2 degron line) demonstrated high biological variability between experiments, complicating the analysis, and requires additional examination in the future. …”
Get full text

Attaching artificial Achilles and tibialis cranialis tendons to bone using suture anchors in a rabbit model: assessment of outcomes by Obinna P. Fidelis, Caleb Stubbs, Katrina L. Easton, Caroline Billings, Alisha P. Pedersen, David E. Anderson, Dustin L. Crouch

“…Artificial tendons were implanted either at the time of (immediate replacement, n = 8), or four/five weeks after (delayed replacement, n = 4) resection of the biological tendon. Hindlimb radiographs of the rabbits were obtained immediately after surgery and approximately every other week until the study endpoint (16 weeks post-surgery). …”
Get full text

THE PROBLEM OF OPENNESS OF THE SYSTEM OF SOCIAL MORALITY by V. V. Nadurak

“…They can be divided into two main groups: the first are those, that have a social origin, and the second – biological. Macro level of morality (moral consciousness) is a new quality in comparison with the control factors. …”
Get full text

Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia In Vitro by Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh

“…Macrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. …”
Get full text

eDNA Metabarcoding, a Promising Tool for Monitoring Aquatic Biodiversity in the Estuaries of Reunion Island (South‐West Indian Ocean) by Lou‐Anne Jannel, François Guilhaumon, Pierre Valade, Pascale Chabanet, Guillaume Borie, Henri Grondin, Philippe Jourand

“…In this context, monitoring the fish's biological sustainability is crucial to ensure the health of these estuarine ecosystems. …”
Get full text

Seasonal Variation in Antimicrobial Activity of Crude Extracts of Psammaplysilla sp. 1 from Phillips Reef, South Africa by Wasswa Cuthbert Kibungu, Justine Fri, Anna-Maria Clarke, Anthony Otigbu, Henry Akum Njom

“…GC-MS revealed several previously reported biologically active compounds such bicyclo[4.2.0]octa-1,3,5-trien-7-ol and phenol, 2,6-dibromo, some of which have been found in plants. …”
Get full text

Pharmacogenomics Tools for Precision Public Health and Lessons for Low- and Middle-Income Countries: A Scoping Review by Borbón A, Briceño JC, Valderrama-Aguirre A

“…Angélica Borbón,1 Juan Carlos Briceño,2 Augusto Valderrama-Aguirre3 1Technological Innovation Management, University of the Andes, Bogotá, Colombia; 2Department of Biomedical Engineering, Director of Technological Innovation Management Programs, University of the Andes, Bogotá, Colombia; 3Department of Biological Sciences, Faculty of Sciences, Director of the Biomedical Research Institute Group, University of the Andes, Bogotá, ColombiaCorrespondence: Augusto Valderrama-Aguirre, Email a.valderramaa@uniandes.edu.coAbstract: Pharmacogenomics is the integration of genomics and pharmacology to optimize drug response and reduce side effects. …”
Get full text

Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…This analysis revealed that 221 biological processes, 82 cellular components, 63 molecular functions, and 36 KEGG pathways were employed to identify three therapeutic candidate genes, including CDC20, DLGAP5, and KIF20A. …”
Get full text

Multi-omics mechanical analysis of gut microbiota, carboxylic acids, and cardiac gene expression interaction triggering diabetic cardiomyopathy by Meixin Shi, Bingbing Zhao, Wenjie Cai, Hui Yuan, Xiao Liang, Zhitao Li, Xinyu Liu, Ye Jin, Xi Liu, Can Wei

“…To sum up, type 2 diabetes mellitus (T2DM) can upregulate the expression of partial cardiac genes through the levels of serum short-chain CAs affected by gut microbiota, thus playing a role in the occurrence and development of diabetic cardiomyopathy (DCM).IMPORTANCEOur research results clearly link the changes in heart genes of T2DM and normal mice with changes in serum metabolites and gut microbiota, indicating that some genes in biological processes are closely related to the reduction of protective microbiota in the gut microbiota. …”
Get full text

Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

“…GO analysis of 14 potential targets revealed their primary involvement in biological processes such as the endoplasmic reticulum unfolded protein response, ER-nucleus signaling pathway, and fibroblast apoptotic process. …”
Get full text

TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma by Ziqing Yu, Lihua Zhong, Wangyang Tang, Wenfang Zhang, Ting Lin, Weifeng Zhu, Gang Chen, Jianchao Wang

“…Abstract Background 5-Hydroxymethylcytosine (5hmC) modification represents a significant epigenetic modification within DNA, playing a pivotal role in a range of biological processes associated with various types of cancer. …”
Get full text

IL1RN and PRRX1 as a Prognostic Biomarker Correlated with Immune Infiltrates in Colorectal Cancer: Evidence from Bioinformatic Analysis by Qi Wang, Xufeng Huang, Shujing Zhou, Yuntao Ding, Huizhi Wang, Weiye Jiang, Min Xu

“…The Molecular Complex Detection (MCODE), Biological Network Gene Oncology (BiNGO) plug-in in Cytoscape, was applied to further screen the DEGs to obtain 15 seed genes, which were IL1RN, GALNT12, ADH6, SCN7A, CXCL1, FGF18, SOX9, ACACB, PRRX1, MZB1, SLC22A3, CNNM4, LY6E, IFITM2, and GDPD3. …”
Get full text

Effects of Gamma Irradiation on the Properties of Hydroxyapatite-Collagen-Chitosan-Mg-ZnO Scaffolds for Bone Tissue Engineering by Tusher -Al-Arafat, Shawon Ahmed, Polash Chandra Karmakar, Umme Salma Zohora, Naznin Akhtar, S. M. Asaduzzaman

“…The physicochemical and biological properties of the scaffolds were evaluated by Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), field emission scanning electron microscopy (FESEM), physical stability (biodegradability, swelling rate, porosity, and density), mechanical properties, biocompatibility, cytotoxicity, and antimicrobial activity against Escherichia coli (ATCC-25922) and Staphylococcus aureus (ATCC-25923). …”
Get full text

Challenges in Diagnosis and Management of SLE in Africa: An Online Survey by Farhanah Paruk, Dzifa Dey, Anisa Mosam, Oluwaytoyin Amira Christina, Mohammed Tikly

“…Glucocorticoids and antimalarials were readily available across all regions, with variable availability of immunosuppressants from 93.7% for methotrexate to 65% for calcineurin inhibitors and only 58.4% for the biologic rituximab. Intensive care units/high care facilities, hemodialysis, and renal transplantation were available to 69.8%, 91.9%, and 56.5% of respondents, respectively. …”
Get full text

Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

“…Because we found no differences between cultivations with and without ZellShield®, we then performed infection experiments using the probiotic Escherichia coli Nissle 1917 as an already established model setup to analyze the impact of technical, interexperimental, and biologic replicates. We demonstrate that interexperimental differences pose the greatest challenge for reproducibility and explain our strategies for addressing these differences. …”
Get full text

Marek's disease virus-1 unique gene LORF1 is involved in viral replication and MDV-1/Md5-induced atrophy of the bursa of Fabricius. by Chenyi Bao, Jun Chu, Qi Gao, Shasha Yang, Xiaoyu Gao, Wenwen Chen, Fuchun Yang, Fei Jiang, Chenxi Tong, Mingyi Lei, Linlin Jiao, Jitong Li, Kexin Wei, Xue Lian, Kai Li, Suresh Kumar Tikoo, Nikolaus Osterrieder, Lorne A Babiuk, Yufeng Li, Yong-Sam Jung, Yingjuan Qian

“…To this end, an infectious bacterial artificial chromosome (BAC) harboring the complete genome of the MDV-1 very virulent strain Md5 was generated, and the rescued rMd5 maintained biological properties similar to the parental virus both in vitro and in vivo. …”
Get full text

Essential oils from Amorpha fruticosa against hepatocellular carcinoma based on network pharmacology by Yixian Liu, Xiaojun Zhang, Jiacong Hao, Ying Zhao, Min Zou, Huiping Chen, Jintao Zhang

“…Although more and more attention has been paid to its biological activity recently, the antitumor activities of the essential oils (EOs) extracted from its leaves (AFLEO) and flowers (AFFEO), and their molecular mechanisms have never been reported up to now. …”
Get full text

Endometrial polyps with bizarre stromal cells: a Benign or a low-grade lesion? by Musen Wang, Fei Gao, Hongkai Zhang, Wenxin Zheng

“…Conclusion The rapid recurrence of the polyp within six months raises new questions about the true biological nature of these entities and the relevance of gene fusions like JAK2::NFIB in their pathogenesis, meriting further investigation.…”
Get full text