Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo by Constance Schmelzer, Mitsuaki Kitano, Gerald Rimbach, Petra Niklowitz, Thomas Menke, Kazunori Hosoe, Frank Döring

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Sex Differences Associated with Primary Biliary Cirrhosis by Daniel S. Smyk, Eirini I. Rigopoulou, Albert Pares, Charalambos Billinis, Andrew K. Burroughs, Luigi Muratori, Pietro Invernizzi, Dimitrios P. Bogdanos

“…There does not appear to be any histological, serological, or biochemical differences between male and female PBC, although the symptomatology may differ, with males being at higher risk of life-threatening complications such as gastrointestinal bleeding and hepatoma. …”
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Changes in Serum Iron, Total Iron Binding Capacity and Transferrin Saturation Percent in Sudanese Females Newly Diagnosed with Breast Cancer at Khartoum Oncology Hospital: A case-... by Rufaida Mustafa Ahmed Mustafa, Nazik Elmalaika Obaid Seid Ahmed Husain

“…Serum iron and transferrin saturation percent may be helpful as biochemical risk markers for breast cancer and TIBC may act as a predictor of disease grade.…”
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Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats by Limin Zhai, Junfei Gu, Di Yang, Wei Wang, Shandong Ye

“…Type 2 diabetic Sprague-Dawley (SD) rats in which diabetes was induced by high-fat diet/streptozotocin (HFD-STZ) were treated with different doses of metformin (150, 300, and 500 mg/kg per day, resp.) for 8 weeks. Various biochemical parameters, kidney histopathology, and renal tissue PCX expression levels were examined. …”
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Molecular study of blaCTX-M profile among uropathogenic Proteus mirabilis isolates by Kadhim Jwad Jamin, Hussein O. M. Al-Dahmosi, Sura Ihsan Abed Jabuk

“…Results: The percentage of samples positive for P. mirabilis based on culture, biochemical, and Gram stain results was 70 (15.5%) of the total 450 samples. …”
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Isolation, identification and optimization of fermentation conditions against Sclerotinia sclerotiorum strains in high salt Doenjang by Xian Zhang, Hongmei Li, Xiaoyu Kang, Seongil Lim, Fanzhu Li

“…By observing culture characteristics and physiological and biochemical tests, three strains were identified through 16S rDNA sequence and phylogenetic tree. …”
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Changes in clinical and imaging variables during withdrawal of heart failure therapy in recovered dilated cardiomyopathy by Brian P. Halliday, Ruth Owen, John Gregson, Ali Vazir, Rebecca Wassall, Zohya Khalique, Amrit S. Lota, Upasana Tayal, Daniel J. Hammersley, Richard E. Jones, Dudley J. Pennell, Martin R. Cowie, John G.F. Cleland, Sanjay K. Prasad

“…Abstract Aims This study aimed to profile the changes in non‐invasive clinical, biochemical, and imaging markers during withdrawal of therapy in patients with recovered dilated cardiomyopathy, providing insights into the pathophysiology of relapse. …”
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Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi by Ahmed M. Elgendy, Mohamed S. Nafie, Zohour I. Nabil, Nahla S. El-Shenawy, Heba N. Gad El-Hak

“…Results: The influence of compounds A and B on electrolytes, biochemical, antioxidant, and inflammatory reactions in induced kidneys underscores their potential therapeutic advantages in alleviating the advancement of kidney stone disease and related complications. …”
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The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats by Xiaoyun Fan, Qing Zhang, Weiling Guo, Qi Wu, Jinpeng Hu, Wenjian Cheng, Xucong Lü, Pingfan Rao, Li Ni, Youting Chen, Lijiao Chen

“…Results showed that oral administration of L. brevis FZU0713 could significantly inhibit obesity, ameliorate the lipid metabolism disorder, including serum/liver biochemical parameters and hepatic oxidative stress in HFD-fed rats. …”
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Study protocol for an observational cohort study of heat stress impacts in pregnancy in The Gambia, West Africa [version 2; peer review: 1 approved, 2 approved with reservations] by Jane E Hirst, Ana Bonell, Abdul Sesay, Leonidas G. Ioannou, Bubacarr Bah, Kris A. Murray, Andy Haines, Sophie E. Moore, David Jeffries, Neil S Maxwell, Ana Vicero-Cabrera, Apolline Saucy, Cally Tan, Emmanuel Okoh, Dorothy Watters, Bakary Sonko, Williams Oluwatosin Adefila, Yahaya Idris, Mam Leigh-Nabou, Jarra Manneh, Andreas Flouris, Sainabou Bojang, Amanda N Sferruzzi-Perri, Andrew Prentice

“…This observational cohort study of 764 pregnant participants based in sub-Saharan Africa, a geographical region at risk of extreme heat events, aims to evaluate the physiological and biochemical changes that occur in pregnancy due to heat stress. …”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

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Multisite Kinetic Modeling of 13C Metabolic MR Using [1-13C]Pyruvate by Pedro A. Gómez Damián, Jonathan I. Sperl, Martin A. Janich, Oleksandr Khegai, Florian Wiesinger, Steffen J. Glaser, Axel Haase, Markus Schwaiger, Rolf F. Schulte, Marion I. Menzel

“…Since pyruvate interacts dynamically and simultaneously with its downstream metabolites, the purpose of this work is the determination of parameter values through a multisite, dynamic model involving possible biochemical pathways present in MR spectroscopy. Kinetic modeling parameters were determined by fitting the multisite model to time-domain dynamic metabolite data. …”
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Plant Antimicrobial Peptides and Their Main Families and Roles: A Review of the Literature by Samuel Salomão Silva de Oliveira, Milena Bellei Cherene, Gabriel Bonan Taveira, Érica de Oliveira Mello, André de Oliveira Carvalho, Valdirene Moreira Gomes

“…In addition, there is a wide repertoire of antimicrobial agents against bacteria, viruses, fungi, and protozoa that can provide a large number of prototype peptides for study and biochemical manipulation. In this sense, plant AMPs stand out because they have a wide range of biological functions against microorganisms and potential applications in medicine and agriculture. …”
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Response Rate and Impact on Lipid Profiles of Obeticholic Acid Treatment for Patients with Primary Biliary Cholangitis: A Meta-Analysis by Yuan Gao, Li Li, Bei Li, Yutao Zhan

“…Obeticholic acid (OCA) is considered the addition of treatment, but the response rate based on commonly referenced biochemical response criteria and lipids’ impact was unclear. …”
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Metabolomics reveal the mechanism for anti-renal fibrosis effects of an n-butanol extract from Amygdalus mongolica by Gao Chen, Chang Hong, Zhou Hong-Bing, Liu Qing, Bai Ying-Chun, Liu Quan-Li, Bai Wan-Fu, Shi Song-Li

“…Sixty male Sprague-Dawley rats were randomly divided into the sham-operated, renal fibrosis (RF) model, benazepril hydrochloride-treated model (1.5 mg kg−1) and BUT-treated (1.75, 1.5 and 1.25 g kg−1) groups and the respective drugs were administered intragastrically for 21 days. Related biochemical indices in rat serum were determined and histopathological morphology observed. …”
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Species pool and local assembly processes drive microbial β diversity in primary forest soils by Debao Li, Jianping Wu

“…Our study emphasizes that not only soil microbial α diversity, but also β diversity attribute to carbon and nitrogen biochemical cycling, which provides new insight for the connections between microbial diversity maintenance and ecosystem functions in old-growth forests.…”
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Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population by Qing Gu, Xue Hu, Jian Meng, Jun Ge, Sui Jun Wang, Xing Zhen Liu

“…TyG, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WtHR) were calculated through anthropometric and biochemical indicators. Associations of TyG, TyG-BMI, TyG-WC, and TyG-WHtR with HUA risk were estimated using Cox regression analyses. …”
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Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl4-induced hepatotoxicity in animal model using physical cold plasma by Masume Farhadi, Farshad Sohbatzadeh, Akbar Hajizadeh Moghaddam, Yasaman Firouzjaei, Cheng Cheng

“…We investigated an ineffective dose of NAC and its parallel effect through the administration of PTN on liver and kidney morphology and several biochemical factors including ALT, AST, and ALP. Additionally, we examined oxidative stress, antioxidant parameters, and glutathione (GSH) levels. …”
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Molecular, Metabolic, and Physiological Responses to Progressive Biotic Stress Caused by Cucumber Mosaic Virus and Turnip Mosaic Virus in Saffron by Marzieh Shamshiri, Conchi Sánchez, Saleta Rico, Ali Mokhtassi-Bidgoli, Mahdi Ayyari, Hassan Rezadoost, Masoud Shams-Bakhsh

“…To elucidate the influence of viral stress on the quality of saffron, morphological, physiological, biochemical, and molecular indexes were assessed. Under the stress of both viruses, typical viral symptoms appeared. …”
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Melasma management: Unveiling recent breakthroughs through literature analysis by Darshan Kumar R, Richa Sood, Prashant Tiwari

“…Research leveraging histological analyses, genetic profiling, and biochemical assays has elucidated novel therapeutic targets, including oxidative stress pathways and inflammatory mediators. …”
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