Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes by Jordan Greaves, Giordano Pula

“…Both platelet haemostatic activity leading to thrombus formation and their participation to inflammatory processes are stimulated by the biochemical conditions associated with DM. We also present evidence on how DM affect the efficacy of existing therapeutic treatments for thrombosis and, by converse, how antidiabetic drugs may affect platelet function and the haemostasis/thrombosis balance. …”
Get full text

The influence of ergonomic factors on the work conditions of paramedics during the rescue of trauma patients in an ambulance by Daniel Celiński, Sylwia Bęczkowska, Iwona Grabarek, Katarzyna Grzybowska, Zuzanna Zysk, Tadeusz Miłowski, Krzysztof Marek Mitura, Sławomir Dariusz Szajda

“…Introduction: The risk factors encountered in the work of paramedics include ergonomic, physical, psychological, and biochemical factors. This study identifies discomforts experienced by paramedics during medical procedures in ambulances, emphasizing their negative impact on musculoskeletal load and forming the basis for ergonomic and organizational recommendations. …”
Get full text

Spiral Fracture in Young Infant Causing a Diagnostic Dilemma: Nutritional Rickets versus Child Abuse by Sonia Kaushal, Manish Raisingani, Raphael David, Bina Shah

“…Additionally, the mother was noncompliant with prenatal vitamins, exclusively breastfeeding without vitamin D supplementation, and had markedly low vitamin D levels 15 weeks postpartum. The biochemical data and history were consistent with rickets. …”
Get full text

Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy by Moisés Blanco Calvo, Angélica Figueroa, Enrique Grande Pulido, Rosario García Campelo, Luís Antón Aparicio

“…In this paper, we compile the most significant data available about biochemical and biological properties of sugar transporters in normal tissues and we review the available information about sugar carrier expression in different types of cancer. …”
Get full text

Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions. by Miguel Ángel Pérez-Castro, Hasier Eraña, Enric Vidal, Jorge M Charco, Nuria L Lorenzo, Nuno Gonçalves-Anjo, Josu Galarza-Ahumada, Carlos M Díaz-Domínguez, Patricia Piñeiro, Ezequiel González-Miranda, Samanta Giler, Glenn Telling, Manuel A Sánchez-Martín, Joseba Garrido, Mariví Geijo, Jesús R Requena, Joaquín Castilla

“…By employing this PMSA methodology and introducing an isoleucine residue at position 108 in mouse PrP, we successfully generated recombinant murine prion strains with distinct biochemical and biological properties. Our study aimed to explore the influence of a polyanionic cofactor in modulating strain selection and infectivity in de novo-generated synthetic prions. …”
Get full text

Mitochondrial Dysfunction and Sirtuins: Important Targets in Hearing Loss by Lingjun Zhang, Zhengde Du, Shusheng Gong

“…These deacetylases regulate diverse cellular biochemical activities. Recent studies have revealed that mitochondrial sirtuins, especially SIRT3, modulate ROS levels in hearing loss pathologies. …”
Get full text

Taxonomy and Polyphasic Characterization of Alkaline Amylase Producing Marine Actinomycete Streptomyces rochei BTSS 1001 by Aparna Acharyabhatta, Siva Kumar Kandula, Ramana Terli

“…A comprehensive study of morphological, physiological parameters, cultural characteristics, and biochemical studies was performed. The presence of iso-C15 : 0, anteiso-C15 : 0, iso-C16 : 0, and anteiso-C17 : 0 as the major cellular fatty acids, LL-diaminopimelic acid as the characteristic cell wall component, and menaquinones MK-9H(6) and MK-9H(8) as the major isoprenoid quinones is attributed to the strain BTSS 1001 belonging to the genus Streptomyces. …”
Get full text

Clinical Features and Severity of Leptospirosis Cases Reported in the Hawke’s Bay Region of New Zealand by Paul Sellors, Rebecca F. Watson, Rachel Bate, Gemma L. Bentham, Kathryn Haigh

“…Most common presenting symptoms were pyrexia (93%), myalgia, and headache (both 86%). 93% of patients worked in the farming or meat industries. The most common biochemical abnormalities were elevated CRP (100%) and abnormal urinalysis (93%). …”
Get full text

In Silico Evolution of Gene Cooption in Pattern-Forming Gene Networks by Alexander V. Spirov, Marat A. Sabirov, David M. Holloway

“…Finally, we comment on how a differential equations (in contrast to Boolean) approach is necessary for addressing realistic continuous variation in biochemical parameters.…”
Get full text

Microbial-Induced Carbonate Precipitation: A Review on Influencing Factors and Applications by Junhui Zhang, Xiuzhi Shi, Xin Chen, Xiaofeng Huo, Zhi Yu

“…Because microbial mineralization involves a series of biochemical and ionic chemical reactions, there are many reaction steps in the solidification process and the solidification effect of MICP is restricted and affected by many factors. …”
Get full text

Modulating gene expression as a strategy to investigate thyroid cancer biology by Diego Claro de Mello, Joice Moraes Menezes, Antonio Tarelo Freitas de Oliveira, Marcella Maringolo Cristovão, Edna Teruko Kimura, Cesar Seigi Fuziwara

“…This strategy has evolved methodologically due to advances in cloning approaches, modeling/algorithms in short hairpin RNA (shRNA) design for knockdown efficiency, and biochemical modifications in RNA synthesis, among other developments. …”
Get full text

Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant by John Wilking Einstein, Mustafa Mohd Rais, Mustafa Ali Mohd

“…Different extracts of Cassia was administered to diabetic rats at 250 and 500 mg/kg doses for 21 days. Biochemical parameters like blood glucose, insulin, glycosylated hemoglobin, lipid profile, and serum marker enzymes were determined. …”
Get full text

Effects of Dietary Pediococcus acidilactici and Isomaltooligosaccharide on Growth Performance, Immunity, and Antioxidant Defense in Juvenile Common Carp by Milad Maniat, Amir Parviz Salati, Nasim Zanguee, Seyed Mohammad Mousavi, Seyed Hossein Hoseinifar

“…The results indicated that the diet containing 1 g/kg PA and 5 g/kg IMO significantly increased the fish growth performance and decreased the feed conversion ratio (p<0.05). Overall, blood biochemical parameters, serum (lysozyme, complements C3 and C4) and mucosal (protein, total immunoglobulin, and lysozyme) immune responses, and antioxidant defense of fish also improved in the PA-IMO5 group (p<0.05). …”
Get full text

Serum High-Density Lipoprotein Cholesterol Concentrations in Pancreatic Ductal Adenocarcinoma and Its Association With Histological Grade in a Chinese Population by Ying-Ying Cao PhD, Xiao-Jing Lv MD, Hui Li PhD, Li-Chao Qian PhD, Hai-Peng Si MD, Yuan Li PhD, Kai Guo PhD, Shuai Ren PhD, Zhong-Qiu Wang MD

“…Clinical data, blood biochemical results, imaging features, and pathological details of the patients were collected, such as age, gender, diabetes, hypertension, tumor grade, tumor size and location, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA). …”
Get full text

Tyrosinase Inhibitory Effect and Antioxidative Activities of Fermented and Ethanol Extracts of Rhodiola rosea and Lonicera japonica by Yuh-Shuen Chen, Hua-Chian Liou, Chin-Feng Chan

“…The results indicated that fermentation of Rhodiola rosea and Lonicera japonica can be considered as an effective biochemical process for application in food, drug, and cosmetics.…”
Get full text

Identification and Characterization of Arcanobacterium canis from Companion Animals in Germany and The United Kingdom by Siti Gusti Ningrum, Antonia Kreitlow, Christoph Lämmler, Ellen Prenger-Berninghoff, Christa Ewers, Geoffrey Foster, Madeleine Plötz, Amir Abdulmawjood

“…Both isolates were analyzed using culture methods, biochemical analysis, MALDI-TOF MS, real-time PCR amplification and sequencing of the 16S rRNA gene, and rpoB, gap, and tuf genes. …”
Get full text

Antibacterial Effect of Black Pepper Petroleum Ether Extract against Listeria monocytogenes and Salmonella typhimurium by Wenxue Chen, Hui Tang, Ningxin Jiang, Qiuping Zhong, Yueying Hu, Haiming Chen, Weijun Chen

“…The activities of key metabolic enzymes shed some light on the biochemical mechanism of aglycon cell growth inhibition, indicating that the energetic metabolism of L. monocytogenes and S. typhimurium was markedly influenced by the BPPE. …”
Get full text

Isolation and Characterization of Plant Growth-Promoting Rhizobacteria from Coffee Plantation Soils and Its Influence on Maize Growth by Yasin Ahmed Waday, Ermias Girma Aklilu, Mohammed Seid Bultum, Venkata Ramayya Ancha, Dejene Beyene

“…The findings of the isolates' morphological and biochemical tests showed that JEC3, JEC4, and JEC7 as Bacillus sp., Pseudomonas sp., and Enterobacter sp., respectively. …”
Get full text

Induction of Cell Activation Processes by Low Frequency Electromagnetic Fields by Myrtill Simkó

“…Cell cycle control and signal transduction processes are included to elucidate the biochemical background of possible interactions. Exposure to EMF has been also linked to the incidence of leukemia and other tumors in some epidemiological studies and is considered as “possibly carcinogenic to humans”, but there is no well-established biological mechanism that explains such a relation. …”
Get full text

Regulation of Th1/Th2 cells in asthma development: A mathematical model by Yangjin Kim, Seongwon Lee, You-Sun Kim, Sean Lawler, Yong Song Gho, Yoon-Keun Kim, Hyung Ju Hwang

“…In the present workwe representthe complex network of interactions between cells and molecules by a mathematical model.The model describes the behaviors of cells (Th0, Th1, Th2 and macrophages)and regulatory molecules (IFN-$\gamma$, IL-4, IL-12, TNF-α) in response tohigh, intermediate, and low levels of LPS.The simulations show howvariations in the levels of injected LPSaffect the development ofTh1 or Th2 cell responses through differential cytokine induction.The model also predicts the coexistence ofthese two types of responseunder certain biochemical and biomechanical conditions in the microenvironment.…”
Get full text