Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study by Michele Maddalo, Maddalena Petraroli, Francesca Ormitti, Alice Fulgoni, Margherita Gnocchi, Marco Masetti, Eugenia Borgia, Benedetta Piccolo, Emanuela C. Turco, Viviana D. Patianna, Nicola Sverzellati, Susanna Esposito, Susanna Esposito, Caterina Ghetti, Maria E. Street, Maria E. Street

“…Pearson correlation between RFs and auxological, biochemical, and ultrasound data was also computed.ResultsTwo different radiomic parameters, Shape Surface Volume Ratio and Glrlm Gray Level Non-Uniformity, predicted CPP with a high diagnostic accuracy (ROC-AUC 0.81 ± 0.08) through the application of our ML algorithm. …”
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The Role of Cardiopulmonary Exercise Test in IPF Prognosis by Christina Triantafillidou, Effrosyni Manali, Panagiotis Lyberopoulos, Likourgos Kolilekas, Konstantinos Kagouridis, Sotirios Gyftopoulos, Konstantinos Vougas, Anastasia Kotanidou, Manos Alchanatis, Anna Karakatsani, Spyros A. Papiris

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The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives by Liwei Fu, Pinxue Li, Hao Li, Cangjian Gao, Zhen Yang, Tianyuan Zhao, Wei Chen, Zhiyao Liao, Yu Peng, Fuyang Cao, Xiang Sui, Shuyun Liu, Quanyi Guo

“…The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of TE; what most important is that static cell culture on scaffolds cannot simulate the physiological environment required for the development of natural cartilage. …”
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Acute effects on hepatic biomarkers in the freshwater native fish Aequidens metae exposed to polycyclic aromatic hydrocarbons by W. Corredor-Santamaría, I.C. Calderón-Delgado, Z. Arbeli, J.M. Navas, Y.M. Velasco-Santamaría

“…The aim of the present study was to evaluate the hepatic and erythrocyte response in Aequidens metae, a detritivorous fish, exposed to polycyclic aromatic hydrocarbons in terms of morphological, biochemical, and genotoxic changes.METHODS: Juveniles of Aequidens metae were exposed to 50 microgram per gram body weight of beta-naphthoflavone, 100 microgram per gram of naphthalene, 50 microgram per gram of phenanthrene and 10 microgram per gram of benzo[a]pyrene, for 72 hours. …”
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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer by Chen YP, Chiu CF, Wang CN, Lin CC, Shen CR, Yao YC, Kuo YH, Liu SJ

“…Yi-Pin Chen,1,2 Chiao-Fan Chiu,3,4 Chien-Neng Wang,1 Chu-Chi Lin,1 Chia-Rui Shen,5– 7 Yi-Chen Yao,8 Yi-Hua Kuo,8 Shih-Jung Liu8,9 1Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung, 20401, Taiwan; 2School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Pediatrics, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan; 4Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan; 5Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, 33302, Taiwan; 6Department of Ophthalmology, Lin-Kou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 7R&D Center of Biochemical Engineering Technology, Department of Chemical Engineering, Ming Chi University of Technology, New Taipei, Taiwan; 8Department of Mechanical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan; 9Bone and Joint Research Center, Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkou, Taoyuan, 33305, TaiwanCorrespondence: Shih-Jung Liu, Department of Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302, Taiwan, Tel +886-3-2118166, Fax +886-3-2118558, Email shihjung@mail.cgu.edu.twBackground: In clinical practice, imiquimod is used to treat Human Papillomavirus (HPV)-related lesions, such as condyloma and Cervical Intraepithelial Neoplasia (CIN). …”
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Prognostic factors for transplant-free survival in patients with secondary sclerosing cholangitis associated with critical illness by Christoph Schramm, Hartmut Schmidt, Christian Gerges, Alisan Kahraman, Christian M Lange, Jassin Rashidi-Alavijeh, Katharina Willuweit, Georgios Konstantis, Dorsa Ghaffar Loy Moghadam, Alexandra Frey, Nargiz Nuruzade, Moritz Passenberg

“…The primary aim of this study was to identify factors associated with transplant-free survival in SSC-CIP patients using readily available data.Methods A cohort of 47 patients diagnosed with SSC-CIP was retrospectively analysed for clinical, biochemical and endoscopic variables. Kaplan-Meier survival curves, log-rank tests and univariate Cox proportional hazards models were used to assess associations with transplant-free survival. …”
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Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations by Muhammad Usman Shah, Muhammad Usman Shah, Alun Roebuck, Bala Srinivasan, Joanna Kate Ward, Paul Edward Squires, Claire Elizabeth Hills, Kelvin Lee, Kelvin Lee

“…Identifying abnormal levels of common biochemical markers of diabetes, such as capillary blood glucose or glycated haemoglobin (HbA1c) in these patients is important for early diagnosis, which will then allow for timely intervention to improve outcomes. …”
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Photosynthetic Induction Characteristics in Saplings of Four Sun-Demanding Trees and Shrubs by Qiuping Liu, Wei Jin, Liying Huang, Danfeng Wang, Kedong Xu, Yunmin Wei

“…The time required to reach 90% of <i>g</i>_sc (t_gsc90) significantly lagged behind t_A90 among species. Biochemical induction was fast in leaves of <i>Ficus carica</i> L., as about 4 min were needed to reach 90% of <i>V</i>_cmax, while the other species needed 7–18 min. …”
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Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study by Samuel Smith, Peter Sasieni, William Cross, Richard Bryant, Steven Kennish, James Catto, Rachel Hubbard, Simon Faulkner, Rohit Chahal, Mohantha Dooldeniya, Marcus Cumberbatch, Bernard North, Alastair D Lamb, Roseann Kealy, Selina Bhattrai

“…Additional MRI scans and/or biopsies will be performed for biochemical or clinical indications. We aim to recruit 550 men (aged 50 to 75 years) from up to eight sites. …”
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The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) by Wei Xiong, Qinghan Liang, Xiaojie Han, Qiaolu Cheng, Qihang Liu, Xifang Zuo, Huiyu Wang, Huijing He, Guangliang Shan

“…Physical examinations and biochemical tests were carried out, alongside regular yearly health check-ups throughout pregnancy and childhood. …”
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Quantifying the impact of fermented liquid bio formulations, biofertilizers and organic amendments on horticultural and soil nutrient traits of garden pea ( Pisum sativum L.) by Vandana Thakur, Praveen Sharma, Pradeep Kumar, Payal Sharma, Sartaj Ahmad Bhat, Sunny Sharma, Rehan Azmi, Shivender Thakur

“…Method: The present experimentation was carried out to assess the effect of various treatments comprised of fermented liquid bio formulations, biofertilizers, & organic amendments on the horticultural, biochemical, & soil nutrient attributes of garden pea varieties. …”
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Clinical assessment of urinary prostate cancer antigen 3 in Chinese population: a large-scale, prospective and multicenter study by Xuan Shu, Jiaming Wang, Wen Cai, Shen Lin, Jiangfeng Li, Xueyou Ma, Yufan Ying, Yat Sai Terry Wang, Xiao Wang, Hong Chen, Chunyu Jin, Ben Liu, Liping Xie, Jindan Luo

“…In radical prostatectomy specimens, PCA3 scores were significantly associated with high-grade PCa (p = 0.002) and EAU biochemical recurrence risk (p = 0.044), but not extracapsular extension (p = 0.072), seminal vesicle invasion (p = 0.482) and T stage (p = 0.457). …”
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Determinants of Physicochemical Composition of Palm Oil Mill Effluent - Implications on Environment and Bio-digester Treatment Design by E.B. Tambe, A.U. Okonkwo, I. E. Mbuka-Nwosu, C.O. Cookey, E. Agbe, S.C. Onwusa, I.N. Ekpe, U.F. Evuen, J. Okpoghono

“…From a randomly sampled small-scaled mill in each community, and for the lone medium and large-scaled mills, four homogenous samples of POME were collected from sampled small, medium and large-scaled mills for laboratory analysis of potential of hydrogen (pH), dissolved oxygen (DO), biochemical oxygen demand (BOD), chemical oxygen demand (COD), total carbon (TC), total solid (TS), total suspended solid (TSS), total organic carbon (TOC), total nitrogen (TN), total kjeldahl nitrogen (TKN), ammonia nitrogen (NH3-N), Manganese (Mn), Nickel (Ni), Iron (Fe), Copper (Cu), Chromium (Cr), Cadmium (Cd), Potassium (K), total phosphorus (TP), Calcium (Ca), and Magnesium (Mg) using standard methods for wastewater analysis as described in American Public Health Association. …”
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A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria by Xiang Gao, Zixuan Wang, Xiang Li, Xiaoling Zhang, Shengqiang Du, Miaomiao Jia, Dailun Hu, Xianxian Jia, Bin Cong, Yan Zhang, Chunling Ma, Song Zhou, Jun Zhang

“…The new isolate was identified as L. gasseri by the colony morphology, Gram staining, biochemical reactions and confirmed by the 16S rDNA sequencing. …”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…The possible underlying mechanisms for the neuroprotective and anxiolytic activities of SM were explored through biochemical assays and brain histology. Results: Our findings suggest that SM has antioxidant and neuroprotective potential, as evidenced by a decrease in ROS accumulation, Ca2+ overload, mitochondrial membrane potential (MMP) loss, and apoptosis in HT-22 cells subjected to glutamate-induced oxidative stress. …”
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Evaluating cutinase from Fusarium oxysporum as a biocatalyst for the degradation of nine synthetic polymer by Maycon Vinicius Damasceno de Oliveira, Gabriel Calandrini, Clauber Henrique Souza da Costa, Carlos Gabriel da Silva de Souza, Cláudio Nahum Alves, José Rogério A. Silva, Anderson H. Lima, Jerônimo Lameira

“…Furthermore, the phylogenetic analysis demonstrated that the PETase enzyme has a very high similarity with the bacterial cutinase enzyme than with the fungal cutinase, therefore demonstrating that the PETase enzyme from Ideonella sakaiensis can easily be a modified bacterial cutinase enzyme that created a unique feature in biodegrading only the pet polymer through an evolutionary process due to its environment and its biochemical need for carbon. Our data demonstrate that bacterial cutinase enzymes have the same common ancestor as the PETase enzyme. …”
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Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic path... by Hart Mann Alain Youbi Mambou, Simon Pale, Orelien Sylvain Mtopi Bopda, Vanessa Tita Jugha, Nji Seraphin Ombel Musa, Tambong Ako Ojongnkpot, Bertrand Yuwong Wanyu, Raymond Bess Bila, Rashed N. Herqash, Abdelaaty A. Shahat, Germain Sotoing Taiwe

“…Finally, the mice were sacrificed, and the hippocampi were isolated to quantify some biochemical markers of oxidative/nitrosative stress, GABAergic/cholinergic signalling, and BDNF levels in the hippocampus. …”
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ApoB/ApoA-Ι is associated with major cardiovascular events and readmission risk of patients after percutaneous coronary intervention in one year by Jie Zhang, Mengyu Liu, Ju Gao, Xiaowen Tian, Yaru Song, Haibei Zhang, Peng Zhao

“…Patient demographics, medications, and biochemical indicators were recorded upon admission, with one-year follow-up post-operation. …”
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Foxtail millet supplementation improves glucose metabolism and gut microbiota in rats with high-fat diet/streptozotocin-induced diabetes by Xin Ren, Linxuan Wang, Zenglong Chen, Min Zhang, Dianzhi Hou, Yong Xue, Xianmin Diao, Ruihai Liu, Qun Shen

“…Specifically, we fully assessed the blood biochemical profiles, pancreatic histopathology, insulin-glucagon immunofluorescence, short-chain fatty acids, and gut microbiota composition of rats with HFD/STZ-induced diabetes before and after FM supplementation. …”
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Effects of Different Molasses Levels and Slow-Release Urea Combinations on Growth Performance, Serum Biochemistry, Rumen Fermentation, and Microflora of Holstein Fattening Bulls by Zhiyuan Xu, Shuaihong Li, Fangzhou Yu, Yinghao Huang, Tao Xie, Hanbing Bian, Longfei Lv, Yapeng Hu, Ruoran Tao, Caiyun Fan, Sijia Liu, Jianbo Cheng

“…The results of the study showed that the MMU had an outstanding performance, with a 13.3% increase in average daily weight gain compared with the control group, a significant decrease in feed conversion ratio (<i>p</i> < 0.05), and a significant increase in apparent digestibility of crude protein (<i>p</i> < 0.05). In terms of serum biochemical indices, blood ammonia and alanine aminotransferase (ALT) concentrations were significantly higher in the MMU than in the CON (<i>p</i> < 0.05). …”
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