Unveiling <i>DENND2D</i> as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis by Chi-Fen Chang, Lih-Chyang Chen, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

“…<b>Background:</b> Prostate cancer is a major global health burden, with biochemical recurrence (BCR) following radical prostatectomy affecting 20–40% of patients and posing significant challenges to prognosis and treatment. …”
Get full text

Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept by Jingjing Li, Yanzhao Zhang, Mingyue Wei, Junjie He, Huifeng Ma, Zilong Chen, Jiajia Duan, Chuanxin Liu

“…Results: The rats presented different degrees of diarrhoea, body surface bruising, and petechiae, and the serum biochemical results revealed significant changes in the activities of the oxidative stress indicators SOD and MDA and the levels of the inflammatory indicators TNF-α and IL-1β. …”
Get full text

Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…The levels of fasting blood glucose (FBG), triglyceride (TG) and total cholesterol (TC) were detected by automatic biochemical analyzer, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. …”
Get full text

Hubungan Kadar Hemoglobin Ibu Hamil Trimester III Dengan Berat Bayi Lahir di Kota Pariaman by Anggi Setiawan, Nur Indrawaty Lipoeto, Amirah Zatil Izzah

“…Kesimpulan: penelitian ini tidak ditemukan adanya hubungan kadar hemoglobin ibu hamil trimester III dengan berat bayi lahir di kota Pariaman (p &gt; 0,05)<br />Kata kunci: Kadar hemoglobin, berat bayi lahir, ibu hamil<br />Abstract<br />Introduction : Hemoglobin level is biochemical indicator to determine the nutrition status of pregnant women. …”
Get full text

The relationship between kidney function and cardiometabolic risk factors, anthropometric indices, and dietary inflammatory index in the Iranian general population: a cross-section... by Samaneh Madani, Seyed Jalil Masoumi, Afsane Ahmadi, Morteza Zare, Najmeh Hejazi, Sahar Foshati

“…In this cross-sectional study, renal function was evaluated using serum creatinine (sCr), blood urea nitrogen (BUN), and estimated glomerular filtration rate (eGFR). Biochemical indices including sCr, BUN, fasting blood sugar (FBS), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) were measured using standard laboratory methods. eGFR was calculated using the Modification of Diet in Renal Disease formula. …”
Get full text

Functional Characteristics and Lipid Lowering Activity of Auricularia heimuer Soluble Dietary Fiber by Xueyu SHANG, Heriban MEI, Ling SU, Qi WANG

“…The obese animal model was constructed by high fat diet (HFD) C57BL/6J mice, and treated with A. heimuer soluble dietary fiber. The body weight, biochemical indexes, and pathological changes of liver tissue and adipose tissue of HSDF treated obese mice were evaluated, and its lipid-lowering efficacy in obese mouse model was explored. …”
Get full text

Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) by Nuwadatta Subedi, Sunita Ranabhat, Sanjib Mani Regmi, Mukesh Mallik, Dela Singh, Shree Krishna Shrestha, Bandana Gurung, Arjun Bhattarai, Madan Prasad Baral, Sudhir Raman Parajuli, Ramchandra Bastola, Junu Shrestha, Sahisnuta Basnet, Eva Gauchan, Sabita Paudel

“…The specimens will undergo standard histopathological, microbiological, biochemical, and molecular tests. The “Cause of Death Panel” will finalize MITS informed cause of death following the customized protocol for the project and the cause so derived will be compared with that obtained by the review of deaths by the MPDSR committees of the hospitals. …”
Get full text

Patterns and predictors of mortality in a semi-urban population-based cohort in Sri Lanka: findings from the Ragama Health Study by Anuradhani Kasturiratne, Dileepa Senajith Ediriweera, Madunil Anuk Niriella, Hithanadura Janaka de Silva, Arunasalam Pathmeswaran, Shamila Thivanshi De Silva, Uthuru Beddage Thulani, Anuradha Supun Dassanayake, Arjuna Priyadarsin De Silva, Sureka Chackrewarthy, Udaya Ranawaka, Norihiro Kato, Ananda Rajitha Wickremasinghe

“…Objective To describe patterns and predictors of mortality in a semi-urban population in Sri Lanka.Design A prospective population-based cohort study.Setting Ragama Medical Officer of Health area in the Gampaha district, Sri Lanka.Participants Adults between 35 and 64 years of age were recruited using an age stratified random sampling technique in 2007.Measures At baseline, we recorded socio-demographic, lifestyle, anthropometric, biochemical and clinical data of the participants. Over 10 years, we obtained the cause and date of death from the death registration documents of deceased participants. …”
Get full text

Chemokines Profiling of Patients with Preterm Birth by Piotr Laudanski, Adam Lemancewicz, Pawel Kuc, Karol Charkiewicz, Barbara Ramotowska, Malgorzata Kretowska, Elwira Jasinska, Grzegorz Raba, Katarzyna Karwasik-Kajszczarek, Janusz Kraczkowski, Tadeusz Laudanski

“…Defining their potential as biochemical markers of preterm birth requires further investigation on larger group of patients.…”
Get full text

Modelling and Analysis of Bioretention Systems for Removal of Stormwater Pollutants by Nuwagaba, Emmanuel, Abdulkadir, Taofeeq Sholagberu, Agwe, Michael Tobby, Philip, Tibenderana, Ako, Terseer, Moses N., Twesigye-omwe

“…The parameters tested were Temperature, pH, Electrical Conductivity (EC), Total Dissolved Solids (TDS), Total Coliforms (TC), Faecal Coliforms (FC), Total Suspended Solids (TSS), Biochemical Oxygen Demand (BOD) and Oil & Grease (OG)The results of the study showed that the bio retention model drastically improved storm water quality by reducing values of EC, TDS, TC, FC, TSS, BOD and OG as compared to the tested raw storm water samples. …”
Get full text

Impact of Ecobiol plus ® feed additive on growth performance, physiological response, oxidative status and immunological status of Nile tilapia (Oreochromis niloticus) fingerlings... by Amira A. Omar, Doaa H. Assar, Mustafa Shukry, Aya Abo El-Ezz, Foad A. Farrag, Wesam E. Abd El-Aziz, Eman M. Moustafa

“…The group receiving 0.4 g/kg of Ecobiol plus® exhibited the most significant improvements in growth performance, including higher weight gain, specific growth rate, and feed conversion efficiency (p < 0.05). Blood and biochemical assessments indicated increased hemoglobin, total protein, and globulin levels, reflecting improved physiological and immunological conditions. …”
Get full text

Integrated physiological and transcriptomic analysis uncovers the mechanism of moderate nitrogen application on promoting the growth and (-)-borneol accumulation of Blumea balsamif... by Yuan Yuan, Wei-Jie Tang, Wei-Jie Tang, Jia-Yuan Cao, Ke Zhong, Ke Zhong, Ze-Jun Mo, Ying Zhou, Yu-Xin Pang, Yu-Xin Pang

“…This study aimed to elucidate the effects of N on growth and (-)-borneol synthesis at the molecular level.MethodsA field experiment was conducted in which B. balsamifera plants were fertilized with three different nitrogen regimes: 0 kg N ha-1 (control, CK), 150 kg N ha-1 (N1 treatment), and 300 kg N ha-1 (N2 treatment). Physiological and biochemical assessments were performed to evaluate the growth and metabolic responses of the plants under these varying N conditions. …”
Get full text

Comparison of Robot-Assisted, Laparoscopic, and Open Radical Prostatectomy Outcomes: A Systematic Review and Network Meta-Analysis from KSER Update Series by Do Kyung Kim, Young Joon Moon, Doo Yong Chung, Hae Do Jung, Seung Hyun Jeon, Seok Ho Kang, Sunghyun Paick, Joo Yong Lee

“…<i>Results</i>: A total of 80 studies were finally included in the present study. Biochemical recurrence (BCR) rates were lower for RARP than for ORP (RR 0.713, 95% CrI 0.587–0.869) and LRP (RR 0.672, 95% CrI 0.505–0.895). …”
Get full text

Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans by Bryan J. Neth, Kevin Huynh, Corey Giles, Tingting Wang, Natalie A. Mellett, Thy Duong, Colette Blach, Leyla Schimmel, Thomas C. Register, Kaj Blennow, Henrik Zetterberg, Richa Batra, Annalise Schweickart, Amanda Hazel Dilmore, Cameron Martino, Matthias Arnold, Jan Krumsiek, Xianlin Han, Pieter C. Dorrestein, Rob Knight, Peter J. Meikle, Suzanne Craft, Rima Kaddurah-Daouk

“…Results Here we identified substantial changes in response to MMKD intervention, aside from metabolic changes associated with a ketogenic diet, we identified a a global elevation across all plasmanyl and plasmenyl ether lipid species, with many changes linked to clinical and biochemical markers of AD. We further validated our findings by leveraging our prior clinical studies into lipid related changeswith AD (n = 1912), and found that the lipidomic signature with MMKD was inversely associated with the lipidomic signature of prevalent and incident AD. …”
Get full text

A comparative analysis in monitoring 24-hour urinary copper in wilson disease: sampling on or off treatment? by Isabelle Mohr, Patrick Lamade, Christophe Weber, Viola Leidner, Sebastian Köhrer, Alexander Olkus, Matthias Lang, Andrea Langel, Patrischia Dankert, Melanie Greibich, Silke Wolf, Holger Zimmer, Patrick Michl, Aurélia Poujois, Karl Heinz Weiss, Uta Merle

“…At T0, patients were in the stable maintenance phase, with a median treatment duration of 21.9 years. The levels of the biochemical markers liver and copper metabolism remained stable over the 12-month observation period for all patients. 24 h-UCE off-therapy significantly decreased from T0 to T2 (p = 0.03), whereas no statistically significant differences were detected for 24 h-UCE after therapy. …”
Get full text

Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats by Baocang Yin, Baocang Yin, Mingzhen Yang, Mingzhen Yang, Bowen Wang, Bowen Wang, Yun Zhang, Yun Zhang, Ningli Li, Ningli Li, Qin Li, Yingying Li, Cory J. Xian, Tiejun Li, Tiejun Li, Yuankun Zhai, Yuankun Zhai

“…After 13 weeks of treatment, the rats were sacrificed to measure bone turnover markers, related tissue biochemical indices, microstructure parameters, and osteoclastogenesis promotor RANKL and inhibitor OPG expression levels. …”
Get full text

Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Conclusions: Hematological and biochemical parameters, as well as the antioxidant system, improved following clove oil treatment, leading to a reduction in hepatorenal damage. …”
Get full text

Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota by Polina V. Popova, Artem O. Isakov, Anastasiia N. Rusanova, Stanislav I. Sitkin, Anna D. Anopova, Elena A. Vasukova, Alexandra S. Tkachuk, Irina S. Nemikina, Elizaveta A. Stepanova, Angelina I. Eriskovskaya, Ekaterina A. Stepanova, Evgenii A. Pustozerov, Maria A. Kokina, Elena Y. Vasilieva, Lyudmila B. Vasilyeva, Soha Zgairy, Elad Rubin, Carmel Even, Sondra Turjeman, Tatiana M. Pervunina, Elena N. Grineva, Omry Koren, Evgeny V. Shlyakhto

“…Machine learning models were created using CGM data, meal content, lifestyle factors, biochemical parameters, and microbiota data (16S rRNA gene sequence analysis). …”
Get full text

The effects of Lepidium meyenii on MSG-induced subfertility in male Wistar rats: Targeting oxidative stress, pro-inflammatory cytokines, steroidogenic enzymes, and reproductive hor... by Temidayo S. Omolaoye, Surendra Singh Rawat, Naglaa Gamil Shehab, Eslam El Nebrisi, Stefan S. Du Plessis

“…The testis and prostate were used for biochemical assays and immunofluorescent localization of biomarkers of interest. …”
Get full text

ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells by Lara Hundsdorfer, Marie Muenkel, Raul Aparicio-Yuste, Julio Cesar Sanchez-Rendon, Maria Jose Gomez-Benito, Aylin Balmes, Tilman E. Schäffer, Ana Velic, Yi-Ting Yeh, Iordania Constantinou, Kathryn Wright, Gizem Özbaykal Güler, Dominik Brokatzky, Boris Maček, Serge Mostowy, Effie E. Bastounis

“…However, the underlying biochemical pathways remain elusive. Here, using in vitro (epithelial monolayers) and in vivo (zebrafish larvae) models of infection with L. monocytogenes or Shigella flexneri, we explored the role of extracellular-signal-regulated kinase (ERK) activity waves in coordinating the mechanical battle between infected and surrounder uninfected cells that leads to CICE. …”
Get full text