Personalized medicine: An alternative for cancer treatment by Devendra Singh, Vinay Kumar Dhiman, Minakshi Pandey, Vivek Kumar Dhiman, Avinash Sharma, Himanshu Pandey, Sunil Kumar Verma, Rajeev Pandey

“…Precision medicine, often known as personalized medicine, is a new cancer treatment technique that focuses on tailoring medication to each patient's specific genetic, biochemical, and lifestyle factors. The goal is to optimize tumor response while minimizing therapy side effects, resulting in improved patient care and quality of life. …”
Get full text

The Critical Role of YAP/BMP/ID1 Axis on Simulated Microgravity‐Induced Neural Tube Defects in Human Brain Organoids by Di Guo, Bin Yao, Wen‐Wei Shao, Jia‐Chen Zuo, Zhe‐Han Chang, Jian‐Xin Shi, Nan Hu, Shuang‐Qing Bao, Meng‐Meng Chen, Xiu Fan, Xiao‐Hong Li

“…Abstract Integrated biochemical and biophysical signals regulate embryonic development. …”
Get full text

X-Linked Autism Type 9 Caused by a Hemizygote Pathogenic Variant in the TMLHE Gene: Etiological Diagnosis in an Adult Male with Moderate Intellectual Disability by Verhoeven WM, Pfundt R, Engelke UF, Kluijtmans LA, Egger JI

“…Extensive somatic, neurological, psychiatric, and neuropsychological investigations were performed next to examination of hematological and biochemical parameters including plasma carnitine status. …”
Get full text

Protease shaving of Mycobacterium tuberculosis facilitates vaccine antigen discovery and delivery of novel cargoes to the Mtb surface by Bianca A. Lepe, Christine R. Zheng, Owen K. Leddy, Benjamin L. Allsup, Sydney L. Solomon, Bryan D. Bryson

“…In this study, we established a multiplexed and quantitative biochemical strategy to study the surface of Mycobacterium tuberculosis (Mtb) and identified new vaccine targets. …”
Get full text

Differences in gut microbial diversity and composition between growth phenotypes of farmed juvenile sandfish, Holothuria scabra by Joselito A. Tabardillo, Marie Antonette Juinio-Meñez, Adam M. Reitzel, Rachel Ravago-Gotanco

“…For the sandfish Holothuria scabra, a tropical sea cucumber species, there is a scarcity of information on its intestinal microbiota in relation to host growth, which could provide insights into the processes that affect growth and identify microorganisms with probiotic or biochemical potential that could improve current production strategies. …”
Get full text

Carotenoids and carotenes in the fruits of <i>Cucurbita maxima</i>, <i>C. moschata</i> and <i>C. pepo</i> under the conditions of Northwestern Russia by T. M. Piskunova, T. V. Shelenga, P. V. Ozersky, A. E. Solovyeva

“…The identified Cucurbita accessions with high content of carotenes and carotenoids can be used as valuable source material for breeding cultivars with improved biochemical composition, which can broaden the range of functional food products when grown in the regions with unfavorable conditions for the production of this crop.…”
Get full text

Overcoming barriers for investigating nickel-pincer nucleotide cofactor-related enzymes by Jorge L. Nevarez, Aiko Turmo, Santhosh Gatreddi, Swati Gupta, Jian Hu, Robert P. Hausinger

“…The methods discussed here further our abilities to investigate the unique activities of Lar proteins.IMPORTANCEEnzymes containing the nickel-pincer nucleotide (NPN) cofactor are prevalent in a wide range of microorganisms and catalyze various critical biochemical reactions, yet they remain underexplored due, in part, to limitations in current research methodologies. …”
Get full text

Cultivation of Different Oyster Mushroom (Pleurotus species) on Coffee Waste and Determination of Their Relative Biological Efficiency and Pectinase Enzyme Production, Ethiopia by Guta Dissasa

“…They are known to produce extracellular enzymes, particularly pectinase, which contribute to the biochemical decomposition of pectin-rich lignocellulosic wastes biomass. …”
Get full text

Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model by Wenyue Xue, Yuxin Tian, Yuanping Xiong, Feng Liu, Yanmei Feng, Zhengnong Chen, Dongzhen Yu, Shankai Yin

“…The altered expression of Bhmt results in a dramatic change in multiple biochemical reactions and a disruption of nutrient homeostasis in the endolymph which may contribute to hearing loss of Slc26a4 knockout mouse.…”
Get full text

Synergic Renoprotective Effects of Combined ASC Therapy with RAAS Blockade in Experimental Advanced CKD by Marina P. C. Maires, Krislley R. Pereira, Everidiene K. V. B. Silva, Victor H. R. Souza, Flavio Teles, Paulyana F. Barbosa, Margoth R. Garnica, Felipe M. Ornellas, Irene L. Noronha, Camilla Fanelli

“…Animals were followed until 30 days of CKD, when body weight, systolic blood pressure, biochemical, histological, immunohistochemical, and gene expression analysis were performed. …”
Get full text

Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy by Gang Xi, Christine Wai, David Clemmons

“…It also prevented the increase of retinal vascular permeability (0.92±0.62 vs. 1.63±0.99%/g/h, p<0.001). Biochemical analyses of retinal extracts showed that the anti-IAP antibody inhibited IAP/SHPS-1 association and SHPS-1 phosphorylation. …”
Get full text

GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial by Minh Tam Le, Dac Nguyen Nguyen, Jessica Zolton, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Alan Decherney, Micah J. Hill

“…There was no difference in ovulation rates in either group receiving GnRHa or hCG trigger for ovulation. Biochemical and CPR were higher in patients who received hCG (28.3% and 23.2%) versus GnRHa (14.3% and 13.3%) (p=0.023, OR 0.42, 95%CI=0.21−0.86 and p=0.096, OR 0.51, 95%CI=0.24−1.07, respectively). …”
Get full text

fragSMILES as a chemical string notation for advanced fragment and chirality representation by Fabrizio Mastrolorito, Fulvio Ciriaco, Maria Vittoria Togo, Nicola Gambacorta, Daniela Trisciuzzi, Cosimo Damiano Altomare, Nicola Amoroso, Francesca Grisoni, Orazio Nicolotti

“…When compared with SMILES, SELFIES and t-SMILES for de novo design, the fragSMILES notation showed its promise in generating molecules with desirable biochemical and scaffolds properties.…”
Get full text

Insulin Resistance Markers to Detect Nonalcoholic Fatty Liver Disease in a Male Hispanic Population by Maritza Pérez-Mayorga, Jose P. Lopez-Lopez, Maria A. Chacon-Manosalva, Maria G Castillo, Johanna Otero, Daniel Martinez-Bello, Diego Gomez-Arbelaez, Daniel D. Cohen, Patricio Lopez-Jaramillo

“…Anthropometric measurements and biochemical determinations (glycemia, lipid profile, and insulin) were obtained, and ultrasound studies were performed to evaluate the presence of NAFLD. …”
Get full text

Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study by Jie Yang, Wenna Wang, Yizhen Lu, Chunyao Li, Shuwu Wei, Weiwei Sun

“…Methods Retrospectively analyzed the clinical and biochemical characteristics of 224 patients with PNs and 488 patients with non-PNs in patients with T2DM, and compared the clinical data of 72 patients with large nodules (≥ 5 mm) and 152 patients with small nodules (< 5 mm) in the pulmonary nodules (PNs) group. …”
Get full text

Variation in Clinical Presentation, Metabolic Profile, Hormonal Parameters and Inflammatory Markers in Polycystic Ovary Syndrome Women with and without Polycystic Ovary Morphology... by Sweekruti Jena, Ipsita Mishra, Anoj Kumar Baliarsinha, Debarchan Jena, Madhumita Debata

“…All participants underwent a detailed clinical evaluation and biochemical investigations, including high-sensitivity C-reactive protein, serum adiponectin, luteinising hormone, follicle-stimulating hormone, total testosterone and serum anti-Mullerian hormone. …”
Get full text

Genetic diversity of kaffir sorghum accessions from the VIR collection in kafirin-encoding loci by N. V. Alpatieva, I. N. Anisimova, M. K. Ryazanova, V. V. Vasipov, R. A. Abdullaev, O. I. Romanova, E. E. Radchenko

“…Sorghum grain has a valuable biochemical composition and is utilized in both food and feed production. …”
Get full text

Induced resistance to the greenbug aphid Schizaphis graminum Rond. in species of the genus Triticum by S. D. Rumyantsev, S. V. Veselova, G. F. Burkhanova, I. V. Maksimov

“….– infested with S. graminum greenbugs by physiological, biochemical, and molecular methods. Analysis of antibiosis and endurance showed that T. timopheevii k-58666 and T. monococcum k-39471 were resistant to S. graminum, the latter accession being the most enduring. …”
Get full text

Antioxidant and anti–inflammatory effects of Helichrysum plicatum DC. subsp. plicatum extract in an experimental model of acute urolithiasis by Selvinaz Yakan, Kıvılcım Eren Erdoğan, Yusuf Kenan Dağlıoğlu, Tuba Aydın, Ahmet Çakır

“…Furthermore, the measured biochemical measurements supported the anti–urolithiasis effects of HP. …”
Get full text

Intestinal Microbiota in Patients with Chronic Heart Failure and Systolic Dysfunction by M. V. Fadeeva, A. V. Kudryavtseva, G. S. Krasnov, M. R. Skhirtladze, V. T. Ivashkin

“…However, a correlation was revealed between the relative number of certain bacterial families and the severity of impaired contractile function, the level of the inflammatory marker and the biochemical marker of heart failure.Conclusions. The obtained data indicate differences in the intestinal microbiota composition in patients with and without heart failure. …”
Get full text