Effects of GABA Supplementation on Intestinal SIgA Secretion and Gut Microbiota in the Healthy and ETEC-Infected Weanling Piglets by Yuanyuan Zhao, Jing Wang, Hao Wang, Yonggang Huang, Ming Qi, Simeng Liao, Peng Bin, Yulong Yin

“…The growth performance, organ indices, amino acid levels, and biochemical parameters of serum, intestinal SIgA concentration, gut microbiota composition, and intestinal metabolites were analyzed at the end of each stage. …”
Get full text

Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

Get full text

Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes by Aldo Ferreira-Hermosillo, Mario Molina-Ayala, Claudia Ramírez-Rentería, Guadalupe Vargas, Baldomero Gonzalez, Armando Isibasi, Irma Archundia-Riveros, Victoria Mendoza

“…Patients were considered to have metabolic syndrome when they fulfilled the joint statement criteria and were evaluated for clinical, biochemical, and immunological features. Methods. We determined serum IL-6, IL-8, IL-10, and TNF with flow cytometry and adiponectin and resistin concentrations with enzyme linked immunosorbent assay in patients with and without metabolic syndrome. …”
Get full text

Bone and Mineral Metabolism in Patients with Primary Aldosteronism by Luigi Petramala, Laura Zinnamosca, Amina Settevendemmie, Cristiano Marinelli, Matteo Nardi, Antonio Concistrè, Francesco Corpaci, Gianfranco Tonnarini, Giorgio De Toma, Claudio Letizia

“…In 73 PA patients we evaluated anthropometric and biochemical parameters, renin-angiotensin-aldosterone system, calcium-phosphorus metabolism, and bone mineral density; control groups were 73 essential hypertension (EH) subjects and 40 healthy subjects. …”
Get full text

Structural and functional features of phytoene synthase isoforms PSY1 and PSY2 in pepper Capsicum annuum L. cultivars by E. A. Dyachenko, M. A. Filyushin, G. I. Efremov, E. A. Dzhos, A. V. Shchennikova, E. Z. Kochieva

“…Transit peptides were more variable, and their similarity in the PSY1 and PSY2 proteins did not exceed 78.68 %. According to the biochemical data obtained, the largest amounts of chlorophylls and carotenoids across the cultivars studied were detected in immature and ripe fruits of the cv. …”
Get full text

Structural variability of sunflower gene for methionine-rich albumin SFA8 by I. N. Anisimova, N. V. Alpatieva, S. V. Goryunova, D. V. Goryunov, Al. V. Konarev, V. A. Gavrilova, E. E. Radchenko

“…The data on the SFA8 gene sequence polymorphism are important understanding the molecular mechanisms of genotypic differences in biochemical and functional properties of the protein, and he revealed differences in the intron secondary structure can be important for understanding expression patterns of the protein.…”
Get full text

EGCG improve meat quality, restore lipid metabolism disorder and regulate intestinal flora in high-fat fed broilers by Lujia Gao, Chen Liu, Jiaqi Wu, Ying Cui, Man Zhang, Chongpeng Bi, Anshan Shan, Xiujing Dou

“…The results showed that EGCG increased lightness (L*) 24 h (P < 0.05), and decreased drip loss (P < 0.05) of chicken meat; Enhanced the presence of non-essential and flavor amino acids in muscle tissue and greatly enhanced the antioxidant capacity of broilers, leading to a noteworthy upregulation of antioxidant genes at the genetic level (P < 0.05); Reduced in blood lipids, blood glucose, liver and abdominal fat accumulation in high-fat diet-induced obese chickens (P < 0.05), markedly improved serum and liver biochemical parameters, and histological analysis results also demonstrated that EGCG markedly decreased hepatic lipid accumulation caused by HFD feeding. …”
Get full text

The viability of treated piggery wastewater for reuse in agricultural irrigation by Viviane F Velho, Rodrigo A Mohedano, Paulo Belli Filho, Rejane HR Costa

“…The performance of the reservoirs improved continuously during the cold seasons, with the removal efficiencies of total biochemical oxygen demand (BOD5), total Kjeldahl nitrogen (TKN), and Escherichia coli reaching 52%, 64%, and 99.9%, respectively, with an effluent concentration of 144 mg·Lâ1 for BOD5 and 256 mg·Lâ1 for TKN. …”
Get full text

Protein identification using Cryo-EM and artificial intelligence guides improved sample purification by Kenneth D. Carr, Dane Evan D. Zambrano, Connor Weidle, Alex Goodson, Helen E. Eisenach, Harley Pyles, Alexis Courbet, Neil P. King, Andrew J. Borst

“…This identification was validated through comparisons with DLST structures in the Protein Data Bank, AlphaFold 3 predictions based on the DLST sequence from our E. coli expression vector, and traditional biochemical methods. The identification informed subsequent modifications to our purification protocol, which successfully excluded DLST from future preparations. …”
Get full text

Association between blood test indicators and atrial fibrillation in elderly patients aged 65 and above in the Central Jiangsu region: a cross-sectional study by Hao Liang, Shuai Zhang, Ye Zhu

“…Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to select important variables from routine blood tests and biochemical indicators and their derived indicators (such as TyG, TyG-BMI, TG/HDL-c, RAR, NLR, MHR). …”
Get full text

Lymphadenopathies: A Retrospective Study of Epidemiology, Characteristics, Diagnosis and Treatment Outcomes of Patients in a Tertiary Hospital in Mogadishu-Somalia by Kıratlı K, Bulut M, Ali MA, Aysin M, Ali AM, Mohamed Hirsi I, Bashir AM

“…The purpose of this research was to identify the clinical and diagnostic characteristics of Somalian patients suffering from swollen lymph nodes.Methods: Under the purview of this study, the diagnoses, patient clinical courses, and treatment outcomes were ascertained retrospectively by analyzing the biochemical, microbiological, radiological, and pathological data of the cases in all age groups who underwent therapy for lymphadenitis at Mogadishu Somali Turkey Recep Tayyip Erdo&gbreve;an Training and Research Hospital between January 2016 and September 2023.Results: During the study period, 317 patients were followed up, with 53.3% of the patients as female, 46.7% as male, 28.1% as pediatric, 63.1% as adult, and 8.8% were elderly patients. …”
Get full text

Optimizing Flammulina velutipes residue use: impact on health metrics and performance in three-yellow chickens by Yuanxiao Li, Yuanxiao Li, Dan Liu, Wang Li, Wang Li, Longmei Zhao, Pinghua Cao, Yanbo Ma, Yanbo Ma, Ke Ding, Cai Zhang, Cai Zhang, Ning Liu

“…Blood samples were collected from the jugular vein on days 28 and 48 to determine serum biochemical indices. Caecum contents were collected on day 48 to assess flora diversity.Results and discussionNo significant differences were observed in dry matter intake (DMI), average daily gain (ADG), or feed conversion ratio (FCR) between the 2% and 4% group and the CON. …”
Get full text

The association between age at menarche (AAM) and cardiovascular disease (CVD) risk factors in the MASHAD cohort study by Niloofar Shabani, Sara Saffar Soflaei, Khadijeh Bavafa-Valenlia, Nayereh Esmaeilzadeh, Maryam Mohammadi-Bajgriran, Zahra Namazibaygi, Mohsen Moohebati, Gordon A. Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan

“…Baseline demographic, anthropometric data, and biochemical profiles were also collected. The levels of depression and anxiety were evaluated using a validated Persian version of the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). …”
Get full text

FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy by Na Zhang, Yang Meng, Song Mao, Huiling Ni, Canhua Huang, Licong Shen, Kun Fu, Lu Lv, Chunhong Yu, Piyanat Meekrathok, Chunmei Kuang, Fang Chen, Yu Zhang, Kai Yuan

“…Increasing O-GlcNAcylation in patient-derived endometrial epithelial organoids promotes proliferation and stem-like cell properties, whereas decreasing O-GlcNAcylation limits the growth of endometrial cancer organoids. CRISPR screen and biochemical characterization reveal that tumor suppressor F-box only protein 31 (FBXO31) regulates O-GlcNAcylation homeostasis in EC by ubiquitinating the O-GlcNAc transferase OGT. …”
Get full text

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…Kidney injury was evaluated by HE staining and biochemical markers, including serum creatinine (Cr), blood urea nitrogen (BUN), urinary protein, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), and retinol binding protein (RBP). …”
Get full text

Lipid-encapsulated gold nanoparticles: an advanced strategy for attenuating the inflammatory response in SARS-CoV-2 infection by Sanjeevram Dhandapani, Yujeong Ha, Rongbo Wang, Tae Woo Kwon, Ik-Hyun Cho, Yeon-Ju Kim

“…This effect was mitigated with KGS-NE oral administration, as observed through H&E and qRT-PCR analysis. Biochemical analysis at various oral administration concentrations demonstrated that KGS-NE had no adverse effects on the kidney and liver. …”
Get full text

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japane... by Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh

“…In this human clinical study, we aimed to investigate the safety and effects of 8-week oral administration of NMN on biochemical, metabolic, ophthalmologic, and sleep quality parameters as well as on chronological alterations in NAD+ content in peripheral tissues. …”
Get full text

Salmonella Serovars, Antibiotic Resistance, and Virulence Factors Isolated from Intestinal Content of Slaughtered Chickens and Ready-to-Eat Chicken Gizzards in the Ilorin Metropoli... by M. A. Raji, H. M. Kazeem, K. A. Magyigbe, A. O. Ahmed, D. N. Lawal, I. A. Raufu

“…Salmonellae were isolated and identified according to the techniques recommended by the World Health Organization: preenrichment, selective plating, biochemical testing, and serotyping. A total number of forty-three (43) Salmonella isolates consisting of 33 from intestinal contents and 10 from ready-to-eat chicken gizzards were isolated and identified. …”
Get full text

Serum ZAG Levels Were Associated with eGFR Mild Decrease in T2DM Patients with Diabetic Nephropathy by Lingling Xu, Weihong Yu, Meng Niu, Caixia Zheng, Bin Qu, Yan Li, Jing Wang, Ping Huang, O. Wang, Fengying Gong

“…A total of 438 T2DM patients (61.3 ± 4.0 y) were recruited and the demographic, anthropometric, and biochemical parameters were all collected. Serum ZAG levels were determined by commercially available ELISA kits. …”
Get full text

Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model by Blanca Martínez Soriano, Antonio Güemes, Guillermo Pola, Azucena Gonzalo, Pilar Palacios Gasós, Ana C. Navarro, Roberto Martínez-Beamonte, Jesús Osada, José J. García

“…The effect of melatonin on fat metabolism can be summarized as a decrease in lipid peroxidation and a decrease in oxidative stress, biochemical phenomena intimately related to fat deposition in the hepatocyte. …”
Get full text