Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography by Che-Ning Yang, Chia-Ping Chen, Yi-Ting Hsieh

“…Methods A total of 24 PAN patients who had been for 3 years or more and underwent SD-OCT were recruited from the UK Biobank, with exclusions for diabetes, eye disease, or abnormal CFP findings. …”
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Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring by Yixue Wang, Hongru Sun, Gen Li, Jingxue Xu, Siyu Wang, Shijie Zhang, Tianle Zhou, Tianshu Han, Changhao Sun, Jianqun Ma, Xiaoyuan Wang, Hang Yin

“…Abstract Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life factors in its incidence and mortality is unclear. Using UK Biobank data, we explore the association among breastfeeding, maternal smoking, smoking in offspring, and oesophageal cancer risk in adult offspring via multivariable Cox regression. …”
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Enriched phenotypes in rare variant carriers suggest pathogenic mechanisms in rare disease patients by Lane Fitzsimmons, Undiagnosed Diseases Network, Brett Beaulieu-Jones, Shilpa Nadimpalli Kobren

“…Methods In this pilot study, we present an approach to understand the underlying pathways leading to seizures in patients from the Undiagnosed Diseases Network (UDN) by analyzing aggregated genotype and phenotype data from the UK Biobank (UKB). Specifically, we look for enriched phenotypes across UKB participants who harbor rare variants in the same gene known or suspected to be causally implicated in a UDN patient’s recessively manifesting disorder. …”
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Association of life’s essential 8 and inflammatory biomarkers with nutritional anemia in UK adults by Jingjing Wang, Xueting Qi, Guozheng Wang, Weijing Wang, Dongfeng Zhang

“…This prospective cohort study included 181,069 participants from UK Biobank. CVH was categorized into low (0–49), medium (50–79), and high (80–100) based on the LE8 score. …”
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Creatine and pregnancy outcomes, a prospective cohort study in low-risk pregnant women: study protocol by Deborah L De Guingand, Stacey J Ellery, Miranda L Davies-Tuck, Hayley Dickinson

“…Cord blood and placenta (including membranes and cord) are collected at birth. A biobank of tissue samples for future research is being established. …”
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Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities by Pei Pei Lau, Chun-Yu Wei, Min-Rou Lin, Wan-Hsuan Chou, Yu-Jui Yvonne Wan, Wei-Chiao Chang

“…Results In this study, a total of 145,356 Taiwan Biobank participants were included in the discovery analysis. …”
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Genetic proxies for clinical traits are associated with increased risk of severe COVID-19 by N. J. M. Chaddock, S. S. R. Crossfield, M. Pujades-Rodriguez, M. M. Iles, A. W. Morgan

“…PRS were optimized for 23 clinical variables and related traits previously-associated with severe COVID-19 in up to 450,449 UK Biobank participants, and tested in 9,560 individuals diagnosed in the pre-vaccination era. …”
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Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics by Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon

“…We provide a genomic resource from a phenome-wide application of our models to more than 1,500 phenotypes from the UK Biobank. Using longitudinal, genetically determined expression, we implement a predictive causality framework, evaluating the prediction of future values of a target gene expression using prior values of a putative regulatory gene. …”
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The brain structure underlying the nonlinear association between early-life tobacco smoke exposure and the risk for cognitive decline and dementia in adulthood: a large prospective... by Changfu Lin, Fabin Lin, Kaitai Yang, Yuxuan Zhong, Yan Luo, Hanchen Chen, Wenjing Zhang, Xuanjie Chen, Qinyong Ye, Yuqi Zeng, Guoen Cai

“…Methods We used data from the UK Biobank (UKB) to assess early-life tobacco exposure, including in utero exposure and the age at which smoking was initiated. …”
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Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics by Ruijie Xie, Teresa Seum, Sha Sha, Kira Trares, Bernd Holleczek, Hermann Brenner, Ben Schöttker

“…Methods Data from 10,257 to 1,039 patients with type 2 diabetes from the UK Biobank (UKB) and the German ESTHER cohort, respectively, were used for model derivation, internal and external validation. …”
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Preserved ratio impaired spirometry, airflow obstruction, and their trajectories in relationship to chronic kidney disease: a prospective cohort study by Ikramulhaq Patel, JingYan Zhang, YinHe Chai, YuShun Qiao, HongJian Gong, Hui Xu, JianBo Zhou

“…This study aimed to investigate the impact of baseline and trajectories of spirometry findings on future chronic kidney disease (CKD) events. This UK Biobank cohort study included participants with CKD who underwent spirometry at baseline (2006–2010). …”
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Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk by Zeyu Wang, Zixiao Yin, Guangyong Sun, Dong Zhang, Jianguo Zhang

“…The research incorporated UK Biobank genomic data to examine associations between genetic variants and lipid metabolism parameters. …”
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Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy by Baoyi Feng, Chenxi Jin, Zhenzhe Cheng, Xingle Zhao, Zhuoer Sun, Xiaofei Zheng, Xiang Li, Tingting Dong, Yong Tao, Hao Wu

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Physical activities and breast cancer: a Mendelian randomization study by Lishan Ding, Qingliang Chen, Hao Liang, Meng Shen, Ming Zheng, Zhaojun Li

“…Material and methods Genome-wide association studies utilizing data from the UK Biobank baseline were employed to analyze PA phenotypes, encompassing 460,376 participants. …”
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Identifying MTHFD1 and LGALS4 as Potential Therapeutic Targets in Prostate Cancer Through Multi-Omics Mendelian Randomization Analysis by Huan Han, Hanwen Su, Zhihua Lv, Chengliang Zhu, Jingtao Huang

“…<b>Methods:</b> We integrated eQTL data from the eQTLGen Consortium and pQTL data from UK Biobank Proteome Plasma Proteins (UKB-PPP) and deCODE health datasets. …”
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Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis by Cheng Z, Wu J, Xu C, Yan X

“…The primary analytic approach was inverse variance weighted (IVW).Results: LDSC analysis revealed moderate genetic correlations between frailty and Global Biobank Meta-Analysis Initiative (GBMI) COPD (rg = 0.643, P = 6.66× 10− 62) as well as FinnGen COPD (rg = 0.457, P = 8.20× 10− 28). …”
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Association of active commuting with incidence of depression and anxiety: prospective cohort study by Jingwen Fan, Xuesong Zhang, Xiaocan Jia, Zhixing Fan, Chaojun Yang, Yuping Wang, Chenyu Zhao, Nana Wang, Xuezhong Shi, Yongli Yang

“…This study included 240,547 workers in the UK Biobank. The exposure variable was the mode of transport used to get to and from work including active (walking, cycling, mixed mode) and non-active commuting (car or public transport). …”
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Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis by Renjie Gu, Liangqiong Chen, Minhui Hua, Huangtai Miao, Yongwei Qin

“…Instrumental variables were selected from the IEU platform, comprising 129,080 GERD cases and 473,524 controls from the UK Biobank. TMD data from the FinnGen project included 6,314 cases and 222,498 controls. …”
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Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility by Shinya Nakada, Joey Ward, Rona J. Strawbridge, Paul Welsh, Carlos Celis-Morales, Frederick K. Ho, Jill P. Pell

“…Methods This is a prospective cohort study using UK Biobank. Diagnoses of anxiety disorder and depression were ascertained through linked hospital admission data. …”
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Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study by Xunliang Li, Wenman Zhao, Haifeng Pan, Deguang Wang

“…Genetic associations with early-life and adult body size were obtained from a genome-wide association study of 453,169 participants in the U.K. Biobank, and genetic associations with CKD were obtained from the CKDGen and FinnGen consortia. …”
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