Integrative Taxonomy, Phylogeny, and New Species of the Weevil Genus Onyxacalles Stüben (Coleoptera: Curculionidae: Cryptorhynchinae) by Peter E. Stüben, Jonas J. Astrin

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Protocol for perfusing human axillary lymph nodes ex vivo to study structure and function in real time by Amy Llewellyn, Rachel Barrow-McGee, Julia Stevenson, Jasmine Gore, Kalnisha Naidoo

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Protocol for Immune Cell Isolation, Organoid Generation, and Co-culture Establishment from Cryopreserved Whole Human Intestine by Enrique Gamero-Estevez, Inga Hensel, Michelle Steinhauer, Olivia Müllertz, Elizaveta Savochkina, Ibrahim Sektioglu, Bilgenaz Stoll, Shaghayegh Derakhshani, Sarah Devriese, Kyungbo Kim, Martin Resnik-Docampo

“…We describe how to generate a biobank that can be used to isolate specific immune cell subtypes, generate organoid lines, and establish autologous immune cell-organoid co-cultures.…”
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CFTR Expression Analysis for Subtyping of Human Pancreatic Cancer Organoids by Alexander Hennig, Laura Wolf, Beatrix Jahnke, Heike Polster, Therese Seidlitz, Kristin Werner, Daniela E. Aust, Jochen Hampe, Marius Distler, Jürgen Weitz, Daniel E. Stange, Thilo Welsch

“…Methods. A PDAC organoid biobank was generated from human primary tumor samples containing 22 lines. …”
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Low-grade systemic inflammation, but not neuroinflammation, is associated with 12-month postoperative outcome after total hip arthroplasty in patients with painful osteoarthritis:... by Morten R. Blichfeldt-Eckhardt, Claus Varnum, Jørgen T. Lauridsen, Lasse E. Rasmussen, Winnie C. P. Mortensen, Hanne I. Jensen, Henrik B. Vaegter, Kate L. Lambertsen

“…Methods: A total of 50 patients from the Danish Pain Research Biobank (DANPAIN-Biobank) between January and June 2018 were included. …”
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Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and me... by Maciej Banach, Martyna Fronczek, Tadeusz Osadnik, Agnieszka Gach, Dominik Strapagiel, Marcin Słomka, Mateusz Lejawa, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Gregory Y.H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Jacek Jóźwiak

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Investigating mobile element variations by statistical genetics by Shohei Kojima

“…We recently developed a variant caller that can accurately identify and genotype MEVs from biobank-scale short-read whole-genome sequencing (WGS) datasets and integrate them into statistical genetics. …”
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Association between air pollution and lifestyle with the risk of developing mild cognitive impairment and dementia in individuals with cardiometabolic diseases by Bo Wang, Lingling Yang, Ting Ma, Shulan He, Jiangping Li, Xian Sun

“…The Cox proportional hazards model was used to evaluate the influence of lifestyle and ambient air pollution on the dementia risk of the CMDs population among 438,681 participants in the UK Biobank. It is found that the risk of developing mild cognitive impairment and dementia in the population seems to increase with the increase in the number of CMDs. …”
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The Cognitive Footprint of Medication Use by Marta Suárez Pinilla, Charlotte R. Stoner, Martin Knapp, Parashkev Nachev, Martin Rossor

“…Results We replicate positive and negative cognitive effects of commonly used medications in UK Biobank, and extend observed associations to two additional cohorts, the EPIC Norfolk, and the Caerphilly Prospective Cohort. …”
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Rat Sarcoma Virus Family Genes in Acute Myeloid Leukemia: Pathogenetic and Clinical Implications by Shaimaa Khattab, Adriatik Berisha, Natalia Baran, Pier Paolo Piccaluga

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Identification of CDKN3 overexpression as a marker of poor prognosis and potential therapeutic target in low-grade glioma by Hongbing Cheng, Xiao Meng, Yanhua Zhang, Pu Wang, Yucheng Lu

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Immune Checkpoint Blockade in Melanoma – Earlier is Better? by Vincas Urbonas, Audrius Dulskas, Edita Baltruškevičienė, Daiva Dabkevičienė

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The association between type 2 diabetes and asthma incidence: a longitudinal analysis considering genetic susceptibility by Fei Chen, Ying Yang, Liping Yu, Lulu Song, Cong Zhang, Yifan He, Lili Wu, Wanlu Ma, Bo Zhang

“…Methods This study utilized data from the UK Biobank longitudinal cohort, involving 388,775 participants. …”
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Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study by Wen-Hao Hu, Jia-An Sun, Chang Liu

“…Methods Exposure data, encompassing various dietary habits such as the consumption of dried and fresh fruits, both cooked and raw vegetables, types of fish (oily and nonoily), and beverages such as tea and coffee, as well as different meats (poultry, beef, pork, and processed), were obtained from the UK Biobank. Conversely, outcome data were derived from the FinnGen study. …”
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The beneficial effects of thymoquinone on viability and differentiation of human adipose tissue-derived mesenchymal stem cells by Ahsen Erginsoy, Nur Seda Gokdemir, Venhar Cinar, Eda Koseoglu, Zeynep Burcin Gonen, Tuba Dilay Kokenek Unal

“…MSCs were obtained from the biobank and treated with concentrations of 50 nM, 100 nM, 200 nM, and 300 nM thymoquinone. …”
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Identification and analysis of individuals who deviate from their genetically-predicted phenotype. by Gareth Hawkes, Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N Beaumont, GIANT Consortium, Jessica Tyrrell, Michael N Weedon, Joel Hirschhorn, Timothy M Frayling, Andrew R Wood

“…Using genome-wide imputed genetic data, we aimed to classify 158,951 unrelated individuals from the UK Biobank as either concordant or deviating from two well-measured phenotypes. …”
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Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits by Jeffrey Okamoto, Xianyong Yin, Brady Ryan, Joshua Chiou, Francesca Luca, Roger Pique-Regi, Hae Kyung Im, Jean Morrison, Charles Burant, Eric B. Fauman, Markku Laakso, Michael Boehnke, Xiaoquan Wen

“…We apply Multi-INTACT to GWAS on 1408 metabolites, integrating the GTEx expression and UK Biobank protein QTL datasets. Multi-INTACT infers 52 to 109% more metabolite causal genes than protein-alone or expression-alone analyses and indicates both gene products are relevant for most gene nominations.…”
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Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients by Othman Abdul-Malak, Yoram Vodovotz, Akram Zaaqoq, Jesse Guardado, Khalid Almahmoud, Jinling Yin, Brian Zuckerbraun, Andrew B. Peitzman, Jason Sperry, Timothy R. Billiar, Rami A. Namas

“…We hypothesized that elevated base deficit (BD) ≥ 4 mEq/L upon admission could be associated with an altered inflammatory response, which in turn may impact differential clinical trajectories. Using clinical and biobank data from 472 blunt trauma survivors, 154 patients were identified after excluding patients who received prehospital IV fluids or had alcohol intoxication. …”
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Schwann cells in regeneration and cancer by Lan Zhang, Jiale Xie, Wenyu Dai, Bing Lu, Sheng Yi

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Causal relationship between educational attainment and the occurrence of venous thromboembolism by Sitong Guo, Sitao Tan, Shiran Qin, Dandan Xu, Henghai Su, Xiaoyu Chen

“…Results Genetically predicted decreased EA was associated with a decreased risk of VTE in both the FinnGen consortium and UK Biobank (FinnGen-VTE: OR = 0.848; 95% CI 0.776—0.927; P = 2.84 × 10–4; UKB-VTE OR = 0.996; 95% CI 0.994—0.999; P = 0.008) under a multiplicative random-effects IVW model. …”
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