Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis by Wenhui Qian, Bei Zhang, Ming Gao, Yuting Wang, Jiachen Shen, Dongbing Liang, Chao Wang, Wei Wei, Xing Pan, Qiuying Yan, Dongdong Sun, Dong Zhu, Haibo Cheng

“…Inspired by the supramolecular self-assembly strategy and natural drug compatibility theory, we successfully obtained berberine (BBR)-chlorogenic acid (CGA) supramolecular (BCS), which is an herbal pair from HLWMD. …”
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PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors by Lan Zou, Rujing Wang, Mengnan Zhao, Yuke Li, Chen Sun, Jinjin Xie, Yan Chen, Qian Jing, Dandan Mi, Sanjun Shi

“…In this study, we took a deliberate approach devoid of any chemical alterations to develop a novel photosensitizer called “pharmaceutical-dots (pharm-dots)” by combining nonemissive polymers (Poly (lactic-co-glycolic acid), PLGA) with nonfluorescent invisible molecules like curcumin, berberine, oridonin into PLGA nanoparticles (PLGA-NPs). …”
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Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats by Houli Li, Benjie Wang, Guiyan Yuan, Xiaoyan Liu, Jing Huang, Lilong Xiong, Di Zhang, Weiyi Feng, Ruichen Guo

“…Three active constituents of BSPs, including paeoniflorin (PF), berberine hydrochloride (BBR), and schizandrin (SCH), were simultaneously determined by the established LC-MS method with electrospray ionization (ESI) in positive selected ion monitoring (SIM) mode at m/z 503.1, 336.0, and 455.2. …”
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Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking by LIU Huiling, TAN Dingying, HUANG Min, CHEN Pingping, ZHANG Wang

“…In terms of cell components (CC), it involved the composition of enzyme regulated complex, cystic cavity, membrane microregion and membrane region. ③ Components-target-pathway network analysis showed that, the main potential active ingredients of <italic>Coptis chinensis</italic> in the treatment of type 2 diabetes mellitus were quercetin, berberine, etc. It can act on mitogen-activated proteinase 1 (MAPK1), serine/threonine protein kinase (AKT1), tumor protein p53 (TP53), transcription factor AP-1 (JUN), tumor necrosis factor (TNF), interleukin-6 (IL-6), which can regulate MAPK, AGEs-RAGE, PI3K-Akt, Toll-like receptors, HIF-1, TNF signaling pathways, etc. ④ The molecular docking results showed that, the molecular docking affinity between the active ingredients of <italic>Coptis chinensis</italic> and the above core targets was less than -7.0 kcal/mol (1 kca/mol=4.186 kJ/mol), and the binding activity was better.Conclusion<italic>Coptis chinensis</italic> may play an important role in the treatment of type 2 diabetes mellitus and its complications by regulating glucose and lipid metabolism, inflammatory response, cell proliferation and apoptosis and promoting oxidative stress, etc.…”
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Exploring the Mechanism of Canmei Formula in Preventing and Treating Recurrence of Colorectal Adenoma Based on Data Mining and Algorithm Prediction by Xiaoling Fu, Yimin Xu, Xinyue Han, Xiangying Lin, Jingnan Wang, Guanhong Li, Xiaochen Fu, Min Zhang

“…After randomization, the patients were divided into a treatment group (receiving CMF granules) or a control group (receiving berberine hydrochloride tablets). The one-year recurrence rate of CRA was used as the key efficacy indicator to assess the effectiveness of CMF in preventing and treating CRA. …”
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Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies by Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Fazle Rabbani, Meherullah Tareen, Roohi Nigar, Amjad Khan, Nicola Zerbinati, Maria L. Tanda, Massimiliano Cazzaniga, Alexander Bertuccioli, Alexander Bertuccioli, Paolo Falasca, Gabriele Damiani, Nicola Villanova

“…Cohort 2 included 22 mildly hyperuricemic adults with metabolic disorders receiving QP, while Cohort 3 comprised 64 obese adults with hypercholesterolemia, further divided into moderately hyperuricemic QP-treated group (n = 20), a moderately hyperuricemic Berberine Phytosome™ and monacolins (BM)-treated group (n = 22), and a normouricemic BM-treated group (n = 22). …”
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Docking to Explicate Interface between Plant-Originated Inhibitors and E6 Oncogenic Protein of Highly Threatening Human Papillomavirus 18 by Satish Kumar, Lingaraja Jena, Maheswata Sahoo, Mrunmayi Kakde, Sangeeta Daf, Ashok K. Varma

“…Traditionally, different natural compounds such as withaferin A, artemisinin, ursolic acid, ferulic acid, (-)-epigallocatechin-3-gallate, berberin, resveratrol, jaceosidin, curcumin, gingerol, indol-3-carbinol, and silymarin have been used as hopeful source of cancer treatment. …”
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