CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Then, we generated and characterized an APP/PS1 mouse model with neuron-specific Cd2ap deletion, using immunoblotting, immunofluorescence, enzyme-linked immunosorbent assay, electrophysiology and behavioral tests. Additionally, we established a stable CD2AP-knockdown SH-SY5Y cell line to further elucidate the specific molecular mechanisms by which CD2AP contributes to AD pathogenesis. …”
Get full text

A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study by Joey El Khoury, Jessica Andraos, Anthony Kanbar, Rami Halabi, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Rodrigue Saad, Antoine Kassis, Maher Abdessater, Raghid El Khoury

“…Data collection consisted of sociodemographic, behavioral, and past medical and familial history characteristics. …”
Get full text

Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…The anxiolytic activity of SM was demonstrated by improved behavior of the animals in the elevated plus maze test and increased SOD activity in the brain. …”
Get full text

Influence of Ni, Al, W doping on microstructure, corrosion and wear resistance of HVOF spraying Fe-based amorphous alloy coatings by Chengwu Zhang, Lei Xie, Qiang Li, Guan Zhang, Chuntao Chang, Hongxiang Li, Xu Ma, Lin Liu

“…The effect of Ni, Al, and W on microstructure, thermal behavior, corrosion resistance, and wear resistance of these fabricated Fe-based AACs were investigated systematically compared to 316L stainless steel (316L SS) substrates. …”
Get full text

Neighborhood environment associations with cognitive function and structural brain measures in older African Americans by Dima L. Chaar, Le Tu, Kari Moore, Jiacong Du, Lauren A Opsasnick, Scott M Ratliff, Thomas H Mosley, Sharon L. R. Kardia, Wei Zhao, Xiang Zhou, Ana V Diez Roux, Fazlay S Faruque, Kenneth R Butler, Jennifer A Smith

“…Further examination of the potential pathways between the neighborhood environment and cognitive function/WMH may allow the development of potential behavioral, infrastructural, and pharmaceutical interventions to facilitate aging in place and healthy brain aging in older adults, especially in marginal populations that are most at risk.…”
Get full text

Deep-learning-based canopy height model generation from sub-meter resolution panchromatic satellite imagery by Charles J Abolt, Javier E Santos, Adam L Atchley, Lucas Wells, Daithi Martin, Russell A Parsons, Rodman R Linn

“…We find minimal differences in fire behavior relative to a baseline case in which only statistical distributions of tree height and crown area are known. …”
Get full text

Percutaneous ultrasound-guided radiofrequency ablation for patients with liver metastases from gastrointestinal stromal tumors by Li Liu, Bing Wang, Zhong-Yi Zhang, Song Wang, Hao Wu, Hong Wang, Wei Wu, Kun Yan, Wei Yang

“…Both univariate and multivariate analysis indicated that extrahepatic metastasis before RFA (p = 0.044) was a significant prognostic factor for OS.Conclusions Liver metastases from GIST exhibit relatively mild biological behavior. RFA is safe and effective, particularly in patients without pre-RFA extrahepatic metastases. …”
Get full text

Co-Optimization of Power Delivery Network Design for 3-D Heterogeneous Integration of RRAM-Based Compute In-Memory Accelerators by Madison Manley, James Read, Ankit Kaul, Shimeng Yu, Muhannad Bakir

“…We quantify steady-state IR-drop impacts in 3D-HI CIM architectures using a framework that combines PDN modeling, 3D-HI power, performance, area estimation, and behavioral modeling. We demonstrate that a drop in supply voltage to CIM arrays increases sensitivity to process, voltage, and temperature (PVT) noise. …”
Get full text

Determinants of handwashing practice and its associated factors among mothers of under-5 children in Kolladiba town, Northwest Ethiopia: cross-sectional study by Getayeneh Antehunegn Tesema, Maereg Wolde, Meshehsa Abate, Gebremeskel Mandefro, Ezedin Beru, Aysheshim Kassahun

Get full text

Funding liquidity on bank lending growth: The case of India by Erum Shaikh, Muhammad Nawaz Tunio, Vishal Dagar

“…ORIGINALITY AND VALUE: This study makes a significant contribution to the creation of a more in-depth understanding of the potential relationship between banks’ funding liquidity, capital funds, and bankers’ lending behavior, in particular with reference to developing market nations like India.…”
Get full text

P(AN-co-MMA) nanofiber membrane decorated with greenly synthesized nanoparticles for heavy metal removal: a competitive study by Abeer Syed, Enshirah Da’na, Amel Taha, Mohamed R El-Aassar, Adnan M Aldughaish

“…The competitive adsorption behavior of the CoFe _2 O _4 , P(AN-co-MMA), and P(AN-co-MMA)CoFe _2 O _4 was studied to determine their selectivity towards Pb ^2+ , Hg ^2+ , and Cd ^2+ . …”
Get full text

Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome by Xin Tao, Katilynne Croom, Adrian Newman-Tancredi, Mark Varney, Khaleel A. Razak

“…Abstract Background Fragile X syndrome (FXS) is a leading known genetic cause of intellectual disability and autism spectrum disorders (ASD)-associated behaviors. A consistent and debilitating phenotype of FXS is auditory hypersensitivity that may lead to delayed language and high anxiety. …”
Get full text

User Experience of a Semi-Immersive Musical Serious Game to Stimulate Cognitive Functions in Hospitalized Older Patients: Questionnaire Study by Laurent Samson, Lena Carcreff, Frédéric Noublanche, Sophie Noublanche, Hélène Vermersch-Leiber, Cédric Annweiler

“…The level of engagement of the patient throughout the experimental session was also assessed following an internally developed scale, which included 5 levels (interactive, constructive, active, passive, and disengaged behaviors). UX mean scores were computed and presented graphically. …”
Get full text

UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…Further functional studies revealed that overexpression of UBE2J1 promoted cell proliferation, invasion, migration and colony formation, whereas UBE2J1 knockdown attenuated the abovementioned cellular behaviors. Additionally, UBE2J1 overexpression promoted EMT, as evidenced by alterations in the protein expression levels of N-cadherin, snail family transcriptional repressor 2 (Slug), Twist family BHLH transcription factor 1 (Twist 1) and E-cadherin. …”
Get full text

Prevalence and Determinants of Hypertension Awareness, Treatment, and Control in Botswana: A Nationally Representative Population-Based Survey by Neo M. Tapela, Lei Clifton, Gontse Tshisimogo, Moagi Gaborone, Tebogo Madidimalo, Virginia Letsatsi, Tiny Masupe, Mosepele Mosepele, Joseph Makhema, Shahin Lockman, David J. Hunter

“…In this 2014 cross-sectional survey of adults aged 15–69 years, information on sociodemographic characteristics, lifestyle behavior, and medical history was collected through in-person interviews and physical measurements (body mass index and triplicate blood pressure (BP)). …”
Get full text

Lifestyle Intervention Improves Heart Rate Recovery from Exercise in Adults with Type 2 Diabetes: Results from the Look AHEAD Study by Paul M. Ribisl, Sarah A. Gaussoin, Wei Lang, Judy Bahnson, Stephanie A. Connelly, Edward S. Horton, John M. Jakicic, Tina Killean, Dalane W. Kitzman, William C. Knowler, Kerry J. Stewart, Look AHEAD Research Group

Get full text

Exploring Web-Based Support for Suicidal Ideation in the Scottish Population: Usability Study by Heather McClelland, Rory C O'Connor, Laura Gibson, Donald J MacIntyre

“…Engagement with the website was similar to other self-help websites for suicidal ideation; however, more nuanced methods of analyzing website engagement for help-seeking behavior are recommended. Future work would benefit from exploring the effectiveness of this website based on a larger participant sample with website modifications guided by the principles of social learning theory.…”
Get full text

Evaluation of Water Resource Sustainable Utilization in Shandong Province Based on Ecological Footprint and SD Model by HUANG Lixiang, WANG Jianquan, DI Qimeng, QIN Huanhuan

“…Only by making the awareness and behavior of water-saving deeply rooted in people's hearts can we better and more effectively promote the sustainable use of regional water resources.…”
Get full text

Metode Ensemble Classifier untuk Mendeteksi Jenis Attention Deficit Hyperactivity Disorder (SDHD) pada Anak Usia Dini by indri - ati, ari kusyanti

“…Abstract At the beginning of the development stage, some children experience difficulty to calm, to concentrate and to control their behavior. These symptoms are known as ADHD (Attention Deficit Hyperactive Disorder). …”
Get full text

Predictive models for the implementation of targeted reproductive management in multiparous cows on automatic milking systems by Fergus P. Hannon, Martin J. Green, Luke O'Grady, Chris Hudson, Anneke Gouw, Laura V. Randall

“…Automatic milking systems (AMS) allow for the collection of data relating to milk quantity, quality, and robot visit behavior throughout the transition period. In addition to this, auxiliary data sources, such as rumination and activity monitors, as well as historical cow-level data, are often readily available. …”
Get full text