Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits by Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

“…Phenotypic characterization of motor neurons and the neuromuscular junction was performed by immunostaining, microglia were immunohistochemically localized by whole-mount tissue clearing and muscle ultrastructure was analyzed by scanning electron microscopy. Behavior was investigated by video tracking and quantitative analysis of swimming parameters. …”
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Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations by Imad Ed-Dahmani, Mohamed El Fadili, Ghizlane Nouioura, Fahd Kandsi, Yassine El Atki, Hatem A. Abuelizz, Raffaele Conte, Fatima Zahra Lafdil, Abdeslam Taleb, Abdelfattah Abdellaoui, Mustapha Taleb

“…The toxicity study revealed that the mice’s behavior, body weight, and organ weights (liver and kidneys) were unaffected by Ferula communis leaf extract administration compared to controls. …”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Inhibition of platelet activation improved cognitive behaviors in diabetic mice, accompanied with reduced BBB permeability, increased tight junction proteins, balanced Aβ transporters, as well as attenuated Aβ deposition and hippocampal neurons damage. …”
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A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response by Minghan Li, Chang Su, Qianru Wang, Yuetong Chen, Di Jiang, Weijia Wang, Shunjin Chen, Xiangping Li, Ming Fu, Juan Lu

“…Our in vitro experiments confirmed that ZNF32 promotes malignant behavior by driving HNSC cell proliferation and migration. …”
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Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve by Yuanyuan Li, Ruoyao Xu, Muyan Chen, Kaige Zheng, Huimin Nie, Chengyu Yin, Boyu Liu, Yan Tai, Junying Du, Jie Wang, Jianqiao Fang, Boyi Liu

“…Immunostaining, flow cytometry, behavioral assay, in vivo imaging were utilized for effects determination and mechanism exploration. …”
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Building on and tailoring to: Adapting a cancer caregiver psychoeducational intervention for rural settings by Erin E. Kent, Kelly R. Tan, Zev M. Nakamura, Jesse Kovacs, Mindy Gellin, Allison Deal, Eliza M. Park, Maija Reblin

“…These challenges warrant opportunities to participate in evidence‐based behavioral intervention trials to fill support gaps. …”
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Comparing the emotional impact of the UK COVID-19 lockdown in very preterm and full-term born children: a longitudinal study by Zeyuan Sun, Zeyuan Sun, Laila Hadaya, Laila Hadaya, Marguerite Leoni, Marguerite Leoni, Paola Dazzan, Emily Simonoff, Serena J. Counsell, A. David Edwards, Chiara Nosarti, Chiara Nosarti, Lucy Vanes

“…Linear regression model comparisons were conducted to study the effects of COVID-19-related stressors on children's and parents' behavior, relationships and mental health.ResultsThere were no significant group differences in pre-existing SDQ internalizing/externalizing symptoms, child's emotions or parent's emotions during the COVID-19 lockdown. …”
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2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…The nanoLC-Obitrap-MS technology was utilized to detect the content of selected small molecules with differential metabolic activity in the hippocampus and mitochondria of mice to evaluate their permeability through the blood-brain barrier (BBB) and outer mitochondrial membrane. A combination of behavioral, proteomic, and molecular biology approaches was used to explore specific regulatory mechanisms and identify potential pharmacological targets. …”
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Neural Correlates of Social Perception Deficit in Schizophrenia: An Event-related Potential Study by Jiang-juan Li, Xin-ping Li, Jia-min Han, Yi-fan Sun, Xiao-hong Liu, Xue-zheng Gao, Li-min Chen, Zhen-he Zhou, Hong-liang Zhou

“…All participants underwent electroencephalogram recording while completing the Emotion Intensity Recognition Task (EIRT). Behavioral data and ERP components were analyzed using repeated measures analysis of variance. …”
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Multi-Timescale Battery-Charging Optimization for Electric Heavy-Duty Truck Battery-Swapping Stations, Considering Source–Load–Storage Uncertainty by Peijun Shi, Guojian Ni, Rifeng Jin, Haibo Wang, Jinsong Wang, Zhongwei Sun, Guizhi Qiu

“…Uncoordinated large-scale charging behavior can increase operation costs for battery-swapping stations and even affect the stability of the power grid. …”
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Combined oven/freeze drying as a cost and energy-efficient drying method for preserving quality attributes and volatile compounds of carrot slices by Zobabalo Progress Mina, Tafadzwa Kaseke, Tafadzwa Kaseke, Tobi Fadiji, Yardjouma Silue, Olaniyi Amos Fawole, Olaniyi Amos Fawole

“…Combined drying represents a novel approach that addresses the shortcomings of conventional methods by balancing energy consumption, cost, and product quality.MethodsThis study evaluated the impact of combining oven drying (OD) with freeze-drying (FD) on drying behavior, energy requirements, costs, enzyme activity, and the physicochemical and sensory properties of dried carrots. …”
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Petrological controls on the engineering properties of carbonate aggregates through a machine learning approach by Javid Hussain, Tehseen Zafar, Xiaodong Fu, Nafees Ali, Jian Chen, Fabrizio Frontalini, Jabir Hussain, Xiao Lina, George Kontakiotis, Olga Koumoutsakou

“…The analysis identified clay, calcite, feldspar, and dolomite as the primary determinants for the engineering behavior of carbonate aggregates. Although multiple regression analyses produced R² values exceeding 0.84, the multiple regression equations did not provide substantial insights into the impact of all petrographic parameters on engineering properties. …”
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Advanced Amperometric Microsensors for the Electrochemical Quantification of Quercetin in <i>Ginkgo biloba</i> Essential Oil from Regenerative Farming Practices by Elena Oancea, Ioana Adina Tula, Gabriela Stanciu, Raluca-Ioana Ștefan-van Staden, Jacobus (Koos) Frederick van Staden, Magdalena Mititelu

“…In this study, we present a novel approach using amperometric microsensors to detect quercetin in cosmetic formulations and track its metabolic behavior after topical application. This method offers a sensitive, real-time alternative to conventional techniques, enabling the detection of quercetin’s bioavailability, its transformation into active metabolites, and its potential therapeutic effects when applied to the skin. …”
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Traumatic dental injuries in the first year of life and related risk factors in three regions of Brazil: a multicenter birth cohort study by Carlos Alberto Feldens, Bruno Antonio Sehn Konzen, Elisa Maria Rosa de Barros Coelho, Alessandra Castro Alves, Eliane Gerson Feldens, Márcia Regina Vítolo, Paulo Floriani Kramer

“…Socioeconomic, demographic, and anthropometric characteristics were collected at baseline. Behavioral characteristics were collected when the children were six and 12 months of age. …”
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Realizing collective action in agency-constrained contexts: the case of the Community Fish Refuges in Cambodia by Carla Rene Baldivieso Soruco, Carla Rene Baldivieso Soruco, Carla Rene Baldivieso Soruco, Sanjiv De Silva, Pia Gleich, Yin Yan, Mark Dubois, Stefan Sieber, Stefan Sieber, Michelle Bonatti, Michelle Bonatti, Michelle Bonatti

“…This paper delves into a process guided by external agents seeking to reshape local behavior and existing institutional frameworks. Results show how centralized power structures and entrenched rural patronage politics in villages limit villagers’ participation and agency in CFRs management. …”
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Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial by Siyuan Liu, Lan Gao, Yingying Jin, Jiangyun Chen, Dadong Wu, Yiyuan Cai, Tao Wang, Sanhao Huang, Ciling Yan, Run Wang, Dong Roman Xu

“…Rapid Verbal Persuasion (RVP), with highly rapid fashion, has a strong evidence base in promoting behavior change. Despite this, it is underused or rarely evaluated in the context of vaccination. …”
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Urinary incontinence (UI) in older women in low- and middle-income countries: a rapid review and case study from Burkina Faso by Arthi Kozhumam, Mamadou Bountogo, Dina Goodman Palmer, Carolyn Grieg, Carolyn Grieg, Carolyn Grieg, Maxime Inghels, Maxime Inghels, Sandra Agyapong-Badu, Sandra Agyapong-Badu, Cristina Osborne, Guy Harling, Guy Harling, Guy Harling, Guy Harling, Till Bärnighausen, Till Bärnighausen, Till Bärnighausen, David Rapp, David Rapp, Molly Beestrum, Justine Davies, Justine Davies, Justine Davies, Lisa R. Hirschhorn

“…UI prevalence for LMIC women 40 or older varied greatly (6%–80%), with differences by socio-demographics, gynecological factors (menopausal status, birth outcomes), comorbidities (age, education, obesity, diabetes, hypertension, arthritis), behaviors (smoking status) and survey location. The studies used validated tools—the International Consultation on Incontinence Urinary Incontinence Short Form (ICIQ UI-SF) was most common (n = 4, 19%)—and bespoke tools that have not yet been validated. …”
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Analysis of the dynamics of transition from non-colonization to colonization and Staphylococcus aureus bacteremia in hemodialysis patients using Markov models. [version 3; peer rev... by Difariney González-Gómez, J Natalia Jiménez, Johanna M Vanegas, Daniela Montoya-Urrego

“…The aim was to analyze the behavior of S. aureus colonization, identifying the probability of transition from non-colonized to colonized state or bacteremia, and the influence of specific covariates. …”
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Ozone Therapy on Rats Submitted to Subtotal Nephrectomy: Role of Antioxidant System by José Luis Calunga, Zullyt B. Zamora, Aluet Borrego, Sarahí del Río, Ernesto Barber, Silvia Menéndez, Frank Hernández, Teresita Montero, Dunia Taboada

“…In this animal model of CRF, ozone rectal administrations produced a delay in the advance of the disease, protecting the kidneys against vascular, hemorheological, and oxidative mechanisms. This behavior suggests ozone therapy has a protective effect on renal tissue by downregulation of the oxidative stress shown in CRF.…”
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Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis by Shasha Huang, Wanqi Li, Dengke Wang, Huiwen Feng, Bo Wang, Xinyu Dong, Wei Zhao, Dan Liu, Yuan Wang

“…In our study, pregnant Wistar rats were randomly divided into four groups and gavaged at doses of 0, 1, 4 or 10 mg/kg/d DM from gestational day (GD) 0 to postnatal day (PND) 21. We used behavioral experiments and Nissl staining to observe the hippocampal development and learning and memory function of male offspring. …”
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