Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study by Reham Alfaraj, Zainab Alabdulsalam, Zahrah Alfaraj, Hawraa Alsunni, Hussain Alhawaj, Omar Omar, Hatem Abuohashish

“…Wistar rats were divided into four groups: (i) control (Ctrl), (ii) lidocaine intraplantar injection (LIDO), (iii) habitual caffeine intake (CAF), and (iv) lidocaine intraplantar injection and habitual caffeine intake (LIDO + CAF). Behavioral assessments, consisting of a paw pressure test for mechanical pressure sensation and a paw withdrawal latency test for thermal pain sensation, were performed at 0, 30, 60, and 90 minutes following lidocaine injection and after 10, 11, and 12 weeks of CAF intake. …”
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The Relationship between Personality Traits of Temperament and Character and Professional Ethics: The Mediating Role of Psychological Defense Mechanisms by Mohammad Alharabi, Ahmed Alghamdi, Leyla Alghatani

“…Conclusion: This study showed that cognitive and behavioral factors including psychological defense mechanisms and personality traits of temperament and character play a fundamental role in the level of professional ethics of hospital staff.…”
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Exploring the Effects of Tomatidine ((3β, 5α, 22β, and 25β)-Spirosolan-3-ol) on Voltage-gated Na+ currents: Insights Into Its Ionic Mechanisms of Action on Current Magnitude, Gatin... by Tso-Lin Lin, Edmund Cheung So, Sheng-Nan Wu

“…In conclusion, tomatidine enhanced magnitude and modified its gating behaviors.…”
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Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease. by Sydney R Coffey, Robert M Bragg, Shawn Minnig, Seth A Ament, Jeffrey P Cantle, Anne Glickenhaus, Daniel Shelnut, José M Carrillo, Dominic D Shuttleworth, Julie-Anne Rodier, Kimihiro Noguchi, C Frank Bennett, Nathan D Price, Holly B Kordasiewicz, Jeffrey B Carroll

“…This reduction was not associated with alterations in the severity of HD-relevant signs in the striatum of HttQ111/+ mice at the end of the study, including transcriptional dysregulation, the accumulation of neuronal intranuclear inclusions, and behavioral changes such as subtle hypoactivity and reduced exploratory drive. …”
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Mode Optimization and Rule Management of Intellectual Property Rights Protection of Educational Resource Data Based on Machine Learning Algorithm by Jiawei Cao

“…Machine learning takes how computers simulate human learning behaviors as the main research content, which can independently determine learning objects, construct their characteristics, perform additional operations beyond the limitations of preset instructions, and discover value from the expression of relative works. …”
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Enhanced silk production and pupal weight in Bombyx mori through CRISPR/Cas9-mediated circadian Clock gene disruption. by Daniel J Brady, Alessio Saviane, Matteo Battistolli, Irene Varponi, Federica Barca, Kunihiro Shiomi, Silvia Cappellozza, Federica Sandrelli

“…Dysregulation of the circadian clock in ClkΔ29 was demonstrated by altered temporal transcriptional profiles of core circadian clock genes in adult heads and disrupted circadian-controlled behaviors, including adult eclosion and egg hatching rhythms under constant darkness. …”
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Retrospective Analysis of Healthcare Resource Use, Treatment Patterns, and Treatment-related Events in Patients with Huntington’s Disease–associated Chorea Initiated on Tetrabenazi... by Victor W. Sung, Sanjay K. Gandhi, Victor Abler, Brian Davis, Debra E. Irwin, Karen E. Anderson, Ravi G. Iyer

“…**Background:** Huntington’s disease (HD) is a multifaceted neurodegenerative disorder characterized by involuntary movements, specifically chorea, as well as behavioral and psychiatric disturbance, and cognitive dysfunction. …”
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Pervasive systemic disparities: medical-related gaslighting, trauma, and distrust among LGBTQ+ people in the United States by Dustin Z. Nowaskie, Dehandra Blackwood, Frank Garcia

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Validation of the Japanese Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS) by Maiko Takahashi, Jinsoo Koh, Shoko Yorozu, Yoshinori Kajimoto, Yoshiaki Nakayama, Mayumi Sakata, Masaaki Yasui, Yasuhiro Hiwatani, Daniel Weintraub, Hidefumi Ito

“…The Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease (PD)-Rating Scale (QUIP-RS) was developed to assess the severity of impulsive and compulsive behaviors (ICBs) in PD. We aimed to validate the Japanese version of QUIP-RS and determine the characteristics of ICBs in Japan. …”
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The incidence of benign and malignant tumors among adults with long-term physical disabilities by S. Alekova Todorova

“…The harmful impact of a number of behavioral habits and health determinants significantly contributes to this negative tendency.…”
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Enjeux sanitaires, socio-économiques et environnementaux liés à la réutilisation des eaux usées dans le maraîchage urbain : cas du bassin versant de l’Abiergué (Yaoundé-Cameroun)... by Guy Romain Kouam Kenmogne, Francis Rosillon, Hernanie Grelle Mpakam, Alexandre Nono

“…Many practices and many risk behaviors contribute to the spread of waterborne diseases.Despite the risk of waterborne diseases, this activity contributes significantly to food security, strengthening the economic potential, development of urban space in short to improve conditions and the framework of life of the categories of actors involved in this activity in particular and population in general.Actions economically viable, socially acceptable and ecologically sustainable are to be implemented by State or NGO in order to reduce the negative aspects and strengthen the positive aspects of this multipurpose activity.…”
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Close to the border-Resilience in healthcare in a European border region: Findings of a needs analysis. by Leonie A K Loeffler, Sophie Isabelle Lambert, Lea Bouché, Martin Klasen, Saša Sopka, Lina Vogt, COMPAS Consortium

“…<h4>Methods</h4>All hospitals and emergency medical care services in the Euregio Meuse-Rhine (Germany, Belgium, the Netherlands) were approached to participate via an online-survey. Behavioral data on psychological distress (Patient Health Questionnaire-4), work-related stressors, individual resilience (Brief Resilience Scale, Resilience at Work scale), and organizational resilience (Benchmark Resilience Tool-short) were collected.…”
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Obesity and Type 2 Diabetes Prevalence in Adults from Two Remote First Nations Communities in Northwestern Ontario, Canada by Pascal Imbeault, François Haman, Jules M. Blais, Shinjini Pal, Tim Seabert, Eva M. Krümmel, Michael A. Robidoux

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Use of nicotine vaping products during an attempt to quit smoking by Canadian adults who smoke or recently quit: findings from the 2022 Canada International Tobacco Control Four Co... by Shannon Gravely, David Sweanor, Pete Driezen, David T. Levy, Geoffrey T. Fong, Anne C. K. Quah, Lorraine V. Craig, Janet Chung-Hall, Susan C. Kaai, K. Michael Cummings

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The effect of blended education on mental health, academic motivation and academic involvement in students of Payam Noor University by Hossien Najafi, Eisa Jafari, Ali Moghadamzadeh, Ali Salmani

“…Also, the results of the effect of combined training on motivational involvement, cognitive involvement, behavioral involvement and academic engagement (p< 0.01) were also positive and significant. …”
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The link between spreading depolarization and innate immunity in the central nervous system by Kadir Oguzhan Soylu, Muge Yemisci, Hulya Karatas

“…Genetic factors, particularly familial hemiplegic migraine (FHM), exacerbate neuroinflammatory responses to SD, leading to increased susceptibility and prolonged headache behaviors. Collectively, these findings underscore the complex cellular interactions and innate inflammatory processes underlying SD and their relevance to migraine mechanisms, suggesting potential avenues for therapeutic intervention.…”
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Spiritual intelligence: a scoping review on the gateway to mental health by Cristina Teixeira Pinto, Lúcia Guedes, Sara Pinto, Rui Nunes

“…Analysis revealed several notable correlations with SI: resilience (n = 7), general, mental, and spiritual health (n = 6), emotional intelligence (n = 5), and favorable social behaviors and communication strategies (n = 5). Conversely, negative correlations were observed with burnout and stress (n = 5), as well as depression and anxiety (n = 5). …”
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Factors influencing street-vended foods quality and safety in developing countries: a review by O. A. Bassitou Koumassa, Romaric Ouétchéhou, Mathias Hounsou, Oscar Zannou, D. Sylvain Dabadé

“…With concerted efforts, sustained commitment, and behavioral changes from all stakeholders, the availability of safe street food for everyone could be ensured.…”
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Specific features of development of complex-structural model of formation of meaning of life personal strategies in conditions of the armed conflict by Evgeniya N. Ryadinskaya

“…The author proposes a general scheme of recovery areas, which presupposes activity in the political, socio-economic, socio-cultural and psychological areas, and the components of remedial work with civilians in conditions of the armed conflict (physiological, cognitive, emotional, behavioral, personal) have been established as well. …”
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Marked point process variational autoencoder with applications to unsorted spiking activities. by Ryohei Shibue, Tomoharu Iwata

“…In such modeling, the goal is to estimate the joint mark intensity that describes how observed covariates or hidden states (e.g., animal behaviors, animal internal states, and experimental conditions) influence unsorted spikes. …”
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