ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation by Li-Quan Huang, Ting-Xuan Yan, Bao-Sheng Wang, Hao Li, Nai-Bao Zhou

“…Methods: To evaluate the expression of ZC3H15 in cancer-induced pain, we used microcomputed tomography (MicroCT), immunoblotting, co-immunoprecipitation (Co-IP), behavior tests, quantitative real-time polymerase chain reaction (qRT-PCR), and immunofluorescence assays in this investigation. …”
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Evaluation of Dynamic Visual Perception of Riverside Interface in Mountainous Cities from the Perspective of Boating by Dan LUO, Ruhong WEI

“…The subjective and objective visual perception data with respect to eye movement behavior, questionnaire and spatial indicator are integrated. …”
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Modeling Seed Longevity and Percentile Prediction: A Sigmoidal Function Approach in Soybean, Maize, and Tomato by Felipe Souza Carvalho, Brunna Rithielly Rezende, Amanda Rithieli Pereira dos Santos, Maria Márcia Pereira Sartori

“…This study aims to evaluate the behavior of seed longevity in soybean, maize, and tomato stored under controlled conditions using Logistic and Boltzmann sigmoidal models. …”
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Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data by Meghan B. Mitchell, Cynthia R. Cimino, Andreana Benitez, Cassandra L. Brown, Laura E. Gibbons, Robert F. Kennison, Steven D. Shirk, Alireza Atri, Annie Robitaille, Stuart W. S. MacDonald, Magnus Lindwall, Elizabeth M. Zelinski, Sherry L. Willis, K. Warner Schaie, Boo Johansson, Roger A. Dixon, Dan M. Mungas, Scott M. Hofer, Andrea M. Piccinin

“…While the idea that there may be a modifiable behavior that could lower risk for cognitive decline is appealing and potentially empowering for older adults, research findings have not consistently supported the beneficial effects of engaging in cognitively stimulating tasks. …”
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A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points by Anna Procopio, Annarita Tedesco, Fabrizio Lo Regio, Giuseppe Cesarelli, Leandro Donisi, Carlo Ricciardi, Alessio Merola, Alfonso Maria Ponsiglione, Maria Romano, Francesco Montefusco, Carlo Cosentino, Francesco Amato

“…In this context, the present work proposes a general framework to model the dynamics and describe the behavior of a wide class of multivariable physiological control systems, from the molecular to the whole-organ scale. …”
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Sorption and diffusion studies of radiocesium in soil samples from Ibu Kota Nusantara region of Indonesia by Hana Fikrinabilah Dely Supratman, Hendra Adhi Pratama, Budi Setiawan, Mochamad Adhiraga Pratama, Sucipta Sucipta, Sitti Hijraini Nur, Nurul Efri Ekaningrum, Gustri Nurliati, Moh. Cecep Cepi Hikmat, Andry Setiawan, Niken Siwi Pamungkas, Zico Pratama Putra, Muhammad Yusuf

“…These findings highlight the significant impact of soil features in determining the behavior of radio-Cs, which has important implications for strategies related to environmental monitoring and remediation mitigation in IKN region.…”
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A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy by Kelli Scott, Michael J. Mello, Geraldine Almonte, Emely Arenas Lemus, Julie R. Bromberg, Janette Baird, Anthony Spirito, Mark R. Zonfrillo, Karla Lawson, Lois K. Lee, Emily Christison-Lagay, Stephanie Ruest, Jeremy Aidlen, Andrew Kiragu, Charles Pruitt, Isam Nasr, Robert Todd Maxson, Beth Ebel, Sara J. Becker

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Multimodal neural correlates of childhood psychopathology by Jessica Royer, Valeria Kebets, Camille Piguet, Jianzhong Chen, Leon Qi Rong Ooi, Matthias Kirschner, Vanessa Siffredi, Bratislav Misic, BT Thomas Yeo, Boris C Bernhardt

“…Although model parameters yielded statistically significant brain–behavior associations in unseen data, generalizability of the model was rather limited for all three latent components (r change from within- to out-of-sample statistics: LC1within = 0.36, LC1out = 0.03; LC2within = 0.34, LC2out = 0.05; LC3within = 0.35, LC3out = 0.07). …”
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Mitigating overconfidence bias: A cross-sectional pilot study of male maintenance workers in the engineering sector by Luca DI GIAMPAOLO, Federica MARINO, Claudia GIURGOLA, Piergiorgio ASTOLFI, Luca COPPETA, Simone DE SIO, Paola BORRELLI, Teresa GALANTI, Laura FORCELLA, Maria Elisa MAIOLO, Kavita BATRA, Murat YILDIRIM, Hicham KHABBACHE, Amelia RIZZO, Mahmood BAHRAMIZADEH, Hiroo WADA, Qiao NIU, Hector NIETO, Francesco CHIRICO

“…Living arrangements and education influenced attitudes, with workers living with others reporting higher control (p=0.032) and those with high school diplomas showing more positive attitudes (p=0.018). Transgressive behavior correlated with reduced moral norms, positive emotions, and control (all p<0.001). …”
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Phenomenology of Organizational Silence (Case Study Farhangian University) by Iraj Mehdizadeh, Saeed Rajaipour, Seyed Ali Siadat

“…Eliminating discriminatory behaviors and utilizing the capacity of all individuals in proportion to their expertise and skills in university management. …”
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Medical Jousting: Going for the kill! by Dr.Fuad Ahmed Khan Niazi

“…It also needs to be emphasized, that, any medical error or unethical behavior should be reported through proper channels to relevant bodies with the motive to ensure benefit to the patient, and, improvement and development of the involved colleague. …”
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Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels by Cheng Luo, Cheng Luo, Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang, Fan Yang

“…BackgroundFibroblasts in the fibrotic heart exhibit a heterogeneous biological behavior. The specific subsets of fibroblasts that contribute to progressive cardiac fibrosis remain unrevealed. …”
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Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study by Yuqin Rao, Jingjing Wang, Kai Li, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Chen Wang, Bao Liu, Dao Wang

“…Conversely, the number of illnesses (α = -0.089, p < 0.01) and sedentary behavior (α = -0.002, p < 0.05) were negatively associated with physical fitness. …”
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Impact of interventions on mpox transmission during the 2022 outbreak in Canada: a mathematical modeling study of three different cities by Fanyu Xiu, Carla M. Doyle, Jorge Luis Flores Anato, Jesse Knight, Linwei Wang, Joseph Cox, Daniel Grace, Trevor A. Hart, Terri Zhang, Shayna Skakoon-Sparling, Milada Dvorakova, Rita Shahin, Herveen Sachdeva, Nathan Lachowsky, Hind Sbihi, Darrell H.S. Tan, Michael A. Irvine, Sharmistha Mishra, Mathieu Maheu-Giroux

“…We aimed to estimate the relative impact of changes in sexual behaviors, contact tracing/isolation, and first-dose vaccination on transmission in Canadian cities. …”
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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

“…The already existing monitoring infrastructures have provided an enormous amount of hydrometeorological data, facilitating detailed insights into the causal mechanisms of hydrological processes, the testing of scientific theories and hypotheses, and the revelation of the physical laws governing catchment behavior. Yet, hydrological monitoring programs have often produced limited outcomes due to the intermittent availability of financial resources and the substantial efforts required to operate observatories and conduct comparative studies to advance previous findings. …”
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Evaluating the role of environmental advertising on the use of eye movements towards the brand by Seyed Hamid Mir Motahari, Sina Nematizadeh, Seyed Abbas Heydari

“…Eye tracking is a tool for measuring eye position and movements, which can be a useful method for analyzing behavior and cognition (Muñoz-Leiva et al, 2019). By using the eye tracking technique, behavioral evidence can be obtained (Guitart et al, 2018). …”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…However, the selection of the appropriate single-chain variable fragment (scFv) significantly affects the therapeutic efficacy of CAR-T cells by defining their specific behavior towards the target antigen. Therefore, this study aimed to identify the optimal scFv and investigate its biological functions to further optimize the therapeutic potential of CAR-T cells targeting CEA-positive carcinoma.MethodsWe screened four reported humanized or fully human anti-CEA antibodies (M5A, hMN-14, BW431/26, and C2-45), and inserted them into a 3rd-generation CAR structure. …”
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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…En réanimation, l’évaluation de la sédation était faite par l’échelle comportementale Comfort Behavior. L’objectif de l’étude était d’évaluer les effets de l’implémentation d’un algorithme de la sédation sur la durée de ventilation mécanique. …”
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Deep anterior chamber depth may be a risk factor for axial length growth in children by Huijie Cao, Huijie Cao, Yongguo Xiang, Yongguo Xiang, Hong Cheng, Hong Cheng, Kexin Sun, Kexin Sun, Shijie Zheng, Shijie Zheng, Miaomiao Du, Miaomiao Du, Ning Gao, Ning Gao, Tong Zhang, Xin Yang, Jiuyi Xia, Wenjuan Wan, Wenjuan Wan, Ke Hu, Ke Hu

“…Visual habits questionnaire was gained to analyze the correlation between the AL growth and vision-related behavior.ResultsA total of 417 students from Chongqing were enrolled in this study. …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…An early and significant morphological hallmark of HD is the activation of astrocytes triggered by mutant huntingtin, leading to the release of inflammatory mediators.Fingolimod (FTY), an FDA-approved sphingosine-1-phosphate (S1P) receptor agonist is used to treat multiple sclerosis (MS), a neuroinflammatory disease, and has shown therapeutic promise in other neurological conditions.Our study aimed to investigate the therapeutic potential of FTY for treating HD by utilizing a well-characterized mouse model of HD (zQ175dn) and wild-type littermates.The study design included a crossover, long-term oral treatment with 1 mg/kg to 2 mg/kg FTY from the age of 15–46 weeks (n = 128). Different motor behavior and physiological parameters were assessed throughout the study.The findings revealed that FTY rescued disease-related body weight loss in a sex-dependent manner, indicating its potential to regulate metabolic disturbances and to counteract neurodegenerative processes in HD. …”
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