The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats by An Y, Zhang J, Ren Q, Liu J, Liu Z, Cao K

“…Our goal is to systematically analyze and evaluate this efficacy mechanism in migraine treatment-related basic research.Methods: To retrieve animal experiments investigating the action mechanism of acupuncture in migraine treatment, We conducted a literature search in major databases, the search period was the inception of each database to April 1, 2024. …”
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Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization by Jiwei Liu, Lei Wu, Anqi Xie, Weici Liu, Zhao He, Yuan Wan, Wenjun Mao

“…Integrating AI with traditional experimental methods is anticipated to enhance the efficiency and precision of Nb development, expediting the transition from basic research to clinical applications. This review comprehensively examines the latest progress in Nb engineering, emphasizing library construction strategies, display platform technologies, and AI applications. …”
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GLOBAL SCIENCE GOVERNANCE: CASE OF INTERGOVERNMENTAL ORGANIZATIONS by M. V. Kharkevich, M. Yu. Tumanova, D. S. Korobov, S. N. Nedelko

“…The article discusses the role of international government organizations in the governance of global science in the field of basic research. International governmental organizations are viewed primarily as bureaucratic structures, and basic science as club goods or a specific asset that is more effective to manage with the help of hierarchical bureaucratic structures. …”
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Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis by Alessandra Aparecida Marques, Mário Cesar do Nascimento Bevilaqua, Alberto Morais Pinto da Fonseca, Antonio Egidio Nardi, Sandrine Thuret, Gisele Pereira Dias

“…Although the literature reports a higher incidence of anxiety disorders in women, the majority of basic research has focused on male rodents, thus resulting in a lack of knowledge on the neurobiology of anxiety in females. …”
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Direct and Indirect Methods for Studying Human Gut Microbiota by V. T. Ivashkin, O. S. Medvedev, E. A. Poluektova, A. V. Kudryavtseva, I. R. Bakhtogarimov, A. E. Karchevskaya

“…Currently, molecular genetic methods are used mainly for basic research and do not have a unified protocol for data analysis, which makes it difficult to implement them in clinical practice. …”
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Research hotspots and trends in the antioxidant effects of acupuncture: A bibliometric analysis from 2003 to 2024 by Zhilin Huang, Song Li, YiHao Zhou, Anhong Dai, Yi Zhang, Meifang Liu, Mengqi Le, Jing Shi

“…The journals with the most publications (39) and citations (652) are EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. Basic research is the main type of research. Both co-cited literature analysis and keyword examination have indicated neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke, as prominent research domains. …”
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Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside by Sidra Tabassum, Silin Wu, Chang-Hun Lee, Bosco Seong Kyu Yang, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren

“…This review comprehensively examines advancements in mitochondrial-targeted therapies for TBI, bridging the gap from basic research to clinical applications. We discuss the underlying mechanisms of mitochondrial damage in TBI, including oxidative stress, impaired bioenergetics, mitochondrial dynamics, and apoptotic pathways. …”
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Dyadic examination of rumination and depressive symptoms in Chinese heterogeneous young couples: the differential role of gender by Xiaoyu Liu, Anji Zhou, Zhuyun Jin, Zhuo Rachel Han, Jing Qian, Hui Wang

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Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…However, due to the multidirectional differentiation potential and heterogeneity of stem cells, it is difficult to achieve the good efficiency and reproducibility in basic research and clinical applications. This study aims to identify a new strategy for the treatment of TD. …”
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Genetic Markers Can Predict Chondrogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stromal Cells by Masami Kanawa, Akira Igarashi, Katsumi Fujimoto, Yukihito Higashi, Hidemi Kurihara, Masaru Sugiyama, Tania Saskianti, Yukio Kato, Takeshi Kawamoto

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Targeting KRAS‐mutant pancreatic cancer through simultaneous inhibition of KRAS, MEK, and JAK2 by Satoru Miyazaki, Masato Kitazawa, Satoshi Nakamura, Makoto Koyama, Yuta Yamamoto, Nao Hondo, Masahiro Kataoka, Hirokazu Tanaka, Michiko Takeoka, Daisuke Komatsu, Yuji Soejima

“…MRTX1133, a novel KRASG12D inhibitor, has shown promising results in basic research, although its effects against pancreatic cancer are limited when used alone. …”
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Research on comprehensive characterization of deep coal full aperture structure and burial depth effect by Qi Li, Xiaoxia Zhang, Zhengzong Wang, Lei Qiao, Shitan Shao

“…Abstract With the increasing depletion of shallow mineral resources, deep mining has become important; however, basic research on deep resource development remains insufficient, and basic laws are unclear. …”
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A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research by Max L. A. Ebert, Vanessa F. Schmidt, Osman Öcal, Anne von Thaden, Olaf Dietrich, Bastian Popper, Sandra Elges, Max Seidensticker, Jens Ricke, Melanie A. Kimm, Astrid Jeibmann, Moritz Wildgruber

“…While small animal models contain limits for translational research, we aimed to develop an atherosclerosis model with lumen-narrowing plaques to foster basic research in vascular biology, the development of new angioplasty devices, and vessel wall imaging approaches. …”
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A phenomenological study of knowledge concealment in country water and sewage engineering company by Gholamreza Moghadasi, Hamidreza Rezaei Kelidbari, Mohammad Doostar

“…This research is in the basic research category in terms of purpose. The current research was conducted using the qualitative method and based on the phenomenological approach. …”
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Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…Xiping Liao,1,2 Hengqian Liu,3 Yuanyuan Li,1,4 Wei Zhang,1 Qian Dai,1 Haoqi Wei,5 Jianyun Zhou,1 Xia Xie,2 Hongli Zhou1 1Clinical Medical Research Center, The Second Affiliated Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of Gastroenterology, The Second Affiliated Hospital, Army Medical University, Chongqing, People’s Republic of China; 3School of Medicine, Chongqing University, Chongqing, People’s Republic of China; 4Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People’s Republic of China, Chongqing, People’s Republic of China; 5Department of General Surgery, The PLA 77th Group Army Hospital, Leshan City, People’s Republic of ChinaCorrespondence: Xia Xie, Department of Gastroenterology, The Second Affiliated Hospital, Army Medical University, No. 83 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email xiexia0128@tmmu.edu.cn Hongli Zhou, Clinical Medical Research Center, The Second Affiliated Hospital, Army Medical University, No. 83 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email zhouhongli@tmmu.edu.cnBackground: Inflammatory bowel disease (IBD) comprises a group of autoimmune disorders characterized by chronicity and resistance to cure, with an unknown etiology. …”
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High serum CA19-9 predicts severe cholecystitis in calculous cholecystitis patients by Shouwen Wang, Dachen Zhou, Wanjin Chen, Qi Guo, Liujin Hou, Ruolin Wu, Wei Wang, Muhammad Annus Khan, Muhammad Ahmad, Fan Huang, Meijuan Zheng, Guobin Wang, Hongchuan Zhao, Xiaoping Geng, Xiaojun Yu

“…Conclusions This study demonstrated that higher level of serum CA19-9 correlates with more severe cholecystitis in calculous cholecystitis patients for the first time, which will provide helpful information for clinical practice and basic research in related field.…”
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The role of Akkermansia muciniphila in maintaining health: a bibliometric study by Fangfang Gao, Canyu Cheng, Canyu Cheng, Runwei Li, Zongcun Chen, Zongcun Chen, Ke Tang, Guankui Du, Guankui Du, Guankui Du

“…The most cited articles deepened the understanding of the bacterium’s impact on human health, spanning from basic research to translational medicine. Thirty-nine high-frequency keywords were grouped into five clusters, illustrating Akkermansia muciniphila’s associations with metabolic diseases, chronic kidney disease, the gut-brain axis, intestinal inflammation, and Bacteroidetes-Firmicutes shifts.ConclusionGiven Akkermansia muciniphila’s anti-inflammatory and gut-barrier-strengthening properties, it holds promise as a therapeutic for obesity, metabolic disorders, and inflammatory conditions. …”
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Penggunaan Metode Naïve Bayes Classifier pada Analisis Sentimen Penilaian Masyarakat Terhadap Pelayanan Rumah Sakit di Malang by Tsania Dzulkarnain, Dian Eka Ratnawati, Bayu Rahayudi

“…The complaints of the community around the writer regarding the hospital services in Malang make the assessment of hospital services in Malang the subject of this basic research. The author utilizes the Naive Bayes Classifier algorithm and Cross Validation to categorize assessments based on positive and negative sentiments, as well as 4 aspects to facilitate categorization. …”
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Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

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The Role of Cardiopulmonary Exercise Test in IPF Prognosis by Christina Triantafillidou, Effrosyni Manali, Panagiotis Lyberopoulos, Likourgos Kolilekas, Konstantinos Kagouridis, Sotirios Gyftopoulos, Konstantinos Vougas, Anastasia Kotanidou, Manos Alchanatis, Anna Karakatsani, Spyros A. Papiris

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