Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian by Bai-xia Zhang, Jian Li, Hao Gu, Qiang Li, Qi Zhang, Tian-jiao Zhang, Yun Wang, Cheng-ke Cai

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lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587 by Xirui Ma, Ziming Mao, Jing Zhu, Huifang Liu, Fengling Chen

“…We might provide a new target for HCC basic research and clinical management.…”
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Analgesic Mechanism of Sinomenine against Chronic Pain by Wei Jiang, Weiming Fan, Tianle Gao, Tao Li, Zhenming Yin, Huihui Guo, Lulu Wang, Yanxing Han, Jian-Dong Jiang

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Cluster sliding ferroelectricity in trilayer Quasi-Hexagonal C60 by Xuefei Wang, Yanhan Ren, Shi Qiu, Fan Zhang, Xueao Li, Junfeng Gao, Weiwei Gao, Jijun Zhao

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Research Progress on the Effect of Exercise Rehabilitation on Functional Level and Physical Fitness by YIN Lianhua, ZHENG Yan, WU Lijuan, NI Xuling, CHEN Lidian

“…At present, how to choose the best form of exercise rehabilitation and the best course of treatment for people with different functional disorders and different disease status remains to be further clarified by follow-up clinical and basic research.…”
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Current problems of digital transformation in secondary education by V. L. Nazarov, D. V. Zherdev, A. V. Buinacheva

“…The article continues the series of publications within the framework of the Russian Foundation for Basic Research (RFBR) project “Construction of a Fundamental Model for the Digital Transformation of the General Education System”.Aim. …”
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DMF Index among Amelogenesis Imperfecta Patients: Systematic Review of the Literature by Farah Kallel, Amel Labidi, Sana Bekri, Sinda Ammar, Sonia Ghoul, Lamia Mansour

“…The aim of this study was to explore the literature in order to assess systematically the association between amelogenesis imperfecta (AI) and caries development and to evaluate the DMF index among AI patients. Basic Research Design. PubMed was used to explore the database Medline. …”
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Bridging the gap: From petri dish to patient - Advancements in translational drug discovery by Mohamed El-Tanani, Syed Arman Rabbani, Yahia El-Tanani, Ismail I. Matalka, Ikramy A. Khalil

“…Translational research serves as the bridge between basic research and practical applications in clinical settings. …”
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Saponins Effect on Human Insulin Amyloid Aggregation by Eleonora Mari, Silvia Vilasi, Paolo Moretti, Maria Rosalia Mangione, Giorgia Giorgini, Roberta Galeazzi, Maria Grazia Ortore

“…We suggest that saponins, which are natural metabolites present in a wide range of foods ranging from grains, pulses, and green leaves to sea stars and cucumbers, can be promising metabolites to inhibit human insulin aggregation. This basic research work can pave the way to further investigations concerning insulin amyloidosis, suggesting the use of saponins as amyloid inhibitors and/or stabilizing agents in solution.…”
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Testing the Purity of <i>Limnospira fusiformis</i> Cultures After Axenicity Treatments by Michael Schagerl, Alexander Kaptejna, Fabian Polz, Sameh S. Ali, Shuhao Huo, Joana Seneca, Petra Pjevac, Vera Hechtl

“…In phycology, axenic cultures comprising a single living species are commonly strived for both basic research and industrial applications, because contaminants reduce significance for analytic purposes and interfere with the safety and quality of commercial products. …”
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Clinical application of oral Chinese Patent Medicines in ophthalmology: a scoping review protocol by Wei Zhou, Kai Xu, Ziyang Huang, Xiaoyu Li, Xing Liao, Lina Liang, Yamin Li, Qianqian Zuo

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Diffractometer for element-specific analysis on local structures using a combination of X-ray fluorescence holography and anomalous X-ray scattering by Hiroo Tajiri, Shinji Kohara, Koji Kimura, Sekhar Halubai, Haruto Morimoto, Naohisa Happo, Jens R. Stellhorn, Yohei Onodera, Xvsheng Qiao, Daisuke Urushihara, Peidong Hu, Toru Wakihara, Toyohiko Kinoshita, Koichi Hayashi

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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Dehong Wu,1,&ast; Mengdi Yin,2,&ast; Dandan Cao,2,&ast; Xiafeng Zhang,2 Yichun Zhu,2 Ying Wei,2 Yiling Li,2 Chengping Wen,2 Jia Zhou2 1Department of Rheumatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China; 2Institute of Basic Research in Clinical Medicine, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jia Zhou; Chengping Wen, Email zhoujia@zcmu.edu.cn; chengpw2010@126.comBackground: Rheumatoid arthritis (RA) is a chronic autoimmune disease and increasing evidence suggests that disturbances in the composition and function of gut microbiota are potentially implicated in the progression of RA. …”
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Development of the membrane ceiling method for in vitro spermatogenesis by Maki Kamoshita, Hiroki Shirai, Hiroko Nakamura, Tetsuya Kishimoto, Yuki Hatanaka, Daisuke Mashiko, Katsuhiro Esashika, Jingjing Yang, Satoshi Yamasaki, Takehiko Ogawa, Hiroshi Kimura, Masahito Ikawa

“…The device could be used not only for basic research to understand spermatogenesis but also for applied research, such as diagnosing and treating male infertility.…”
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The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats by An Y, Zhang J, Ren Q, Liu J, Liu Z, Cao K

“…Our goal is to systematically analyze and evaluate this efficacy mechanism in migraine treatment-related basic research.Methods: To retrieve animal experiments investigating the action mechanism of acupuncture in migraine treatment, We conducted a literature search in major databases, the search period was the inception of each database to April 1, 2024. …”
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Ascaris lumbricoides a rare cause gastric perforation: a case report and brief literature review by Tian-Hao Xie, Tian-Hao Xie, Yan Fu, Xiang-Xiang Ren, Xin-Li Sun, Qiang Wang, Qian Sun

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Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization by Jiwei Liu, Lei Wu, Anqi Xie, Weici Liu, Zhao He, Yuan Wan, Wenjun Mao

“…Integrating AI with traditional experimental methods is anticipated to enhance the efficiency and precision of Nb development, expediting the transition from basic research to clinical applications. This review comprehensively examines the latest progress in Nb engineering, emphasizing library construction strategies, display platform technologies, and AI applications. …”
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GLOBAL SCIENCE GOVERNANCE: CASE OF INTERGOVERNMENTAL ORGANIZATIONS by M. V. Kharkevich, M. Yu. Tumanova, D. S. Korobov, S. N. Nedelko

“…The article discusses the role of international government organizations in the governance of global science in the field of basic research. International governmental organizations are viewed primarily as bureaucratic structures, and basic science as club goods or a specific asset that is more effective to manage with the help of hierarchical bureaucratic structures. …”
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Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis by Alessandra Aparecida Marques, Mário Cesar do Nascimento Bevilaqua, Alberto Morais Pinto da Fonseca, Antonio Egidio Nardi, Sandrine Thuret, Gisele Pereira Dias

“…Although the literature reports a higher incidence of anxiety disorders in women, the majority of basic research has focused on male rodents, thus resulting in a lack of knowledge on the neurobiology of anxiety in females. …”
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Direct and Indirect Methods for Studying Human Gut Microbiota by V. T. Ivashkin, O. S. Medvedev, E. A. Poluektova, A. V. Kudryavtseva, I. R. Bakhtogarimov, A. E. Karchevskaya

“…Currently, molecular genetic methods are used mainly for basic research and do not have a unified protocol for data analysis, which makes it difficult to implement them in clinical practice. …”
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