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Urinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy
Published 2025-02-01“…From a human health perspective, these data suggest that temperate phages may facilitate bacterial infections rather than function as protective agents. …”
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Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities
Published 2024-11-01“…In recent years, research efforts have increased to develop new therapeutics aimed at combating antibiotic-resistant bacterial infections. These efforts focus on inhibiting the virulence factors bacteria secrete to proliferate. …”
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43
Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications
Published 2025-06-01“…Triazoles are also frequently used in the pharmaceutical industry to treat fungal and bacterial infections as well as to treat and prevent some forms of pneumonia. …”
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Defining and measuring suspicion of sepsis: an analysis of routine data
Published 2017-06-01“…The SOS coding set consists of all bacterial infective diagnoses.Results We identified 47 475 admissions with SOS, equivalent to a rate of 17 admissions per 1000 adults in a given year. …”
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Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment
Published 2025-02-01“…Furthermore, the ZnO@Ag NRs’ antibacterial properties were also confirmed, suggesting additional benefits in treating cancers associated with bacterial infections. Collectively, these findings establish ZnO@Ag NRs as a potent and safe agent for ultrasound-driven cancer therapy.…”
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Combating antibiotic resistance: mechanisms, challenges, and innovative approaches in antibacterial drug development
Published 2025-01-01“…As bacteria adapt to evade current drugs, managing bacterial infections has become increasingly challenging, leading to prolonged illnesses, higher healthcare costs, and increased mortality. …”
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Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing
Published 2025-04-01“…Wound care always presents challenges as they are susceptible to bacterial infections and have mechanical compatibility issues with wound dressings, leading to a delayed recovery of the structure and functional integrity of skin tissue. …”
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In vitro investigations of coelomic fluid of Eisenia fetida: protein analysis, antioxidant activities and antibacterial effects on diabetic wounds' bacteria
Published 2025-02-01“…Diabetic wounds are prone to bacterial infections, with common pathogens including Staphylococcus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa. …”
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Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications
Published 2021“…They are routinely used to treat bacterial infections and to prevent infections in patients with compromised immune systems and enhancing growth in livestock. …”
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Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis
Published 2025-02-01“…Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections. Herein, we developed a close-packed and ordered Au@AgPt array coupled with a cascade triggering strategy for surface-enhanced Raman scattering (SERS) and colorimetric identification of the Staphylococcus aureus biomarker micrococcal nuclease (MNase) in serum samples. …”
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Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella
Published 2025-02-01“…Collectively, our work opens new avenues toward the potentiation of COL and reveals an alternative drug combination strategy to overcome COL-resistant bacterial infections.…”
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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency
Published 2025-02-01“…Despite the antimicrobial activities of α-defensins by direct bacterial killing and by modulation of immune responses, AATD individuals are paradoxically burdened by recurrent exacerbation triggered by bacterial infections, frequently with nontypeable Haemophilus influenzae (NTHi). …”
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Implementation of a rapid host-protein diagnostic test for distinguishing bacterial and viral infections in adults presenting to urgent care centers: a pragmatic cohort study
Published 2025-02-01“…MMBV indicated 405/3262 (12.4%) cases of potentially missed bacterial infections. Physicians prescribed antibiotics to 283/405 (69.9%). …”
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Design and assessment of lipase-CuO nanoparticle conjugates for enhanced antimicrobial efficacy against clinical pathogens
Published 2025-02-01“…These findings suggest that Lipase-CuO nanoparticle conjugates hold great promise as a novel antimicrobial strategy, offering a potential solution to combat bacterial infections, especially those caused by multidrug-resistant strains. …”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity
Published 2025-05-01“…Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. …”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins
Published 2025-02-01“…Antivirulence drugs offer a new approach to treating bacterial infections by targeting specific virulence factors without affecting bacterial growth, thus helping to combat infection without exerting selective pressure on bacteria or inducing resistance. …”
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The characteristics of dermatology inpatients seen at the quaternary Inkosi Albert Luthuli Central Hospital in Durban, South Africa, over a 5-year period – 2015 - 2020
Published 2023-12-01“…Most (1 010 (20.7%)) of the dermatology consults were received from plastic and reconstructive surgeons, while bacterial infections, decubitus ulcers and lower limb ulcers were the three most common referred diagnoses overall. …”
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Anti-motilities and anti-biofilm effects of Ageratum conyzoides L. methanol extract
Published 2025-01-01“…Contribution: This study provided additional scientific evidence to support the use of A. conyzoides in traditional medicine against bacterial infections.…”
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Comparison of chromogenic and cysteine lactose electrolyte deficient agar for identification of uropathogens in Gujarat, India
Published 2025-02-01“…Background: Urinary tract infections (UTIs) are prevalent bacterial infections, necessitating rapid and accurate diagnosis for timely treatment. …”
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Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
Published 2025-02-01“…Abstract Background Neutrophil granulocytes are important parts of the defence against bacterial infections. Their action is a two-edged sword, the mediators killing the intruding bacteria are at the same time causing tissue damage. …”
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