Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients by Qi Sun, Qingsong Lin, Yanxia Lv, Zhiying Tian, Qiushuang Yan, Yaqing Yu, Xue Fu, Hongjing Yao, Fujun Sun, Yonghui Xia, Guoqing Zhu, Sizhou Feng

“…The main infected strains were Escherichia coli (n = 84, 21%), Klebsiella pneumoniae (n = 61, 15.25%) and Pseudomonas aeruginosa (n = 65, 16.25%), and the increasing trend of PCT level was more obvious in patients infected with Gram-negative bacteria. ROC analysis results showed that the area under the receiver operating characteristic curve for distinguishing bacterial infection from non-bacterial infection was 0.554 (95%CI: 0.522–0.585) with the diagnostic threshold of BSI (PCT > 0.5ng/mL). …”
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Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Benediktus Yohan Arman, Rebecca Clarke, Tehmina Bharucha, Laura Gomez Fernandez, John Walsby-Tickle, Michael Deats, Sara Mosca, Qianqi Lin, Sneha Banerjee, Shrikrishna R. Chunekar, Kundan D. Patil, Sunil Gairola, Susanna Dunachie, Hamid A. Merchant, Robert Stokes, Rutendo Kuwana, Alexandrine Maes, Jean-Philippe Charrier, Fay Probert, Céline Caillet, Pavel Matousek, James McCullagh, Paul N. Newton, Nicole Zitzmann, Bevin Gangadharan

“…In this context, matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS) is globally available for fast and accurate analysis of bacteria in patient samples, offering a potentially accessible solution to identify SF vaccines. …”
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Klebsiella pneumoniae induces dose-dependent shock, organ dysfunction, and coagulopathy in a nonhuman primate critical care model by Jeffrey R. Strich, Marcos J. Ramos-Benitez, Seth Warner, Heather Kendall, Sydney Stein, Andrew P. Platt, Sabrina C. Ramelli, Shelly J. Curran, Izabella Lach, Kiana Allen, Ashley Babyak, Luis J. Perez-Valencia, Mahnaz Minai, Junfeng Sun, Kevin M. Vannella, Derron Alves, Richard Herbert, Daniel S. Chertow

“…In this study, we developed a model of septic shock with a clinically relevant bacteria (Klebsiella pneumoniae) that provides standard supportive care including mechanical ventilation, invasive hemodynamic monitoring, volume resuscitation, vasopressors, antibiotics, and steroids. …”
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Physical and molecular identification of fish and shrimp diseases in some farms of West Java, Banten and Jakarta, Indonesia by Adam Saba Anggara, Ida Ayu Mirah Meliana Dewi, Kismono Kudoasmoro, Putu Eka Sudaryatma, Putu Angga Wiradana

“… Infectious disease is a major challenge in fish and shrimp farming systems caused by microorganisms including bacteria, viruses and parasites. Physical detection has limitations in detecting diseases in cultivated animals earlier, because of the varied clinical symptoms. …”
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Regional antimicrobial resistance gene flow among the One Health sectors in China by Yuqing Feng, Xin Lu, Jiayong Zhao, Hongmin Li, Jialiang Xu, Zhenpeng Li, Mengyu Wang, Yao Peng, Tian Tian, Gailing Yuan, Yuan Zhang, Jiaqi Liu, Meihong Zhang, A La Teng Zhu La, Geruo Qu, Yujiao Mu, Wanshen Guo, Yongning Wu, Yuyu Zhang, Dexiang Wang, Yongfei Hu, Biao Kan

“…The widespread mobile carbapenemase gene, OXA-347, carried by non-Enterobacteriaceae bacteria in the human gut microbiota, requires particular attention. …”
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Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity by Wen-lin Pang, Wen-lin Pang, Tian-gang Li, Tian-gang Li, Yin-ying Wang, Yin-ying Wang, Li-yun Song, Li-yun Song, Li Li, Li Li, Xiao-ya Li, Xiao-ya Li, Yong Qiu, Yong Qiu, Zhong-shan Yang, Zhong-shan Yang

“…In addition, analysis of 16S rRNA gene sequencing indicated that SC reduced harmful bacterial populations, such as Proteobacteria, while simultaneously enhancing the levels of beneficial bacteria like Lactobacillus, thereby contributing to the improvement of UC pathology.ConclusionThis study highlights the therapeutic potential of SC in managing UC through its ability to attenuate inflammatory responses, restore intestinal barrier functionality, and modulate gut microbiota composition, which findings offer insights into potential strategies for advancing UC treatment.…”
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Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential by Ines Hadrich, Mariem Turki, Mariem Turki, Imen Chaari, Imen Chaari, Balkiss Abdelmoula, Rahma Gargouri, Nahed Khemakhem, Dhawia Elatoui, Fatma Abid, Sonda Kammoun, Sonda Kammoun, Mona Rekik, Mona Rekik, Samir Aloulou, Samir Aloulou, Mariem Sehli, Mariem Sehli, Aymen Ben Mrad, Aymen Ben Mrad, Sourour Neji, Fabian M. Feiguin, Jihene Aloulou, Jihene Aloulou, Nouha Bouayed Abdelmoula, Hayet Sellami, Hayet Sellami

“…BackgroundThe human gut mycobiome, a minor but integral component of the gut microbiome, has emerged as a significant player in host homeostasis and disease development. While bacteria have traditionally been the focus of gut microbiome studies, recent evidence suggests that fungal communities (mycobiota) may also play a crucial role in modulating health, particularly in neuropsychiatric disorders.ObjectiveThis review aims to provide a comprehensive overview of current knowledge on the relationship between the gut mycobiome and neuropsychiatric disorders, exploring the potential of targeting fungal communities as a novel therapeutic strategy.MethodsWe summarized recent findings from metagenomic analyses that characterize the diversity and composition of gut mycobiota and discuss how these communities interact with the host and other microorganisms via the gut-brain axis. …”
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Case report: A novel de novo germline loss-of-function mutation in the STAT1 transactivation domain in two Chinese siblings, with the elder sibling presenting with multifocal Bacil... by Qin Ying Lim, Qin Ying Lim, Daniel Leung, Crystal K. Lam, Xingtian Yang, Kai N. Cheong, Kai N. Cheong, Andrew K. H. Yik, Jing Yang, Koon-Wing Chan, Pamela P. W. Lee, Pamela P. W. Lee, Pamela P. W. Lee, Pamela P. W. Lee, Miyuki Tsumura, Elaine Y. L. Au, Jaime S. Rosa Duque, Jaime S. Rosa Duque, Jaime S. Rosa Duque, Satoshi Okada, Yu Lung Lau, Yu Lung Lau, Yu Lung Lau

“…Individuals with autosomal dominant STAT1 deficiency are more susceptible to intracellular bacteria, the hallmark of which is Mendelian susceptibility to mycobacterial diseases (MSMDs) that are associated with increased risks of invasive disease by weakly virulent mycobacteria. …”
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Isolation and Characterization of Indigenous <i>Acetobacter</i> Strains from Cashew Apple and Their Potential Use in Vinegar Production by Yaya Anianhou Ouattara, Doudjo Soro, Kouakou Romain Fossou, Ahou Cinthia Ines Yebouet, Ismael Abraham Cissé, Dogbo Marius Akissi, Adolphe Zézé, Emmanuel Assidjo, Kouassi Benjamin Yao

“…Vinegar mother from fermented juice was used to isolate acetic acid bacteria on a standard glucose-based medium. Physiological and biochemical tests followed by 16S rRNA gene analysis and phylogeny were used for isolate characterization. …”
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Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites by Mauricio Piñeiro, Mauricio Piñeiro, Sofía Manrique, Jessica Gómez, Jessica Gómez, Juan Manuel Rodriguez, Patricia Barrera, Duilio Caballero, Miguel A. Sosa, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Alejandro Tapia, Beatriz Lima, Beatriz Lima, Mario J. Simirgiotis

“…Regarding the antimicrobial activity, the results showed that all bacteria and yeasts tested were inhibited by the different extracts with minimum inhibitory concentration (MIC) values between 25 μg/mL and 500 μg/mL. …”
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Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing by Fuqiang Song, Anqi Ye, Linyuan Jiang, Yang Lu, Yanzhen Feng, Rong Huang, Siting Du, Xiaoyu Dong, Ting Huang, Ping Li, Liangliang Yang, Jinjing Zhang, Mengjia Xu, Li Cheng, Jian Xiao

“…Near-infrared-assisted heating provides noninvasive, targeted hyperthermia, killing bacteria quickly. Post-PTT addition of low-dose AgNCs reduces toxicity while enhancing antimicrobial efficacy and biocompatibility. …”
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Unraveling the degradation mechanism of multiple pyrethroid insecticides by Pseudomonas aeruginosa and its environmental bioremediation potential by Hui Liu, Wen-Juan Chen, Zeling Xu, Shao-Fang Chen, Haoran Song, Yaohua Huang, Kalpana Bhatt, Sandhya Mishra, Mohamed A. Ghorab, Lian-Hui Zhang, Shaohua Chen

“…Strain PAO1 displayed a synergistic effect with local degrading bacteria or flora to degrade etofenprox. UPLC-MS/MS analysis identified 2-(4-ethoxyphenyl) propan-2-ol and 3-phenoxybenzoic acid as the major metabolites of etofenprox biodegradation. …”
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Core microbe Bifidobacterium in the hindgut of calves improves the growth phenotype of young hosts by regulating microbial functions and host metabolism by Yimin Zhuang, Duo Gao, Wen Jiang, Yiming Xu, Guanglei Liu, Guobin Hou, Tianyu Chen, Shangru Li, Siyuan Zhang, Shuai Liu, Jingjun Wang, Jianxin Xiao, Mengmeng Li, Wei Wang, Shengli Li, Zhijun Cao

“…However, the identification of beneficial gut bacteria and its internal mechanisms of shaping host phenotype differentiation remains unclear. …”
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Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

“…Significant variations in metabolites were observed among different microbial strains. Bacteria exhibited proficiency in amino acid synthesis, while fungi were actively involved in amino acid metabolism, transcription, and expression processes. …”
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Grain Yield Stability Analysis of Lentil Genotypes by AMMI Indices by Payam Pezeshkpour, Reza Amiri, Iraj Karami, Amir Mirzaei

“…Extended Abstract Background: Due to the presence of nitrogen-fixing bacteria in its roots, the lentil plant causes biological nitrogen fixation, and in addition to meeting the plant's need for this substance, they also add some pure nitrogen to the soil each year. …”
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A combined use of Panax ginseng extract and the probiotic, Lactobacillus plantarum in the diet of Asian seabass, Lates calcarifer: Effects on growth, immunity and survival after ba... by Xiaojie Hou, Jianfeng Zhang, Neda Behmagham, Hamed Ghafarifarsani

“…The intestinal lactic acid bacteria with maximum load of 4.1 ± 0.5, 3.9 ± 0.5 and 3.6 ± 0.4 log CFU/g intestine at LAC-P + GINS treatments, increased, following the probiotic administration, while total bacterial count remained unchanged (P < 0.01). …”
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Oral administration of pioglitazone inhibits pulmonary hypertension by regulating the gut microbiome and plasma metabolome in male rats by Zizhou Zhang, Yaru Liang, Shaocong Mo, Mingming Zhao, Yi Li, Chenting Zhang, Xiaoqian Shan, Shiyun Liu, Jing Liao, Xiaoyun Luo, Junqi Zhu, Chen Wang, Qian Jiang, Chi Hou, Wei Hong, Ning Lai, Yuqin Chen, Lei Xu, Wenju Lu, Jian Wang, Zhongfang Wang, Kai Yang

“…Correlation analyses represented strong and unique association between the protective metabolites and bacteria genera (Roseburia, Lactobacillus, and Streptococcus) that were positively stimulated by pioglitazone. …”
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Diagnosis and treatment of the irritable bowel syndrome: clinical guidelines of the Russian gastroenterological association and Russian association of coloproctology by V. T. Ivashkin, Yu. A. Shelygin, Ye. K. Baranskaya, Ye. A. Belousova, A. G. Beniashvili, S. V. Vasilyev, A. O. Golovenko, O. V. Golovenko, Ye. G. Grigoryev, N. V. Kostenko, T. L. Lapina, I. D. Loranskaya, O. S. Lyashenko, I. V. Mayev, Ye. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, A. S. Trukhmanov, O. Yu. Fomenko, I. L. Khalif, E. Yu. Chashkova, A. A. Sheptulin, O. S. Shifrin, V. V. Yanovoy

“…Due to complexity of differential diagnostics, IBS should be considered as diagnosis by exclusion that require following investigations: clinical and biochemical blood tests; IgA or IgG anti-tissue transglutaminase antibodies; thyroid hormone levels; fecal occult blood test; glucose or lactulose hydrogen breath test for bacterial overgrowth syndrome; stool test for coliform bacteria, stool test for Clostridium difficile toxins A and B; fecal calprotectin level; abdominal ultrasound; upper and lower endoscopies, at indications - with biopsies. …”
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Therapeutic efficacy of LysGH15 against necrotising pneumonia caused by Staphylococcus aureus in a rabbit model by Bowei Zhang, Liran Song, Yongran Wang, Meimei Zhang, Chong Chen, Hui Ning, Li Wang, Cao Qiu, Xinwu Wang, Changjiang Sun, Xin Feng, Wenyu Han, Wenyu Han, Bin Wang, Yalu Ji, Jingmin Gu, Jingmin Gu

“…At 72 h postinfection, the number of bacteria in the lung tissues of the rabbits treated with LysGH15 was 7 × 104 CFU/g, which was significantly lower than that in the lung tissues of rabbits treated with PBS (7.76 × 106 CFU/g) or linezolid (6.38 × 105 CFU/g). …”
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Whole genome sequencing of a novel carrageenan-degrading bacterium Photobacterium rosenbergii and oligosaccharide preparation by Jing Chen, Jing Chen, Runmin Chen, Kit-Leong Cheong, Zhuo Wang, Rui Li, Xuejing Jia, Qiaoli Zhao, Xiaofei Liu, Bingbing Song, Saiyi Zhong, Saiyi Zhong

“…In addition, there are no current reports of bacteria of the genus Photobacterium capable of secreting κ-carrageenanase or degrading carrageenan.MethodsIn the current study, strain GDSX-4 was obtained from Gracilaria coronopifolia after enrichment culture, primary screening and rescreening and was initially characterized by morphology and 16SrDNA. …”
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