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121
Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice
Published 2025-02-01“…Results: We detected MCT8 protein expression in sciatic nerve axons, whereas OATP1C1 expression was observed in a subset of endothelial cells early in postnatal development. …”
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122
The Development of Methods of BLOTCHIP<sup>®</sup>-MS for Peptidome: Small Samples in Tuberous Sclerosis
Published 2025-01-01“…Mutations in TSC1 or TSC2 in axons induce tuberous sclerosis complex. Neurological manifestations mainly include epilepsy and autism spectrum disorder (ASD). …”
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123
Derivation and Identification of Motor Neurons from Human Urine-Derived Induced Pluripotent Stem Cells
Published 2018-01-01“…Furthermore, in coculture with muscle cells, MNs projected long axons and formed neuromuscular junctions (NMJs). …”
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124
Neurofilament Light Chain Assessment in Type 2 Diabetic Patients with Distal Symmetrical Polyneuropathy
Published 2025-01-01“… Background: A neuron-specific cytoskeletal protein called Neurofilament light chain is present in the cytoplasm of myelinated axons especially those with a large diameter which is essential for maintaining the size as well as for structural support. …”
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125
Short Pulse Epiretinal Stimulation Allows Focal Activation of Retinal Ganglion Cells
Published 2025-01-01“…Axonal thresholds were significantly higher for all pulse durations, with the ratio between axonal and somatic thresholds strongly increasing with decreasing pulse duration (1.32 and 4.39 for pulse durations of 500 and <inline-formula> <tex-math notation="LaTeX">$10\mu $ </tex-math></inline-formula>s, respectively). …”
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126
Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise
Published 2016-01-01“…To investigate the climb stairs resistance exercise on nociception and axonal regeneration in the sciatic nerve of rats. …”
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127
Finite Element Modelling for Biophysical Models of Nervous System Stimulation: Best Practices for Multiscale Adaptive Meshing
Published 2025-01-01“…We advocate coupling the extracellular field to H-H-based axons to further limit potential error sources.…”
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128
Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway
Published 2019-01-01“…Glaucoma is characterized by progressive, irreversible damage to the retinal ganglion cells (RGCs) and their axons. Our previous study has shown that the intravitreal transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) reveals a neuroprotective role in microsphere injection-induced ocular hypertension (OHT) rat models. …”
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129
Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis
Published 2025-01-01“…IntroductionRemyelination of demyelinated axons can occur as an endogenous repair mechanism in multiple sclerosis (MS), but its efficacy varies between both MS individuals and lesions. …”
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130
A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots
Published 2025-01-01“…BackgroundOptic atrophy (OA) is primarily caused by damage to the retinal pathway system, including widespread degeneration of retinal ganglion cells and axons, leading to visual impairment and blindness. …”
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131
Role of neuroinflammation in the pathogenesis of glaucomatous optic neuropathy
Published 2022-05-01“…Additionally, these cells secrete fibrillar proteins that regenerate the extracellular matrix but form a glial scar, thereby inhibiting axonal transport and limiting t he regeneration of damaged axons. …”
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132
In vivo scanning laser fundus and high-resolution OCT imaging of retinal ganglion cell injury in a non-human primate model with an activatable fluorescent-labeled TAT peptide probe...
Published 2024-01-01“…Compared to rodents, unexpectedly rapid axonal transport in the NHPs reduced the capacity to visualize RGC cell bodies and axons through the backdrop of an intravitreal haze. …”
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133
The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection
Published 2015-01-01“…Functional recovery following spinal cord injury (SCI) is limited by poor axonal and cellular regeneration as well as the failure to replace damaged myelin. …”
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134
Morphometric and Growth Pattern Analysis of Corpus Callosum in Paediatric Population on Magnetic Resonance Imaging: A Retrospective Observational Study
Published 2025-01-01“…Introduction: There is development and myelination of axons within the Corpus Callosum (CC) in children and early adulthood, causing modifications in its various dimensions. …”
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135
Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction
Published 2025-01-01“…Meanwhile, the decelerating axons exhibit excellent alignment and remyelination, thereby helping to prevent failure modes in nerve self-organization, such as axonal twisting in congested regions and overgrowth beyond the conduit’s capacity. …”
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136
The Impact of Optical Undersampling on the Ca2+ Signal Resolution in Ca2+ Imaging of Spontaneous Neuronal Activity
Published 2025-01-01“…Small-amplitude Ca2+ transients, undetectable at 14 Hz, became evident at 500 Hz, particularly in the neuropil (putative dendrites and axons), but not in nearby cell bodies. Large Ca2+ transients exhibited greater amplitudes and faster temporal dynamics in dendrites compared with somas, potentially due to the higher surface-to-volume ratio of dendrites. …”
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137
Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation
Published 2024-07-01“…In this context, extracellular vesicles (EVs) can contribute to intercellular communication, stimulating the production of proteins and lipids associated with remyelination and providing trophic support to axons. This study aimed to evaluate the therapeutic efficacy of the combination of NSCs and EVs derived from oligodendrocyte precursor cells (OPCs) in an animal model of multiple sclerosis. …”
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138
Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
Published 2020-01-01“…We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.…”
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139
Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach
Published 2013-01-01“…Lymphocytes activated in the periphery infiltrate the central nervous system to trigger a local immune response that ultimately damages myelin and axons. Pro-inflammatory cytokines amplify the inflammatory cascade by compromising the BBB, recruiting immune cells from the periphery, and activating resident microglia. inflammation-associated oxidative burst in activated microglia and macrophages plays an important role in the demyelination and free radical-mediated tissue injury in the pathogenesis of MS. …”
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140
Sex-based differences in the long-term fate of hippocampal neurons born after a traumatic brain injury
Published 2025-02-01“…Neurons born after injury extended axons which formed synaptic terminals within the CA3 region. …”
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