E46K α-Synuclein Mutation Fails to Promote Neurite Outgrowth by Not Inducing Cdc42EP2 Expression, Unlike Wild-Type or A53T α-Synuclein in SK-N-SH Cells by Hyunja Jung, Seonghan Kim

“…Conclusions: Our findings suggest that WT and mutant α-syn are linked to Cdc42EP2 production in neuritogenesis, implying α-syn involvement in the physiological function of axon growth and synapse formation. Thus, α-syn may be a potential therapeutic target for PD.…”
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Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus by Nimat Abuelwafaa, Hana Ahmed, Ilham Omer, Mohamed Abdullah, Ammar Ahmed, Afraa Musa

“…Diabetic peripheral neuropathy (DPN) involves sensory and motor nerves, resulting in demyelination as well as axonal degeneration. This study was conducted to describe the pattern of lower limb nerve involvement in children with type 1 diabetes mellitus (DM) based on the parameters of nerve conduction study (NCS). …”
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Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor by M. Satue, L. Jarauta, J. Obis, M. Cipres, M. J. Rodrigo, C. Almarcegui, I. Dolz, J. R. Ara, J. Martin, L. E. Pablo, E. Garcia-Martin

“…This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.…”
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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation by Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

“…Thus, biomimetic ECM NGCs offer a therapeutic strategy for peripheral nerve regeneration with promising clinical applications and transformation prospects to regulate immune microenvironments, promoting SC proliferation and differentiation with nerve axon growth.…”
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Filamented hydrogels as tunable conduits for guiding neurite outgrowth by Hao Liu, Anna Puiggalí-Jou, Parth Chansoria, Jakub Janiak, Marcy Zenobi-Wong

“…While significant differences in neurite outgrowth and alignment were observed between bulk and FLight gels, further increases in porosity from 40 % to 70 % enhanced cell migration and axon bundling without significantly affecting maximal outgrowth. …”
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Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…Overall, iHPN is a novel injectable hydrogel that has potential for minimally invasive CNS applications, such as a carrier for cell or drug delivery and/or a biomaterial to support axonal growth.…”
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Severe Guillain-Barré syndrome with concurrent optic neuritis in a pediatric patient: a case report by Xin Xue, Yingcun Bao, Yakun Yu, Qun Li, Mei Liu, Xiaoling Li

“…Neurophysiological studies indicated widespread demyelinating and axonal damage.Interventions and outcomesThe patient received intravenous immunoglobulin (IVIG) therapy, high-dose corticosteroids, and, given the severe progression, rituximab. …”
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UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles in the absence of the motor's PH domain by Odvogmed Bayansan, Prerana Bhan, Chien-Yu Chang, Syed Nooruzuha Barmaver, Che-Piao Shen, Oliver Ingvar Wagner

“…Kinesin-3 KIF1A (UNC-104 in C. elegans) is the major axonal transporter of synaptic vesicles and mutations in this molecular motor are linked to KIF1A-associated neurological disorders (KAND), encompassing Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis and hereditary spastic paraplegia. …”
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Chronic restraint stress affects the diurnal rhythms of gut microbial composition and metabolism in a mouse model of depression by Yue Wang, Peijin Cui, Maolin Cao, Ling Ai, Li Zeng, Xue Li, Dan Chen, Fang Gong, Liang Fang, Chanjuan Zhou

“…In the CRS group, Bacteroides, Parabacteroides, and Rikenellaceae_RC9_gut_group showed circadian rhythmicity; among these genera, Parabacteroides was related to tryptophan metabolism, axon regeneration, phenylalanine metabolism and tyrosine metabolism. …”
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Neurofilament light chain (Nf-L) in cerebrospinal fluid and serum as a potential biomarker in the differential diagnosis of neurological diseases in cattle by Giorgia Di Muro, Carlotta Tessarolo, Giulia Cagnotti, Alessandra Favole, Sara Ferrini, Ugo Ala, Claudio Bellino, Giuliano Borriello, Marina Gallo, Giulia Iamone, Barbara Iulini, Marzia Pezzolato, Cristina Casalone, Maria Caramelli, Lorenzo Capucci, Patrizia Cavadini, Cristiano Corona, Antonio D’Angelo

“…Abstract Neurofilament light chain (Nf-L) is a biomarker for axonal damage in human neurology but is understudied in cattle. …”
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Guillain-Barré syndrome following falciparum malaria infection: a case report by Molla Asnake Kebede, Alemayehu Beharu Tekle, Misikir Alemu Eshetu, Erkyehun Pawlos Shash, Melaku Tsediew Berhanu, Elias Tabiet Ahmed, Hashime Meketa Negatie

“…Although the specific subtype (demyelinating or axonal) was not determined in this case due to the absence of a nerve conduction study, demyelinating subtypes have been found in GBS following Plasmodium infection. …”
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Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation by María del Pilar Diego-Santiago, María Ujué González, Esther María Zamora Sánchez, Nuria Cortes-Carrillo, Carlos Dotti, Francesc Xavier Guix, Sahba Mobini

“…Increased accumulated charge facilitates the development of complex neuronal morphologies and axonal ramification, outperforming exogenous neurotrophic factors. …”
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Research Progress of Nerve Mobilization in Basic and Clinical Rehabilitation by Shuo LUAN, Quanshou LING, Miaoshang ZENG, Anni LIN, Yingping JIANG

“…The curative effects and related mechanisms, including anti-inflammation, increased axonal transport efficiency and nerve tissue regeneration deserve more future investigations. …”
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Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…The differentially expressed genes were affected for small cell lung cancer, axon guidance, Fc gamma R-mediated phagocytosis, MAPK signaling pathway, focal adhesion, insulin resistance, and metabolic pathways. …”
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Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences by Joan Y Song, Roman Fleysher, Kenny Ye, Mimi Kim, Molly E Zimmerman, Richard B Lipton, Michael L Lipton

“…Conclusion: The inverse association of slope magnitude with age indicates loss of the sharp GWI transition in aging, which is consistent with processes such as dendritic pruning, axonal degeneration, and inflammation. This method overcomes techniques issues related to interrogating the GWI. …”
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Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice by Ethan P. Glaser, Timothy J. Kopper, William M. Bailey, Hassan K. Kashif, Reena Kumari, Andrew N. Stewart, John C. Gensel

“…We also evaluated tissue sparing and intralesional axon density six weeks after injury. cPLA2 KO chimeras did not display altered locomotor recovery or tissue pathology after SCI compared to WT chimera controls. …”
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Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism by Kelley C. Larson, Frederick W. Gergits, Abigail J. Renoux, Elizabeth J. Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G. McLaren, Berkley A. Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Mirescu

“…Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP). …”
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Development of single-pin, un-barbed, pole-tagging of free-swimming dolphins and sharks with satellite-linked transmitters by Michael J. Moore, Thomas M. Lanagan, Randall S. Wells, Jason Kapit, Aaron A. Barleycorn, Jason B. Allen, Robin W. Baird, Camrin D. Braun, Gregory B. Skomal, Simon R. Thorrold

“…Delphinid skin has unique polymodal axon bundles that project into the epidermis, perhaps a factor in their uniquely fast response, which is 10 × faster than humans. …”
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Effects of Alzheimer’s disease plasma marker levels on multilayer centrality in healthy individuals by Alejandra García-Colomo, David López-Sanz, Ignacio Taguas, Martín Carrasco-Gómez, Carlos Spuch, María Comis-Tuche, Fernando Maestú

“…We aimed to address the relationship between centrality network changes and two plasma pathology markers: phosphorylated tau at threonine 231 (p-tau231), a proxy for early Aβ change, and neurofilament light chain (Nfl), a marker of axonal degeneration. Methods One hundred and four cognitively unimpaired individuals were divided into a high pathology load (33 individuals; HP) group and a low pathology (71 individuals; LP) one. …”
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The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib by Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan

“…These genes were predominantly associated with pathways such as axon guidance, microRNAs in cancer, and the JAK-STAT signaling pathway, among others. …”
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