Comprehensive pan-cancer analysis reveals NTN1 as an immune infiltrate risk factor and its potential prognostic value in SKCM by Fuxiang Luan, Yuying Cui, Ruizhe Huang, Zhuojie Yang, Shishi Qiao

“…Abstract Netrin-1 (NTN1) is a laminin-related secreted protein involved in axon guidance and cell migration. Previous research has established a significant connection between NTN1 and nervous system development. …”
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Multifaceted roles of ninjurin1 in immunity, cell death, and disease by Lili Zhu, Yunfei Xu, Yunfei Xu

“…Ninjurin1 (NINJ1) is initially identified as a nerve injury-induced adhesion molecule that facilitates axon growth. It is initially characterized to promote nerve regeneration and mediate the transendothelial transport of monocytes/macrophages associated with neuroinflammation. …”
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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease by Emma V. Jones, David S. Bouvier

“…These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. …”
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The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis by Khalil S. Rawji, V. Wee Yong

“…Many studies, however, have also reported beneficial roles of macrophages/microglia, including axon regenerative roles, assistance in promoting remyelination, clearance of inhibitory myelin debris, and the release of neurotrophic factors. …”
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Case report: Guillain-Barré syndrome and possible association with Lyme disease by I. Muliuolis, E. Tilindytė, R. Samaitienė

“… Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating or axon-damaging polyneuropathy. It is characterized by sensory, motor and reflex disorder, damaged cranial nerves, autonomic disorders, and, less frequently, damage to the central nervous system. …”
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Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells by Junhao Deng, Yiling Zhang, Yong Xie, Licheng Zhang, Peifu Tang

“…Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well. …”
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Differentially Expressed microRNAs in Peritoneal Dialysis Effluent-Derived Exosomes from the Patients with Ultrafiltration Failure by Weifei Wu, Xu Wu, Zhiqun Cheng, Zhenzhen Yang, Minhui Lu, Jing Cheng

“…Functional analyses revealed that these DE-miRNAs were significantly enriched in pathways of cancer, ubiquitin-mediated proteolysis, axon orientation, and the Rap1 and Ras signaling pathways. …”
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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…The result is a loss of neuronal homeostasis and progressive die-back of motor axons culminating in death of the afflicted motor neurons. …”
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Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides by Na Qiang, Shuo Tang, Xiang Liao, Hao Liang, Fang Xie, Ji-xiang Zhu

“…The small peptide was beneficial to the axon growth of PC12 cells.…”
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Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies by Alexandra D. Medyanik, Polina E. Anisimova, Angelina O. Kustova, Victor S. Tarabykin, Elena V. Kondakova

“…Although channelopathies indeed make up a significant proportion of DEE cases, many other mechanisms have been identified: impaired neurogenesis, metabolic disorders, disruption of dendrite and axon growth, maintenance and synapse formation abnormalities —synaptopathies. …”
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Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice by Olga Astakhova, Anna Ivanova, Ilia Komoltsev, Natalia Gulyaeva, Grigori Enikolopov, Alexander Lazutkin

“…These findings suggest that subcortical structures, particularly the striatum and optic tract, may possess a potential for self-repair through neuronal regeneration and axon remyelination.…”
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Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism by L. Di Cesare Mannelli, G. D'Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano

“…Moreover, osmicated preparations revealed a decrease in axon diameter and myelin thickness. Repeated treatments with PEA reduced the presence of oedema and macrophage infiltrate, and a significant higher myelin sheath, axonal diameter, and a number of fibers were observable. …”
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Autonomic Testing in Functional Gastrointestinal Disorders: Implications of Reproducible Gastrointestinal Complaints during Tilt Table Testing by Shaista Safder, Thomas C. Chelimsky, Mary Ann O'Riordan, Gisela Chelimsky

“…We compared results of TTT, Valsalva maneuver, deep breathing and the axon reflex sweat test. Overall treatment response and that specific to fludrocortisone was ranked from 1 to 5, with 1 “much worse,” 3 “neutral,” and 5 “much better.” …”
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A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke by Zhijian Zheng, Xiaohui Lin, Zijun Zhao, Qiang Lin, Ji Liu, Manli Chen, Wenwen Wu, Zhiyun Wu, Nan Liu, Hongbin Chen

“…It also helped maintain mitochondrial integrity and axonal morphology, greatly improving rat motor function and angiogenesis. …”
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The Effectiveness of Ebselen in Facial Nerve Crush Injury: An Experimental Study by Lütfü Şeneldir, Veysel Alparslan Gölcük, Gökçe Tanyeri Toker, Ayşegül Verim, Pembegül Güneş

“…These groups also showed similar features in terms of histopathological parameters such as axonal degeneration, vascular congestion, axon diameter, and myelin thickness. …”
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Longitudinal investigation of neurobiological changes across pregnancy by Yanbin Niu, Benjamin N. Conrad, M. Catalina Camacho, Sanjana Ravi, Hannah A. Piersiak, Lauren G. Bailes, Whitney Barnett, Mary Kate Manhard, David A. Cole, Ellen Wright Clayton, Sarah S. Osmundson, Seth A. Smith, Autumn Kujawa, Kathryn L. Humphreys

“…Here we observe a reduction in gray matter volume and an increase in neurite density index (NDI), a proxy of axon density, in white matter tracts across pregnancy. …”
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Decoding cortical folding patterns in marmosets using machine learning and large language model by Yue Wu, Xuesong Gao, Zhengliang Liu, Pengcheng Wang, Zihao Wu, Yiwei Li, Tuo Zhang, Tianming Liu, Tao Liu, Xiao Li

“…Further, gene enrichment analysis, neural migration analysis, and axon guidance pathway analysis were employed to elucidate the molecular mechanisms underlying these structural and functional differences. …”
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Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress by Chikako Sumi, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Yuki Okamoto, Yuki Asakawa, Kotaro Tanimoto

“…Expression of semaphorin 3A (Sema3A), which is an axon guidance molecule, has been confirmed in chondrocytes. …”
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Alterations of Dopamine-Related Transcripts in A11 Diencephalospinal Pathways after Spinal Cord Injury by Shunyi Zhao, Jaclyn H. DeFinis, Shaoping Hou

“…However, dopamine-β-hydroxylase (DBH), D1 receptors, and DA-associated transcription factors did not change following SCI. Furthermore, axon degeneration below the lesion substantially reduced mRNA levels of TH and D2 in the L1 spinal segment. …”
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Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model by Musaad A. Alshammari, Mohammad R. Khan, Fawaz Alasmari, Abdulaziz O. Alshehri, Rizwan Ali, Mohamed Boudjelal, Khalid A. Alhosaini, Abdurahman A. Niazy, Tahani K. Alshammari

“…The axon initial segment (AIS), the site of action potential initiation in neurons, is a critical determinant of neuronal excitability. …”
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