Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences by Joan Y Song, Roman Fleysher, Kenny Ye, Mimi Kim, Molly E Zimmerman, Richard B Lipton, Michael L Lipton

“…Conclusion: The inverse association of slope magnitude with age indicates loss of the sharp GWI transition in aging, which is consistent with processes such as dendritic pruning, axonal degeneration, and inflammation. This method overcomes techniques issues related to interrogating the GWI. …”
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Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism by Kelley C. Larson, Frederick W. Gergits, Abigail J. Renoux, Elizabeth J. Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G. McLaren, Berkley A. Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Mirescu

“…Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP). …”
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Sex-based differences in the long-term fate of hippocampal neurons born after a traumatic brain injury by Hannah C. Downing, Hannah C. Downing, Ashley B. Glover, Jessica E. Gebhardt, Jessica E. Gebhardt, Katherine L. Thompson, Kathryn E. Saatman, Kathryn E. Saatman, Kathryn E. Saatman

“…Neurons born after injury extended axons which formed synaptic terminals within the CA3 region. …”
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Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the... by Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo

“…Furthermore, our in vivo experiments demonstrated that Shh activation significantly reduced axonal degeneration, demyelination, and improved nerve conduction. …”
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