Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations by Jennifer N. Wu, Marc A. Dall'Era

“…Prostate cancer is now the most commonly diagnosed solid tumor in American men, due in part to widespread screening and aggressive diagnostic practices. Prostate cancer autopsy studies show the uniquely high prevalence rates of small, indolent tumors in men dying of other causes. …”
Get full text

Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions by Romana Tomaszewska, Krzysztof Okoń, Krystyna Nowak, Jerzy Stachura

“…The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. …”
Get full text

PULMONARY EMBOLISM IN THE PRACTICE OF AN OBSTETRICIAN-GYNECOLOGIST (CLINICAL CASE) by Елена Владимировна Рудаева, Юлия Валерьевна Васютинская, Любовь Борисовна Николаева, Светлана Ивановна Елгина, Кира Борисовна Мозес

“…Diagnosis of PE is very difficult and is not diagnosed at all in 50-80% of cases. At autopsy, it is important not only to diagnose PE but also to establish its source. …”
Get full text

Fatal Haemorrhagic Stroke Due to Concomitant Abuse of Sildenafil and Alcohol: A Case Report by Jithin Laxminarayana V, Azmath Tabassum, Kapil D, Nagamohan Rao B V, Kattamreddy Ananth Rupesh

“…We present the case of a 39-year-old male with no significant medical history who suffered a fatal stroke after consuming high doses of sildenafil while intoxicated with alcohol. Notable findings at autopsy include left ventricular hypertrophy, left capsuloganglioninc bleed and atherosclerotic changes in the coronary arteries. …”
Get full text

Lymphomatoid granulomatosis. Case Presentation by Marisela García de la Torre, Yanelka Bouza Jiménez, Stephany Milagros Acosta País, Maribel Misa Menéndez

“…On January 15, the clinical condition of the patient worsened with high fever, disorientation, marked excitement, awareness and respiratory insufficiency, and he died on the 16th. Autopsy revealed lymphomatoid granulomatosis as the main cause of death.…”
Get full text

Animal Models of Diabetic Retinopathy: Summary and Comparison by Angela Ka Wai Lai, Amy C. Y. Lo

“…Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. …”
Get full text

Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia—A Case Report and Review of the Literature by Sameera A. Alsafwani, Abdulwahed Al-Saeed, Rehab Bukhamsin

“…Bone marrow necrosis (BMN) is a rare clinical entity that was first described in an autopsy of a sickle cell disease (SCD) patient and is defined as ill-defined necrotic cells in an amorphous eosinophilic background with preservation of cortical bone. …”
Get full text

Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer by Hava Izci, Gitte Zels, Anirudh Pabba, Marion Maetens, François Richard, Maxim De Schepper, Josephine Van Cauwenberge, Ha-Linh Nguyen, Kristien Borremans, Sophia Leduc, Karen Van Baelen, Sigrid Hatse, Tatjana Geukens, Amena Mahdami, Hans Wildiers, Patrick Neven, Wouter Van Den Bogaert, Giuseppe Floris, Christine Desmedt

“…A trend towards smaller adipocytes in mammary fat at autopsy versus diagnosis was observed, suggesting potential age and/or treatment effects. …”
Get full text

JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinica... by Mohamed-Ali Babi, William Pendlebury, Steven Braff, Waqar Waheed

“…The patient passed away 3 months from the onset of her neurological symptoms. Autopsy confirmed the diagnosis of PML with presence of JC-polyoma virus by immunohistochemical staining. …”
Get full text

Suicide in New Zealand by Said Shahtahmasebi

“…A straightforward contextual analysis of this information suggests that (i) only five cases had contact with mental health services, in two of the cases this was due to a previous suicide attempt and in the other three it was due to drug and alcohol dependency; (ii) mental illness as the cause of suicide is fixed in the public mindset, (iii) this in turn makes psychological autopsy type studies that seek information from families and friends questionable; (iv) proportionally more females attempt, but more men tend to complete suicide; and (v) not only is the mental health-suicide relationship tenuous, but suicide also appears to be a process outcome. …”
Get full text

Fetal sirenomelia type VI. A case report by Lilian Rachel Vila Ferrán, María Antonia Ocaña Gil

“…Gustavo Aldereguía Lima General University Hospital in Cienfuegos, where a clinical autopsy was performed on the product of conception, diagnosing type VI sirenomelia with a single femur and tibia, absence of feet, agenesis of internal and external genitalia, bladder, ureters, urethra and anus and fusion of the sacrum to the iliac bones, a single umbilical artery and rectal atresia. …”
Get full text

Gas-Forming Pyogenic Liver Abscess with Septic Shock by Muhammad S. Khan, Muhammad K. Ishaq, Kellie R. Jones

“…The very rapid clinical course makes it difficult to diagnose on time, and most cases are diagnosed at autopsy. Therefore it is important to consider C. perfringens infection in any severely ill patient with fever and evidence of hemolysis. …”
Get full text

Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy by Ensi Voshtina, Huiya Huang, Renju Raj, Ehab Atallah

“…The patient ultimately expired, and autopsy of the brain revealed granulomatous amebic encephalitis due to opportunistic infection by Acanthamoeba species. …”
Get full text

Dengue Viral Myositis Complicated with Rhabdomyolysis and Superinfection of Methicillin-Resistant Staphylococcus aureus by Vinothan Sunderalingam, Thirumavalavan Kanapathipillai, P. A. S. Edirisinghe, K. M. M. P. Dassanayake, I. H. G. S. Premawansa

“…Despite intensive care management, he died due to multiorgan failure. Autopsy and serological studies confirmed the diagnosis. …”
Get full text

Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature by Hussein Algahtani, Ahmad Subahi, Bader Shirah

“…In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.…”
Get full text

Rare but Not so Rare? The Evolving Spectrum of Whipple's Disease by John M Conly, B Lynn Johnston

“…He reported the case of a 36-year-old physician with "a gradual loss of weight and strength, stools consisting chiefly of neutral fat and fatty acids, indefinite abdominal signs, and a peculiar multiple arthritis" (1). Findings at autopsy consisted of poly-serositis, aortic valve vegetations and deposition of fat in the intestinal mucosa and regional lymph nodes with marked infiltration by foamy macrophages (1). …”
Get full text

Chronic active lesions in multiple sclerosis: classification, terminology, and clinical significance by Assunta Dal-Bianco, Jiwon Oh, Pascal Sati, Martina Absinta

“…Initially characterized in autopsy specimens, multiple approaches to visualize chronic active lesions (CALs) in vivo using advanced neuroimaging techniques and postprocessing methods are rapidly emerging. …”
Get full text

The Extent of Lymphadenectomy at the Time of Radical Cystectomy for Bladder Cancer and its Impact on Prognosis and Survival by David Y. Josephson, John P. Stein

“…The boundaries and technique of an extended lymphadenectomy are also highlighted. Autopsy and contemporary survival data are presented to suggest that a more extensive lymphadenectomy has both prognostic and therapeutic utility. …”
Get full text

Sociodemographic factors of violent deaths related to licit or ilicit psychoactive substances: a cross-sectional study, Ceará, Brazil, 2015-2019 by Wanderley Pinheiro de Holanda Júnior, Raimunda Hermelinda Maia Maceno, Maria Augusta Drago Ferreira

“…Methods Cross-sectional study based on autopsy data and toxicology tests on victims of cases registered by the Ceará Forensic Expert service, from 2015 to 2019. …”
Get full text

Left Ventricle Outflow Obstruction by Reverse-Oriented Tricuspid Semilunar Valve-Like Endocardial Duplicatures by Kristína Mikuš-Kuracinová, Pavel Babál, Eliška Kubíková

“…She died with signs of heart failure with pulmonary edema development. At autopsy, there was left ventricle hypertrophy (wall thickness: 21 mm). …”
Get full text