TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease by Yunxia Du, Ming Wu, Shan Song, Yawei Bian, Yonghong Shi

Subjects: “…Autophagy…”
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Lipopolysaccharide inhibits osteoblast formation and receptor activator of nuclear factor-κB ligand degradation via autophagy inhibition by Huaizhi Zhang, Jianhua Lin, Xu Chen, Jianhui Dai, Haibin Lin

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Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice by Wenbin Zheng, Jing Zhou, Shasha Song, Wen Kong, Wenfang Xia, Lulu Chen, Tianshu Zeng

“…This study was aimed at investigating the effect of sitagliptin on hepatic steatosis, insulin resistance, inflammation, and autophagy and exploring the underlying molecular mechanism. …”
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FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage by Fan Wang, Yue Xu, Yajie Wang, Qian Liu, Yanan Li, Weiwei Zhang, Huiming Nong, Junhong Zhang, Hao Zhao, Huaqian Yang, Lingchuan Guo, Jianfeng Li, Jianfeng Li, Hong Li, Qianqian Yang

“…IntroductionCochlear spiral ganglion neurons (SGNs) could be damaged by ototoxic drug, cisplatin (Cis), during which process autophagy was involved. FAM134B, the first detected endoplasmic reticulum autophagy (ER-phagy) receptor, plays an important part in the dynamic remodelling of the ER, the mutation of which affects sensory and autonomic neurons. …”
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TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling Pathway by Lu Shi, Yijun Tu, Yu Xia, Siqi Ye, Chaozhi Ma, Yanwen Liu, Pengtao You

“…Autophagy-associated proteins were examined by Western blot analysis. …”
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Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γ Functional Module of Autophagy in Rheumatoid Arthritis by Weiyan Wang, Chunling Li, Zhiyi Zhang, Yue Zhang

“…Dysregulated autophagy leads to autoimmune diseases including rheumatoid arthritis (RA). …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Furthermore, the results show that activation of 5′AMP-activated protein kinase (AMPK) by metformin enhances cell autophagy in senescent hBMSCs. These findings suggest that metformin exerts antiaging function within the low concentration range by enhancing autophagy and exhibits potential benefits for clinical stem cell therapy by ameliorating the ex vivo replicative senescence of hBMSCs.…”
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Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma by Chaoqun Zhang, Dianxing Sun, Huifang Zhou, Chao Liu, Jie Ruan, Jiwen Kang, Ying Xie

Subjects: “…Autophagy…”
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RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose by Chenlin Gao, Jiao Chen, Fang Fan, Yang Long, Shi Tang, Chunxia Jiang, Jiying Wang, Youhua Xu, Yong Xu

“…In this study, we aimed to explore the mechanisms mediated by RIPK2 in autophagy and the relationship with ROS-NLRP3 of DN, by investigating the levels of RIPK2 and autophagy in glomerular mesangial cells (GMCs) stimulated with high glucose. …”
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Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy by Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu

Subjects: “…Autophagy…”
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Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats by Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying

“…The expression changes of pulmonary fibrosis and autophagy marker proteins are attenuated by QFTL. Furthermore, the autophagy inhibitor CQ significantly reversed the downward trend in HYP levels and α-SMA protein expression, which QFTL improved in BLM-induced pulmonary fibrosis rats. …”
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Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

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Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins by Malihe Soltani, Majid Rahmati, Mohammad Reza Nikravesh, Shahin Saeedi Nejat, Mahdi Jalali

“…Autophagy is influenced by oxidative stress, disturbances of calcium homeostasis, and hyperthermia conditions. …”
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Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model by Jie Gao, Feng Min, Shasha Wang, Heng Lv, Huan Liang, Ben Cai, Xianjie Jia, Qin Gao, Ying Yu

“…This study investigated the mechanism of Rho-kinase-mediated autophagy in RIC. Methods. Sixty male Sprague–Dawley rats were randomly divided into six groups: sham, I/R, RIC, I/R+fasudil, RIC+wortmannin, and RIC+fasudil+wortmannin. …”
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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing by Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu

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Identification of an Autophagy-Related Signature Based on Whole Bone Marrow Sequencing for the Prognosis and Immune Microenvironment Characterization of Multiple Myeloma by Licheng Li, Ting Chen, Jishi Wang, Mengxing Li, Qinshan Li

“…Therefore, the purpose of the present research was to identify potential autophagy-related genes (ARGs) in patients with MM. …”
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The Protective Effect of Naringenin on Airway Remodeling after Mycoplasma Pneumoniae Infection by Inhibiting Autophagy-Mediated Lung Inflammation and Fibrosis by Yan Lin, Dan Tan, Qianna Kan, Zhen Xiao, Zhiyan Jiang

“…These results indicate that NRG treatment suppressed the inflammatory response and pulmonary fibrosis by inhibition of autophagy after MP infection.…”
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Autophagy activation alleviates annulus fibrosus degeneration via the miR-2355-5p/mTOR pathway by Zilin Yu, Chunyang Fan, Yubo Mao, Xiexing Wu, Haiqing Mao

“…GEO analysis revealed significant alterations in miR-2355-5p expression, confirming its role in regulating the mTOR pathway and autophagy. Conclusions Autophagy, mediated by the miR-2355-5p/mTOR pathway, plays a protective role in AFCs degeneration. …”
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The Anticancer Activity of Lycium barbarum Polysaccharide by Inhibiting Autophagy in Human Skin Squamous Cell Carcinoma Cells In Vitro and In Vivo by Meihua Zeng, Qingtao Kong, Fang Liu, Jun Chen, Hong Sang

“…LBP can induce apoptosis of A431 cells by inhibiting autophagy and can inhibit tumor growth in vivo.…”
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Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway by Liwei Wu, Qinghui Zhang, Weiqi Dai, Sainan Li, Jiao Feng, Jingjing Li, Tong Liu, Shizan Xu, Wenwen Wang, Xiya Lu, Qiang Yu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Xiaoming Fan, Chuanyong Guo

“…Compared with the IR group, the treatment of QE reduced the release of cytokines, leading to inhibition of apoptosis and autophagy via downregulation of the ERK/NF-κB pathway in this model of hepatic IR injury. …”
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