Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population by Hatice Gül Dursun, Hüseyin Osman Yılmaz, Recep Dursun, Sevsen Kulaksızoğlu

“…Cytotoxic T lymphocyte antigen-4 (CTLA-4) expressed only on activated T cells is an immunoregulatory molecule and plays a role in the pathogenesis of autoimmune disorders. We aimed to determine whether CTLA-4 gene polymorphisms are associated with development and/or clinical features of psoriasis vulgaris (Pv). …”
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Genetic Selection Pressure on TLR9 Gene Increases Individual Susceptibility to Systemic Inflammatory Disease: A Case Study of Kano State Population by Yusuf Jibril Habib, Mohammed Sani Jaafaru

“…Systemic lupus erythematosus (SLE) and other autoimmune disorders have been linked to this genetic plasticity. …”
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Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…These agents can precipitate autoimmune disorders. As the use of anti-PD-1 agents is expected to rise, physicians should be educated about the potential side effects. …”
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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

“…Hence, IL-2 is now emerging as a target for novel therapeutic approaches in several autoimmune disorders. This study was carried out to set up an effective virtual screening (VS) pipeline for IL-2. …”
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Hemophagocytic Lymphohistiocytosis Complicating Dengue and Plasmodium vivax Coinfection by Muhammad Khurram, Muhammad Faheem, Muhammad Umar, Asif Yasin, Wajeeha Qayyum, Amna Ashraf, Javeria Zahid Khan, Ali Hasnain Yasir, Yusra Ansari, Muhammad Asad, Iram Khan, Shuja Abbas, Irum Rasheed, Natasha Rasool, Hamama Tul Bushra Khar

“…Infections, malignancies, and autoimmune disorders are associated with development of HLH. …”
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Recurrence of Thrombotic Thrombocytopenic Purpura after mRNA-1273 COVID-19 Vaccine Administered Shortly after COVID-19 by Korin Karabulut, Ana Andronikashvili, Ahmet Hakki Kapici

“…Most of the cases are the result of acquired deficiency of ADAMTS13, for which the exact etiology is unknown but reported to be related to various autoimmune disorders, infections, and medications. Our case report features of a patient with a history of idiopathic thrombocytopenic purpura and thrombotic thrombocytopenic purpura, who developed a recurrence of TTP 5 days after his first dose of the mRNA Coronavirus disease 2019 (COVID-19) vaccine (mRNA-1273 vaccine) in the setting of recent COVID-19. …”
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Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery by Francesco Maione, Antonio Parisi, Elisabetta Caiazzo, Silvana Morello, Fulvio D'Acquisto, Nicola Mascolo, Carla Cicala

“…Interleukin-17A (IL-17A), the most widely studied member of the IL-17 cytokine family, is a cytokine which emerged to be critical for host defense as well as in the pathogenesis of autoimmune disorders. Moreover, IL-17A is involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and acute coronary syndrome and in the cardiovascular risk associated with systemic immunological disorders. …”
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Hemophagocytic Lymphohistiocytosis in a Patient with Classical Hodgkin Lymphoma by G. Hyun, K. J. Robbins, N. Wilgus, L. Grosso, S. D. Goyal

“…Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome that can be associated with inherited genetic mutations, malignancy, autoimmune disorders, and viral infections. Though the pathogenesis is not fully known, HLH is understood to be a reactive process in the setting of uncontrolled activation of macrophages, CD8+ cytotoxic lymphocytes, and other immune cells. …”
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Endocervical miRNA-142 expression in patients with pelvic inflammatory disease positive for Chlamydia trachomatis by Aliaa Zara Allah Hussein Al-Tememy, Maysaa S. Alshukri, Asmaa Kadhim Gatea

“…Changes in miRNA expression have been identified in many diseases, such as cardiac and autoimmune disorders, schizophrenia, and cancer. In this cross-sectional pilot investigation, samples were taken from control women who were not infected and from symptomatic women who were infected with C. trachomatis. …”
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Candidate antirheumatic genotherapeutic plasmid constructions have low immunogenicity by T. S. Nepomnyashchikh, T. V. Tregubchak, S. N. Yakubitskiy, O. S. Taranov, R. A. Maksyutov, S. N. Shchelkunov

“…The patients treated with TNF inhibitors are more susceptible to infection diseases, they are also at higher risk of developing neoplastic or autoimmune disorders. Biotherapeutics become less effective or even lose their efficiency with evoking specific antidrug antibodies. …”
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Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages by Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Ning Wang, Junying Ding, Qingquan Liu

“…Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. …”
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DIABETES MELLITUS IN PATIENTS WITH LIVER CIRRHOSIS: NEW TREATMENT OPTIONS by L. Yu. Morgunov

“…There are common mechanisms that provoke metabolic and autoimmune disorders in the development of chronic hepatitis and cirrhosis, leading to steatosis, insulin resistance, impaired glucose tolerance and the development of diabetes mellitus. …”
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Prevalence of Thyroid Dysfunction and Antithyroid Antibodies in North India by Cherry Bansal, Amanpreet Singh, Pragya Pandey

“…Incidence of thyroid dysfunction – hypothyroidism, hyperthyroidism, and autoimmune disorders are on the rise. There are minimal data reports regarding thyroid disorders prevalence in North India. …”
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Autoimmune and Neoplastic Thyroid Diseases Associated with Hepatitis C Chronic Infection by Poupak Fallahi, Silvia Martina Ferrari, Ugo Politti, Dilia Giuggioli, Clodoveo Ferri, Alessandro Antonelli

“…In patients with “HCV-associated mixed cryoglobulinemia” (MC + HCV), a higher prevalence of thyroid autoimmune disorders was shown not only compared to controls, but also versus HCV patients without cryoglobulinemia. …”
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Characterization of novel human endogenous retrovirus structures on chromosomes 6 and 7 by Nicholas Pasternack, Nicholas Pasternack, Ole Paulsen, Avindra Nath

“…We examined a cohort of 222 individuals for HML-2 proviruses 6q14.1 and 7p22.1a, two loci that are capable of producing full-length viral proteins and have been previously implicated in several cancers, autoimmune disorders and neurodegenerative diseases, using long-read DNA sequencing. …”
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RNAI-MEDIATED SILENCING OF MATRIX METALLOPROTEINASE 1 IN EPIDERMAL KERATINOCYTES INFLUENCES THE BIOLOGICAL EFFECTS OF INTERLEUKIN 17A by J. A. Mogulevtseva, A. V. Mezentsev, S. A. Bruskin

“…Matrix metalloproteinases (MMPs) are important for the pathogenesis of psoriasis and other autoimmune disorders. In the extracellular matrix, accumulation of proinflammatory cytokines, such as interleukin 17A (IL-17A), leads to induction of several MMPs, including MMP1. …”
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A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…Dysregulation of both IL-1β and its related pathways is involved in inflammatory/autoimmune disorders and in a wide range of other diseases. …”
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Neuromyelitis optica spectrum disorder: epidemiology, pathogenesis, diagnosis, treatment, and prognosis by J. Čemerkaitė, I. Kaukėnaitė, R. Liutkevičienė

“…Factors leading to a worse prognosis include the severity of the first attack, higher number of relapses in the first two years, older age at the disease onset, and association with other autoimmune disorders. The overall 10-year mortality after diagnosis is 20-25%. …”
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Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D by Konstantinos Toulis, Xanthippi Tsekmekidou, Evangelos Potolidis, Triantafyllos Didangelos, Anna Gotzamani-Psarrakou, Pantelis Zebekakis, Michael Daniilidis, John Yovos, Kalliopi Kotsa

“…Vitamin D deficiency has been associated with both type 2 diabetes mellitus (T2DM) and autoimmune disorders. The association of vitamin D with T2DM and thyroid autoimmunity (TAI) has not been investigated. …”
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sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity by Xinxin Chen, Qingyao Wang, Xiangguo Cong, Shuyi Jiang, Shuxiang Li, Qiong Shen, Lei Chen

“…Background. Autoimmune disorders are associated with gestational diabetes mellitus (GDM) in pregnant women who were positive for thyroid peroxidase antibody (TPOAb). …”
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