A New ELISA for Dermatomyositis Autoantibodies: Rapid Introduction of Autoantigen cDNA to Recombinant Assays for Autoantibody Measurement by Yoshinao Muro, Kazumitsu Sugiura, Masashi Akiyama

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Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection by Ankit Bharat, T. Mohanakumar

“…Preexisting and de novo immune responses to tissue-restricted SAgs (i.e., autoimmunity) play a major role in rejection. In this review, we discuss the evidence that supports autoimmunity as a contributor to rejection. …”
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Increased interferon I signaling, DNA damage response and evidence of T-cell exhaustion in a patient with combined interferonopathy (Aicardi-Goutières Syndrome, AGS) and cohesinopa... by Sorina Boiu, Nikolaos Paschalidis, George Sentis, Theodora Manolakou, Andrianos Nezos, Manolis Gialitakis, Maria Grigoriou, Erato Atsali, Melpomeni Giorgi, Argirios Ntinopoulos, Clio Mavragani, Periklis Makrythanasis, Dimitrios T. Boumpas, Aggelos Banos

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Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond by Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos

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Evaluating the use of Uromune® autovaccine in recurrent urinary tract infections: a pilot unicenter retrospective study in Reus, Spain by Simona Iftimie, Paula Ladero-Palacio, Ana F. López-Azcona, Laia Pujol-Galarza, Antoni Pont-Salvadó, Xavier Gabaldó-Barrios, Jorge Joven, Jordi Camps, Antoni Castro, Mercè Pascual-Queralt

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Immune Thrombocytopenia and JAK2V617F Positive Essential Thrombocythemia: Literature Review and Case Report by M. A. Sobas, T. Wróbel, K. Zduniak, M. Podolak-Dawidziak, J. Rybka, M. Biedroń, M. Sawicki, J. Dybko, K. Kuliczkowski

“…On the basis of this case history a possible role of autoimmunity as a predisposing factor to myeloproliferation has been discussed.…”
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Transient Antiphospholipid Syndrome Associated with Primary Cytomegalovirus Infection: A Case Report and Literature Review by Tsuyoshi Nakayama, Mitsuteru Akahoshi, Kensuke Irino, Yasutaka Kimoto, Yojiro Arinobu, Hiroaki Niiro, Hiroshi Tsukamoto, Takahiko Horiuchi, Koichi Akashi

“…Viral infection is known to induce transient autoimmunity in humans. Acute cytomegalovirus (CMV) infection is implicated in occasional thrombosis formation. …”
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Characterization of Autoantibodies against the E1𝜶 Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis by Tsutomu Mori, Hiromasa Ohira, Masahito Kuroda, Masaki Kato, Yoshiki Yamaguchi, Hideo Kochi

“…Since anti-E1 antibodies always appear in combination with anti-E2 antibodies, the mechanisms underlying the autoimmunity against E1 may be linked to, but distinct from, those against E2. …”
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Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients by Yiliang Meng, Kai Cai, Jingjie Zhao, Keyu Huang, Xiumei Ma, Jian Song, Yunguang Liu

“…It is noteworthy that six subpopulations were identified in ccRCC biopsy, and two were more relevant to autoimmunity, while the other four are more relevant to the tumor pathology. …”
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Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection by Yan Wang, Xiaodong Gu, Jianbin Xiang, Zongyou Chen

“…MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. …”
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Cancer Immunology and Cancer Immunodiagnosis 2016 by Jianying Zhang, Bin Zhang, Yi Zhang

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Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis by Jun-Qi Yang, Yonghua Zhou, Ram Raj Singh

“…We have revealed the regulatory effect of iNKT cells on autoimmunity with a serial of publications. On the other hand, the role of iNKT cells in parasitic infections, especially in recently attractive topic “hygiene hypothesis,” has not been clearly defined yet. …”
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Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives by Chenchen Shi, Haipeng Li, Yifu Yang, Lifei Hou

“…In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions.…”
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Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes by Yi Chen, Wen Zhang, JingSi Chen, Ningjian Wang, Chi Chen, Yuying Wang, Heng Wan, Bo Chen, Yingli Lu

“…We aimed to evaluate the relationship of phthalate metabolites with thyroid function and thyroid homeostasis parameters in type 2 diabetes and to explore whether thyroid autoimmunity status and metformin, the most common antidiabetic drug, may influence such associations. …”
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Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants by Yamen Homsi, John Andrew Carlson, Samer Homsi

“…More robust research is needed to understand the connection between silicone breast implants and autoimmunity.…”
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Collagen XVII: A Shared Antigen in Neurodermatological Interactions? by Allan Seppänen

“…In addition, collagen XVII has been found to be present in the central nervous system, thus offering an explanation for the statistical association between bullous pemphigoid, in which autoimmunity is directed against dermal collagen XVII, and neurological diseases. …”
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Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value by Yuanyuan Shao, Xiaofeng Pan, Rong Fu

“…In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in inflammatory responses, autoimmunity, and infectious diseases. In this review, we will summarize the function of T cell-derived exosomes and their therapeutic potential.…”
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Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases by Jiani Li, Jichao Sha, Liwei Sun, Dongdong Zhu, Cuida Meng

“…Regulatory T (Treg) cells are a subtype of CD4+ T cells that play a significant role in the protection from autoimmunity and the maintenance of immune tolerance via immune regulation. …”
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Hemophagocytic Lymphohistiocytosis in an AIDS Patient with Kaposi Sarcoma: A Treatment Dilemma by Oluwadunni E. Emiloju, Sorab Gupta, Vivian Arguello-Guerra, Claudia Dourado

“…Genetic causes are responsible for primary hemophagocytosis, but malignancies, infections, and autoimmunity underlie most of the secondary cases. We present an unusual case of a patient with AIDS and disseminated Kaposi sarcoma who was commenced on highly active antiretroviral therapy (HAART) but developed HLH secondary to immune reconstitution inflammatory syndrome (IRIS). …”
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When the Benign Pneumatosis Intestinalis Becomes No Longer Benign: A Rare Case of Bowel Perforation in a Patient with Systemic Sclerosis by Jian Guan, Alvina Munaf, Alric V. Simmonds, Irteza Inayat

“…Systemic sclerosis is a multisystem disease featured with autoimmunity and organ fibrosis. Although gastrointestinal (GI) tract involvement is common in patients with systemic sclerosis, colonic perforation is extremely rare. …”
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