Diagnostic delay of myositis: protocol for an integrated systematic review by Christine Phillips, Matthew Cook, Anne Parkinson, Jane Desborough, Tergel Namsrai, Anita Chalmers, Christine Lowe

“…Introduction Idiopathic inflammatory myopathies (IIM). described as ‘inflammatory myositis’, are a heterogeneous group of rare muscular autoimmune diseases characterised by skeletal muscle inflammation. …”
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Immunological Aspects of Fulminant Type 1 Diabetes in Chinese by Zhen Wang, Ying Zheng, Yiting Tu, Zhijie Dai, Jian Lin, Zhiguang Zhou

“…We also detected a significant increase for IFN-γ expression in FT1D PBMCs as compared with that of healthy controls. Conclusion. Autoimmune responses might be involved in the pathogenesis of Chinese FT1D.…”
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Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus by Paola del Carmen Guerra-de Blas, Yael Sebastián Villaseñor-Talavera, Daniela de Jesús Cruz-González, Lourdes Baranda, Lesly Doníz-Padilla, Carlos Abud-Mendoza, Roberto González-Amaro, Adriana Elizabeth Monsiváis-Urenda

“…ILT4 was shown not to have a crucial role in regulating the maturation and function of DC from healthy controls but is partially involved in the maturation process and immunogenic capability of DC from SLE patients, suggesting that other inhibitory receptors, involved in the regulation of DC tolerogenic function, may be impaired in this autoimmune disease.…”
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Butyric Acid Modulates Gut Microbiota to Alleviate Inflammation and Secondary Bone Loss in Ankylosing Spondylitis by Ke You, Lianjun Yang, Zhihai Su, Jun Shen, Xinyang Fan, Yuanqing Guo, Zhen Yuan, Hai Lu

“…<b>Background:</b> Ankylosing spondylitis (AS) is a chronic inflammatory and autoimmune disease that primarily affects the sacroiliac joints and axial skeleton. …”
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Feature selection enhances peptide binding predictions for TCR-specific interactions by Hamid Teimouri, Hamid Teimouri, Zahra S. Ghoreyshi, Zahra S. Ghoreyshi, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Jason T. George, Jason T. George, Jason T. George, Jason T. George

“…Accurate prediction of peptide binding to TCRs is essential for advancing immunotherapy, vaccine design, and understanding mechanisms of autoimmune disorders.MethodsThis study presents a theoretical approach that explores the impact of feature selection techniques on enhancing the predictive accuracy of peptide binding models tailored for specific TCRs. …”
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Resistance Exercise Reduces Skeletal Muscle Cachexia and Improves Muscle Function in Rheumatoid Arthritis by Salaheddin Sharif, James M. Thomas, David A. Donley, Diana L. Gilleland, Daniel E. Bonner, Jean L. McCrory, W. Guyton Hornsby, Hua Zhao, Mathew W. Lively, Jo Ann A. Hornsby, Stephen E. Alway

“…Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune, inflammatory disease associated with cachexia (reduced muscle and increased fat). …”
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Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions by Zygmunt Mackiewicz, Justyna Mażul, Ieva Narkevičiūtė, Irena Dumalakienė, Irena Butrimienė, Rita Vilienė, Indrė Stankevičienė, Diana Mieliauskaitė

“…The aim of this study was to evaluate the expression of persistence of mumps virus and some cells that interact with viral infection in the focus of the autoimmune epithelitis and peripheral blood of Sjögren’s syndrome patients in comparison to patients with rheumatoid arthritis (RA) and nonautoimmune sicca syndrome (nSS). …”
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Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model by Akiko Nishidate, Kana Takemoto, Yuki Imura, Mikako Murase, Ryu Yamanaka, Manami Kikuchi, Junpei Anan, Sayuka Kato, Airi Akatsuka, Sachiko Mochizuki, Yuzo Koda

“…Abstract Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders characterized by immune cell infiltration of muscle tissue accompanied by inflammation. …”
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Real-world clinical experience with secukinumab in psoriatic arthritis: an observational study and a literature review by Eleonora Celletti, Giulio Gualdi, Emanuela Sabatini, Francesco Cipollone, Fabio Lobefaro, Paolo Amerio

“…The major comorbidities recorded were fibromyalgia (33% of patients), recurrent bilateral anterior uveitis, and autoimmune thyroiditis with hypothyroidism (both 13% of the patients). …”
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Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice by Ying Huang, Haiying Hu, Ling Liu, Jing Ye, Zhen Wang, Bin Que, Wenjing Liu, Ying Shi, Tao Zeng, Lei Shi, Qingwei Ji, Chao Chang, Yingzhong Lin

“…Interleukin- (IL-) 35, a novel functional cytokine of regulatory T cells (Treg) comprised of the IL-12p35 subunit and the other subunit Epstein-Barr virus-induced gene 3 (EBI3), regulates the activity of CD4+ T cells and macrophages, thereby playing a critical role in inflammatory and autoimmune diseases. Previous studies demonstrated that both recombinant mice and human IL-35 attenuated atherosclerosis in ApoE-/- mice. …”
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Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis by Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang

“…In vitro and in vivo, the effects of NIK inhibitor (B022) on the function of CD19+B cells and CD4+T cells were detected under the MG PBMCs, sorted B cells and experimental autoimmune MG (EAMG) rat model, respectively. Results The expression levels of NIK were upregulated in CD19+B cells, CD4+T cells and serum from new-onset MG patients. …”
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Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study by Sakis Lambrianides, Christiana A. Demetriou, Andis Tillyris, Elena Kkolou, Eftychia Gaglia, Eleni Agkastinioti, Eleni Leonidou, Yiolanda-Panayiota Christou, Savvas S. Papacostas, Kleopas A. Kleopa, Theodoros Kyriakides, Marios Pantzaris

“…In recent years, a new subpopulation of patients at risk for PML has emerged, due to the growing use of immunomodulatory or immunosuppressive therapies in autoimmune diseases such as multiple sclerosis (MS). …”
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Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

“…Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disorders, cardiovascular problems, diabetes, neurological diseases, and cancers. …”
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Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. Studies have demonstrated that berberine exhibits polypharmacological effects, including antibacterial, anti-inflammatory, antioxidant, and hypoglycemic activities. …”
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Synovial Fluid Cell Proteomic Analysis Identifies Upregulation of Alpha-Taxilin Proteins in Rheumatoid Arthritis: A Potential Prognostic Marker by Ashish Sarkar, Shivani Sharma, Prachi Agnihotri, Tanmoy Sarkar, Pooja Kumari, Rajesh Malhotra, Barun Datta, Vijay Kumar, Sagarika Biswas

“…Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting the joints and surrounding tissue. …”
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Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients by Yuka Satoh, Hatsue Ogawara, Osamu Kawamura, Motoyasu Kusano, Hirokazu Murakami

“…In some cases, these changes may induce systemic autoimmune diseases.…”
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Anti‐retinal Autoantibodies in Hydroxychloroquine Eye Toxicity by Samuel D. Good, Grazyna Adamus, Michael B. Gorin, Jordan Jacquez, Jennifer Grossman, Isao Matsuura, Ashira Hasan, Brian Skaggs, Maureen McMahon

“…Objective Autoimmune retinopathy and hydroxychloroquine (HCQ)‐related retinal toxicity share many similarities, raising the possibility autoimmunity plays a role in HCQ retinopathy. …”
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Synergistic Effects of Extra X Chromosome on Development of Systemic Lupus Erythematosus and Sjögren Disease in Klinefelter and Triple X Syndrome: A Retrospective Cohort Study by Anna‐Kay Palmer, Irene J. Tan

“…Objective Systemic lupus erythematosus (SLE) and Sjögren disease (SjD) are autoimmune diseases with significant female predominance. …”
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Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination by Anurag Maheshwari, Kris Janssens, Jeroen Bogie, Chris Van Den Haute, Tom Struys, Ivo Lambrichts, Veerle Baekelandt, Piet Stinissen, Jerome J. A. Hendriks, Helena Slaets, Niels Hellings

“…Systemic IL-11 treatment was shown to ameliorate clinical symptoms in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. …”
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MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway by Pei Huang, Guangli Yang, Pingping Zhang, Yin Zhu, Yaning Guan, Jian Sun, Qian Li, Yang An, Xiaoqi Shi, Juanjuan Zhao, Chaohong Liu, Zhixu He, Yan Chen, Zuochen Du

“…In summary, this study reveals the diverse roles of MAPK4 in regulating of B cell functions, with potential implications for developing therapeutic strategies for RA and related autoimmune diseases.…”
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