Heat therapy in rheumatic and musculoskeletal diseases – an overview of clinical and molecular effects by Philipp Klemm, Nils Schulz, Priyanka Boettger, Uwe Lange

“…., inflammatory cytokines and the cellular autoimmune system), thus offering new explanations of clinical effects of physical therapy. …”
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Rheumatoid arthritis associated cytokines and therapeutics modulate immune checkpoint receptor expression on T cells by Dana Emerson, Eve Merriman, Pia P. Yachi

“…In addition, SOC RA therapeutics such as glucocorticoids and TNF inhibitors modulated IR and cytokine expression in the presence of RA synovial fluid.ConclusionsThis study points to an important and intricate relationship between cytokines and IRs in shaping immune responses in autoimmune pathology. The modulation of IR expression by RA-associated cytokines and SOC therapeutics provides new insights for the use of targeted treatments in managing RA pathology.…”
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The effect of acromegaly on thyroid disease by Caiyan Mo, Liyong Zhong

“…Whether patients with acromegaly have an increased risk of thyroid cancer remains controversial, and routine thyroid ultrasonography and regular cancer screening are recommended in such cases, especially when the nodules possess malignant propensity. TAO is an autoimmune disease and newer treatments are being discovered against it. …”
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Design and synthesis of amino-substituted N-arylpiperidinyl-based inhibitors of the (immuno)proteasome by Gobec Martina, Obreza Aleš, Jukič Marko, Baumgartner Ana, Mihelčič Nja, Potočnik Špela, Virant Julija, Mlinarič Irena, Stanislav Raščan, Sosič Gobec Izidor

“…The constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting different catalytically active subunits of both isoforms, is a viable approach against these diseases. …”
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Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome: A Case Report and Review of the Literature by B. Routy, T. Huynh, R. Fraser, C. Séguin

“…Catastrophic antiphospholipid syndrome (CAPS) is a rare autoimmune condition, which has been associated with a high mortality rate. …”
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Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 by Karen J. Juárez-Navarro, Eduardo Padilla-Camberos, Néstor Fabián Díaz, Ariel Miranda-Altamirano, N. Emmanuel Díaz-Martínez

“…Nowadays, there are more than a thousand registered clinical trials related to MSC application around the world, highlighting MSC role on difficult-to-treat high-incidence diseases such as the current COVID-19, HIV infections, and autoimmune and metabolic diseases. Here, we summarize a general overview of MSCs and their therapeutic mechanisms; also, we discuss some of the novel clinical trial protocols and their results as well as a comparison between the number of registries, countries, and search portals.…”
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The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver by Hiroyuki Nakashima, Bradley M. Kearney, Manabu Kinoshita

“…LXR activation, therefore, has great potential for clinical applications in the treatment of metabolic, infectious, and autoimmune diseases. In this review, we discuss the current understanding of the link between LXRs and innate immune cells in the liver, along with prospects for clinical applications of LXR agonists.…”
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Risk Factors for Neonatal Sepsis in Pregnant Women with Premature Rupture of the Membrane by Dwiana Ocviyanti, William Timotius Wahono

“…Samples with existing comorbidities such as diabetes mellitus or other serious systemic illnesses such as heart disease or autoimmune condition were excluded from the analysis. …”
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Prevalence of Splanchnic Vein Thrombosis in Pancreatitis: A Systematic Review and Meta-Analysis of Observational Studies by Wenda Xu, Xingshun Qi, Jiang Chen, Chunping Su, Xiaozhong Guo

“…According to the causes of pancreatitis, the pooled prevalence of SVT was 12.2% and 14.6% in patients with hereditary and autoimmune pancreatitis. According to the location of SVT, the pooled prevalence of portal vein, splenic vein, and mesenteric vein thrombosis was 6.2%, 11.2%, and 2.7% in pancreatitis. …”
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Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis by Weiqian Chen, Qin Wang, Yini Ke, Jin Lin

“…Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by the presence of autoantibodies against citrullinated protein antigens and proinflammatory cytokines which cause chronic synovitis, bone erosion, and eventual deformity; however, the precise etiology of RA is unclear. …”
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Reactive Hip Arthritis and Avascular Necrosis After Severe COVID-19 Infection: A Case Report and Comprehensive Review of Literature by Fatima Alkindi, Shamma Al Nokhatha, Khalid Alseiari, Khalid A. Alnaqb

“…Human leukocyte antigen-B27 was positive and synovial fluid culture, autoimmune workup, crystals, and infectious aetiologies were negative. …”
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Serum Analysis in Patients with Temporomandibular Disorders: A Controlled Cross-Sectional Study in Norway by Kordian Staniszewski, Henning Lygre, Trond Berge, Annika Rosén

“…Temporomandibular disorder (TMD) is characterized by pain and dysfunction in the temporomandibular join (TMJ) and the masticatory apparatus. Associations with autoimmune diseases, inflammatory conditions, and nutrition deficiencies have been reported in previous studies of TMD patients. …”
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ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation by Uroosa Ibrahim, Amina Saqib, Maryam Rehan, Jean Paul Atallah

“…Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis of HLH. …”
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Herbal remedies as a potential alternative therapy for arthritis by Disha Trivedi, Riya Jayapal Roja, Eva Künnemann

“…Arthritis forms a vicious cycle, where upon overuse of a joint or an autoimmune reaction inflammation and pain occur. These are marked by specific molecular patterns and immunological pathways that lead to chondrolysis and destruction of cartilage. …”
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Porphyric encephalopathy in a 15-year-old girl: A case report by Saihari S Dukkipati, Jordan Terschluse, Drew Thodeson, Angela Beavers, Melissa Muff-Luett, Claire Ives, Sookyong Koh

“…Extensive evaluation for infection, toxic metabolic, autoimmune disorders, and vasculitis were negative. …”
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Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases by Carmen Rodriguez-Cerdeira, Elena Sanchez-Blanco, Alberto Molares-Vila

“…There are new applications for these macrolides that have been available for several years and have been applied to skin and hair disorders such as atopic dermatitis, oral lichen planus, vitiligo, chronic autoimmune urticaria, rosacea, alopecia areata, pyoderma gangrenosum, Behcet’s disease, neutrophilic dermatosis, and lupus erythematosus. …”
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The Clinical Trials of Mesenchymal Stromal Cells Therapy by Mohammad Reza Kouchakian, Neda Baghban, Seyedeh Farzaneh Moniri, Mandana Baghban, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Zahra Safaei, Safoura Izanlou, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Amin Tamadon

“…Safety, accessibility, and isolation from patients without ethical concern make MSCs valuable sources for cell therapy approaches in autoimmune, inflammatory, and degenerative diseases. …”
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A Case Report of an Atypical Presentation of IgG4-Related Disease and Idiopathic CD4 Lymphocytopenia by Francesco Rapisarda, Luca Zanoli, Grazia Portale, Salvo Scuto, Pietro Castellino

“…Idiopathic CD4 lymphocytopenia has been associated with a number of autoimmune conditions but, to the best of our knowledge, this is the first case in which an association with the IgG4-related disease is reported.…”
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Ocular comorbidities and its relation to clinical and dermoscopic features in patients with alopecia areata: a case-control study by Eman R. M. Hofny, Ahmed F. Omar, Walaa M. Abdel Megeed, Ayman M. Mahran

“…Background Alopecia Areata (AA) is considered a systemic autoimmune disease that can be associated with several comorbidities. …”
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Prevalence of dry eye disease in rheumatoid arthritis patients and its correlation with duration of rheumatoid arthritis by Priyanshi Ashishbhai Gandhi, Arun Kumar Samar, Nitish Kathuria, Avinash Mishra, Harbeer Singh Chhabra

“…Rheumatoid arthritis (RA) is a systemic autoimmune disease with approximately 25% of patients having ocular manifestations. …”
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