Intrathecal Immunoglobulin A Synthesis in Multiple Sclerosis: From Biological Aspects to Clinical Relevance by Dariia Kliushnikova, Ferdinand Otto, Georg Pilz, Peter Wipfler, Andrea Harrer

“…Recent observations, however, highlight the migration of immune regulatory IgA-producing plasma cells from the gut to the central nervous system (CNS) in experimental autoimmune encephalitis models. A connection between intrathecal IgA synthesis and the gut–brain axis in MS was further corroborated by the discovery of gut microbiota-specific IgA+ B cells in human CNS during relapse. …”
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Plasma MicroRNA Expression Profiles in Psoriasis by Shiju Xiao, Xin Liu, Xiaoxu Wang, Hongpeng Lv, Junbo Zhao, Xinwei Guo, Fuyang Xian, Yunrun Ji, Guangzhong Zhang

“…Although differential expression of miRNAs has been reported in certain inflammatory autoimmune diseases, their role in psoriasis has not been fully illuminated. …”
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Rules for investigation of patients with asymptomatic elevation of serum aminotransferase activity by M. V. Mayevskaya, V. T. Ivashkin, Ye. N. German

“…Screening markers and specifying diagnostic tests are necessary to diagnose correct the majority of liver diseases – viral hepatites, alcoholic (ALD) and non-alcoholic fatty liver diseases (NAFLD), autoimmune hepatitis (AIH), Wilson diseases, primary hemochromatosis etc. …”
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Cholestatic Hepatocellular Injury with Azathioprine: A Case Report and Review of the Mechanisms of Hepatotoxicity by Joseph Romagnuolo, DC Sadowski, E Lalor, L Jewell, ABR Thomson

“…Azathioprine is a drug commonly used for the treatment of inflammatory bowel disease, organ transplantation and various autoimmune diseases. Hepatotoxicity is a rare, but important complication of this drug. …”
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Coexistence of anti-glomerular basement membrane disease and IgA nephropathy: an illustrative case and comprehensive literature review by Zewei Chen, Dechao Xu, Fangzheng Cui, Huihui Hou, Zhiguo Mao, Xiang Gao

“…Anti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. …”
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Osthole regulates N6‐methyladenosine‐modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease by Xian Lin, Jian Chen, Cheng Tao, Lianxiang Luo, Juan He, Qingwen Wang

“…Abstract Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, and RA interstitial lung disease (ILD) is a severe complication of RA. …”
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Periodontal Diseases and Dental Caries in Children with Type 1 Diabetes Mellitus by Marta Novotna, Stepan Podzimek, Zdenek Broukal, Erika Lencova, Jana Duskova

“…Type 1 diabetes mellitus is a chronic metabolic disease of an autoimmune origin with early manifestation predominantly in the childhood. …”
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The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis by Zebrowska Agnieszka, Erkiert-Polguj Anna, Wagrowska-Danilewicz Malgorzata, Danilewicz Marian, Sysa-Jedrzejowska Anna, Anna Cynkier, Waszczykowska Elzbieta

“…The role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis. …”
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Venous thromboembolism in bullous pemphigoid: current evidence and update on systematic review by Atheer G. Almutairi, Abeer G. Almutairi, Rahaf R. Almutairi, Asem Shadid, Alhanouf A. Bin Dakhil, Lamia Alakrash

“…Individuals with systemic autoimmune diseases were found to have a 1.5 to 4 times higher likelihood of developing VTE. …”
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Systemic Sclerosis in Males—Deciphering the Enigma of Erasmus Syndrome by Reena K. Sharma, Mudita Gupta

“…Background: Systemic sclerosis is an autoimmune connective tissue disease characterized by fibrosis in skin and internal organs. …”
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CIRCADIAN RHYTHM AND INDICATORS OF SYSTEMIC INFLAMMATION IN PATIENTS WITH PSORIASIS AND CONCOMITANT ALIMENTARY OBESITY by Ya.O. Yemchenko, K.Ye. Ishcheikin, I.P. Kaidashev

“…There is a theoretical justification for a possible role of circadian rhythm disorders, manifested by changes in eating behavior, reduced sleep duration, and individual chronotype of patients in the development of obesity, chronic low-intensity inflammation, and some chronic autoimmune diseases such as psoriasis. However, this issue remains understudied and insufficiently substantiated. …”
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Anti-NMDA Receptor Encephalitis in a Patient with Previous Psychosis and Neurological Abnormalities: A Diagnostic Challenge by R. David Heekin, Maria C. Catalano, Alfred T. Frontera, Glenn Catalano

“…Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder characterized by IgG autoantibodies directed against the NR1 subunit of the NMDA glutamate receptor. …”
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Lipid and Bile Acid Dysmetabolism in Crohn’s Disease by Koji Uchiyama, Hisashi Kishi, Wataru Komatsu, Masanori Nagao, Shuji Ohhira, Gen Kobashi

“…Crohn’s disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. …”
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The Role of Genetic and Immune Factors for the Pathogenesis of Primary Sclerosing Cholangitis in Childhood by Priscila Menezes Ferri, Ana Cristina Simões e Silva, Soraya Luiza Campos Silva, Diego Junior Queiroga de Aquino, Eleonora Druve Tavares Fagundes, Débora Marques de Miranda, Alexandre Rodrigues Ferreira

“…Differences in clinical and laboratory findings were observed in young patients, including higher incidence of overlap syndromes, mostly with autoimmune hepatitis, higher serum levels of aminotransferases and gamma-glutamyl transferase, and lower incidence of serious complications as cholangiocarcinoma. …”
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Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria by Jinyun Chen, Qian Wang, Xuebing Feng, Zhuoya Zhang, Linyu Geng, Ting Xu, Dandan Wang, Lingyun Sun

“…Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE). …”
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Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis by Sunish Mohanan, Brian D. Cherrington, Sachi Horibata, John L. McElwee, Paul R. Thompson, Scott A. Coonrod

“…Recent reviews on PADs have focused on their role in autoimmune diseases. Here, we will discuss the potential role of PADs in tumor progression and tumor-associated inflammation. …”
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Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis by Dagmara Weronika Wojkowska, Piotr Szpakowski, Dominika Ksiazek-Winiarek, Marcin Leszczynski, Andrzej Glabinski

“…Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) in which activated T cell and neutrophil interactions lead to neuroinflammation. …”
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Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice by Dina Silke Malling Damlund, Stine Broeng Metzdorff, Jane Preuss Hasselby, Maria Wiese, Mia Lundsager, Dennis Sandris Nielsen, Karsten Stig Buschard, Axel Kornerup Hansen, Hanne Frøkiær

“…The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking. …”
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Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association by Lorenzo Cavagna, Nicola Boffini, Giovanni Cagnotto, Flora Inverardi, Vittorio Grosso, Roberto Caporali

“…Moreover, atherosclerosis may be directly mediated also by underlying autoimmune processes, and indirectly by the occurrence of metabolic syndrome and impaired physical activity. …”
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Problems with studying directional natural selection in humans by S. V. Mikhailova

“…The results obtained by various methods indicate that the direction of human adaptation to new food products has not changed during evolution since the Neolithic; many variants of immunity genes associated with inflammatory and autoimmune diseases in modern populations have undergone positive selection over the past 2–3 thousand years owing to the spread of bacterial and viral infections. …”
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