Lipschütz Genital Ulceration as Initial Manifestation of Primary Sjögren’s Syndrome by Filipa de Castro Coelho, Maria Amaral, Lúcia Correia, Maria João Nunes Campos, Tereza Paula, Augusta Borges, Jorge Borrego

“…Reactive acute genital ulcers (Lipschütz ulcers) should be considered as a possible manifestation of many autoimmune/inflammatory disorders, beyond the classic associations such as Behçet’s syndrome or Crohn’s disease.…”
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Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report by Ambika Shivarajpur, Simon Londono, Justin Shaw, Christopher Boccio, Leonid Melnitsky, Jheanelle McKay, Brian Kohen, Eric Boccio

“…The condition is often idiopathic but can be associated with infections, neoplasms, autoimmune disorders, and certain drugs. Case Report: A 91-year-old female with past medical history of Alzheimer dementia and hypertension, being treated for lower extremity cellulitis, presented to the emergency department for an allergic reaction. …”
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Recapitulation of Candidate Systemic Lupus Erythematosus-Associated Variants in Koreans by Ki-Sung Kwon, Hye-Young Cho, Yeun-Jun Chung

“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. …”
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Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…These processes also occur in autoimmune diseases, especially inflammatory bowel disease (IBD). …”
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Ultrasonography of articular and periarticular structures as a relapse predictor in patients with clinically remitted rheumatoid arthritis by Mehdi Karami, Zohre Mohammadzadeh, Shadi Ebrahimian, Maryam Moradi, Sayedbonakdar Zahra

“…Introduction: Rheumatoid arthritis (RA) is an autoimmune disease causing mortality and morbidity among patients. …”
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The Regulation between CD4+CXCR5+ Follicular Helper T (Tfh) Cells and CD19+CD24hiCD38hi Regulatory B (Breg) Cells in Gastric Cancer by Ying Zhang, Jun Wu, Haibo Zhang, Chen Wu

“…T follicular helper (Tfh) cells and regulatory B (Breg) cells are reported to play essential roles in humoral immunity, especially in inflammation, autoimmune diseases, and cancer. Hence, we sought to investigate the involvement of CXCR5+CD4+ Tfh cells and CD19+CD24hiCD38hi Breg cells in gastric cancer. …”
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Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy by Amandeep Singh, Nayere Zaeri, Immanuel K. Ho

“…Patients treated with interferon (IFN) based therapies may develop exacerbation of autoimmune disease. We herein present the case of a 53-year-old female patient who developed celiac disease (CD) as a result of triple therapy (interferon, ribavirin, and boceprevir) for chronic HCV. …”
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Cytokines and HCV-Related Disorders by Poupak Fallahi, Clodoveo Ferri, Silvia Martina Ferrari, Alda Corrado, Domenico Sansonno, Alessandro Antonelli

“…The most important systemic HCV-related extrahepatic diseases—mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes—are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. …”
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Whole Exome Sequencing and Molecular Modeling of a Missense Variant in TNFAIP3 That Segregates with Disease in a Family with Chronic Urticaria and Angioedema by Antoneicka L. Harris, Patrick R. Blackburn, John E. Richter, Jennifer M. Gass, Thomas R. Caulfield, Ahmed N. Mohammad, Paldeep S. Atwal

“…Variants in TNFAIP3 have been associated with multiple autoimmune diseases, susceptibility to allergy and asthma, and periodic fever syndromes, suggesting that this variant could potentially play a role in disease.…”
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A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma by Keiki Nagaharu, Yuka Sugimoto, Keiki Kawakami

“…Immunotactoid glomerulopathy (ITG) is characterized by Congo red-negative microtubular deposits, and it has been reported as a rare paraneoplastic syndrome due to hematologic malignancies, viral infections, or autoimmune diseases. In hematologic malignancies, multiple myeloma and other mature B-cell malignancies are the most common hematologic malignancies, and Hodgkin lymphoma (HL) is extremely rare. …”
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Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor by Taichi Sugawara, Kayoko Sonoda, Nattapran Chompusri, Kazuhiro Noguchi, Seiji Okada, Mikio Furuse, Tomohiko Wakayama

“…Abstract Tight junctions (TJs) between adjacent Sertoli cells are believed to form immunological barriers that protect spermatogenic cells expressing autoantigens from autoimmune responses. However, there is no direct evidence that Sertoli cell TJs (SCTJs) do indeed form immunological barriers. …”
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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling

“…Therapeutic protein products (TPP) have been widely used to treat a variety of human diseases, including cancer, hemophilia, and autoimmune diseases. However, TPP can induce unwanted immune responses that can impact both drug efficacy and patient safety. …”
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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients by Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo

“…Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. …”
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Interleukin-15 and Tumor Necrosis Factor-α in Iraqi Patients with Alopecia Areata by Zainab A. Kamil, Galawish A. Abdullah, Haider Hashim Zalzala

“…Most evidence supports the hypothesis that it is disease of the hair follicle of autoimmune nature mediated by T-cells, with important cytokine role. …”
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Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report by Nobuki Shioya, Shigehiro Shibata, Masahiro Kojika, Shigeatsu Endo

“…The present case highlights the need for exercising caution while prescribing slow-release nonsteroidal anti-inflammatory drugs with corticosteroids to patients with autoimmune diseases, as such treatment may exacerbate intestinal epithelial abnormalities.…”
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Natural regulatory T cells increase significantly in pediatric patients with parasitic infections: Flow cytometry study by Nadeem Kizilbash, Nida Suhail, A. Khuzaim Alzahrani, W. Jamith Basha, Mohamed Soliman

“…The Tregs maintain tolerance to self-antigens and prevent autoimmune diseases. Aim: The purpose of this study was to determine the difference in natural Treg levels in Entamoeba histolytica, Schistosoma mansoni, Giardia lamblia, Enterobius vermicularis, and Hymenolepis nana infected patients. …”
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Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis by Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei, Chun Wang

“…Rheumatoid arthritis (RA) is a chronic, persistent autoimmune disease that causes severe joint tissue damage and irreversible disability. …”
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Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed? by Jiayu Zhai, Ju Rong, Qiuxia Li, Jieruo Gu

“…Ankylosing spondylitis (AS) is a systemic, autoimmune disease resulting in the destruction of the affected joints. …”
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Cryotherapy versus fractional carbon dioxide laser in patchy alopecia areata: a self-controlled comparative study by Ahmed A. Afify, Maha A. Shaheen, Mays Q. Ojaimi

“…Introduction Alopecia areata (AA) is an autoimmune noncicatricial alopecia. Many treatments are available but with variable results. …”
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Systemic Sclerosis and Multiple Cancers of the Female Genital Tract: Prolonged Survival following Current Treatment Strategies by Georgios Androutsopoulos, Georgios Adonakis, Athanasios Tsamandas, Andreas Andonopoulos, Georgios Decavalas

“…Systemic sclerosis is a rare, chronic, multisystem, and autoimmune disease. There is an overall increased risk of malignancy in patients with systemic sclerosis. …”
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