Panitumumab plus 5-fluorouracil and folinic acid or 5-fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212... by Arndt Stahler, Meinolf Karthaus, Stefan Fruehauf, Ullrich Graeven, Lothar Müller, Ludwig Fischer von Weikersthal, Karel Caca, Eray Goekkurt, Alexej Ballhausen, Greta Sommerhäuser, Annabel H.S. Alig, Swantje Held, Armin Jarosch, David Horst, Anke Reinacher-Schick, Stefan Kasper, Volker Heinemann, Sebastian Stintzing, Tanja Trarbach, Dominik P. Modest

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Spatio-temporal evolution and simulation of soil salinization in typical oasis water-saving irrigation area based on long series data by Wenhao Li, Shuanglong Gao, Dongjie Pei, Yue Wen, Xiaoguo Mu, Mengjie Liu, Zhenhua Wang

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Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

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Chronic Airflow Limitation, Lower Respiratory Symptoms, COPD and Chronic Rhinosinusitis in a Middle-Aged Population: The Swedish CArdioPulmonary bioImage Study (SCAPIS). A Link Bet... by Andersson A, Bergqvist J, Schiöler L, Bossios A, Farnebo L, Holmlund T, Janson C, Keceli S, Ljunggren M, Malinovschi A, Memarian E, Nihlén U, Nilsson PM, Pesonen I, Sjöström M, Stenfors N, Sundbom F, Werner M, Torén K, Sköld M, Hellgren J

“…Anders Andersson,1,2,* Joel Bergqvist,3,4,* Linus Schiöler,5 Apostolos Bossios,6,7 Lovisa Farnebo,8,9 Thorbjörn Holmlund,10 Christer Janson,11 Sumru Keceli,12 Mirjam Ljunggren,11 Andrei Malinovschi,13 Ensieh Memarian,14 Ulf Nihlén,15 Peter M Nilsson,16,17 Ida Pesonen,18,19 Marcus Sjöström,10 Nikolai Stenfors,20 Fredrik Sundbom,11 Mimmi Werner,10 Kjell Torén,5,21 Magnus Sköld,22,23 Johan Hellgren24,25 1COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden; 2COPD Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 3Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden; 4Centre for Sleep and Wake Disorders, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 5Occupational and Environmental Medicine, School of Public Health and Community Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 6Karolinska Severe Asthma Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden; 7Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 8Linköping University Faculty of Medicine and Health Sciences, Department of Biomedical and Clinical Sciences, Division of Sensory Organs and Communication, Linköping, Sweden; 9Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Otorhinolaryngology, Linköping, Sweden; 10Department of Clinical Sciences, Otorhinolaryngology, Umeå University, Umeå, Sweden; 11Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; 12Department of Otorhinolaryngology in Linköping, Region Östergötland, Linköping, Sweden; 13Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden; 14Department of Clinical Sciences, IKVM, Internal Medicine, Lund University, Malmö, Sweden; 15Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund University, Lund, Sweden; 16Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; 17Clinical Research Unit, Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden; 18Respiratory Medicine Unit, Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden; 19Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden; 20Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; 21Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; 22Department of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden; 23Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; 24Department of Otorhinolaryngology, Head & Neck Surgery, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden; 25Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden*These authors contributed equally to this workCorrespondence: Anders Andersson, COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Bruna Stråket 11B, Göteborg, 413 46, Sweden, Email Anders.Andersson@lungall.gu.sePurpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). …”
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Research note: The critical role of the interaction between Eimeria tenella invasion protein RON2 and host receptor annexin A2 in mediating parasite invasion by Junli Ni, Xiangjie Chen, Yunyun Sun, Yibin Zhu, Haiming Cai, Yongle Song, Minna Lv, Juan Li, Shenquan Liao, Nanshan Qi, Mingfei Sun, Jianfei Zhang, Youfang Gu, Xinchao Liu, Xuhui Lin

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Climate change rivals fertilizer use in driving soil nitrous oxide emissions in the northern high latitudes: Insights from terrestrial biosphere models by Naiqing Pan, Hanqin Tian, Hao Shi, Shufen Pan, Josep G. Canadell, Jinfeng Chang, Philippe Ciais, Eric A. Davidson, Gustaf Hugelius, Akihiko Ito, Robert B. Jackson, Fortunat Joos, Sebastian Lienert, Dylan B. Millet, Stefan Olin, Prabir K. Patra, Rona L. Thompson, Nicolas Vuichard, Kelley C. Wells, Chris Wilson, Yongfa You, Sönke Zaehle

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Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition by Yasmin F Melzer, Nadine L Fergen, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Ysabel A Schwietzer, Julian Kött, Klaus Pantel, Stefan W Schneider, Jochen Utikal, Ewa Wladykowski, Sabine Vidal-y-Sy, Alexander T Bauer, Christoffer Gebhardt

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Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Jan-Hendrik Bockmann, Lena Allweiss, Annika Volmari, David da Fonseca Araújo, Matin Kohsar, Anastasia Hyrina, Janine Kah, Zhijuan Song, Josolyn Chan, Katja Giersch, Tassilo Volz, Marc Lütgehetmann, Jeffrey J. Wallin, Dmitry Manuilov, Meghan M. Holdorf, Simon P. Fletcher, Ansgar W. Lohse, Antonio Bertoletti, Julian Schulze zur Wiesch, Maura Dandri

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Effectiveness of a universal film intervention in reducing violence against children and increasing positive parenting among migrant and displaced caregivers from Myanmar: a commun... by Amanda Sim, Khaing Zar Lwin, Stephanie Eagling-Peche, G.J. Melendez-Torres, Seema Vyas, Francisco Calderon, Tawanchai Jirapramukpitak, Jamie Lachman, Sureeporn Punpuing, Andrea Gonzalez, Mary Soan, Nway Nway Oo, Ivet Castello Mitjans, Greg Tyrosvoutis, Eve Puffer

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Overwintering temperature affects lipid and fatty acid metabolism in hepatopancreas and ovary of female mud crab Scylla paramamosain by Kaijia Yu, Hanying Xu, Ce Shi, Chunlin Wang, Changkao Mu, Yangfang Ye, Shujian Chen, Ronghua Li, Qingyang Wu

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Association between dietary patterns and glycemic control in type II diabetes mellitus patients by Ye Qiang, Xingchen Lu, Yuchao Zhang

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Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator’s Consortium Registry Analysis by Margaret Stalker, MD, Connor B. Grady, MPH, Alex Watts, MS, Wei-Ting Hwang, PhD, Krishna Chandrasekhara, MS, Fangdi Sun, MD, Geoffrey Liu, MD, Devalben Patel, MD, Jorge Nieva, MD, Amanda Herrmann, MD, Kristen Marrone, MD, Vincent K. Lam, MD, Vamsidhar Velcheti, MD, Stephen V. Liu, MD, Gabriela Liliana Bravo Montenegro, MD, William Tompkins, MD, Tejas Patil, MD, Jared Weiss, MD, Kelsey Leigh Miller, MD, William Schwartzman, MD, Jonathan E. Dowell, MD, Khvaramze Shaverdashvili, MD, PhD, Liza Villaruz, MD, Amanda Cass, PharmD, Wade Iams, MD, Dara Aisner, MD, PhD, Charu Aggarwal, MD, MD, D. Ross Camidge, MD, PhD, Lova Sun, MD, Melina E. Marmarelis, MD

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Implementation of in utero laparotomy-assisted fetoscopic spina bifida repair in two centers in Latin America: rationale for this approach in this regionAJOG Global Reports at a Gl... by Jezid Miranda, PhD, Miguel A. Parra-Saavedra, PhD, William O. Contreras-Lopez, PhD, Cristóbal Abello, MD, Guido Parra, MD, Juan Hernandez, MD, Amanda Barrero, MD, Isabela Leones, MD, Adriana Nieto-Sanjuanero, MD, Gerardo Sepúlveda-Gonzalez, MD, Magdalena Sanz-Cortes, PhD

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In vitro antidiabetic activity of facheiro (Pilosocereus pachycladus) mucilage and its effects on glycaemic, renal and hepatic parameters in obese rats by Fabrícia de Souza Ferreira, Hassler Clementino Cavalcante, Larissa Maria Gomes Dutra, Adriano Francisco Alves, Stephson Andriola Almeida Gonçalves, Tatiana Colombo Pimentel, Carlos Eduardo Barão, Marcos dos Santos Lima, Alana Natalícia Vasconcelos de Araújo, Januse Millia Dantas de Araújo, Kamila Sabino Batista, Jailane de Souza Aquino, Angela Maria Tribuzy de Magalhães Cordeiro

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Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context by Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, J.E. Martens, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, M. Engelen

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Farmers’ climate change perception, impacts and adaptation strategies in response to drought in the Northwest area of Bangladesh by J.M. Adeeb Salman Chowdhury, Md. Abdul Khalek, Md. Kamruzzaman

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New rectum dose surface mapping methodology to identify rectal subregions associated with toxicities following prostate cancer radiotherapy by Artemis Bouzaki, Dylan Green, Marcel van Herk, Jane Shortall, Tanuj Puri, Sarah Kerns, David Azria, Marrie-Pierre Farcy-Jacquet, Jenny Chang-Claude, Ananya Choudhury, Alison Dunning, Maarten Lambrecht, Barbara Avuzzi, Dirk De Ruysscher, Petra Seibold, Elena Sperk, Christopher Talbot, Ana Vega, Liv Veldeman, Adam Webb, Barry Rosenstein, Catharine M. West, Eliana Gioscio, Tiziana Rancati, Eliana Vasquez Osorio, Alan McWilliam

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Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics by Nils A. Koch, Benjamin W. Corrigan, Michael Feyerabend, Roberto A. Gulli, Michelle S. Jimenez-Sosa, Mohamad Abbass, Julia K. Sunstrum, Sara Matovic, Megan Roussy, Rogelio Luna, Samuel A. Mestern, Borna Mahmoudian, Susheel Vijayraghavan, Hiroyuki Igarashi, Kartik S. Pradeepan, William J. Assis, J. Andrew Pruszynski, Shreejoy Tripathy, Jochen F. Staiger, Guillermo Gonzalez-Burgos, Andreas Neef, Stefan Treue, Stefan Everling, Wataru Inoue, Anmar Khadra, Julio C. Martinez-Trujillo

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GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem by Cecilia Hes, Lu Ting Gui, Alexandre Bay, Fernando Alvarez, Pierce Katz, Tanushree Paul, Nadejda Bozadjieva-Kramer, Randy J. Seeley, Ciriaco A. Piccirillo, Paul V. Sabatini

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Clinical trials to gene therapy development and production in Brazil: a review by Jonas Alex Morales Saute, Virginia Picanço-Castro, Ana Carolina de Freitas Lopes, João Batista da Silva Júnior, Johanna Henriques Nehm, Franciele dos Santos Maciel, Ida Vanessa Doederlein Schwartz, Juliana Maria Ferraz Sallum, Margareth Castro Ozelo, Roberto Giugliani, Martin Bonamino, Hilda Petrs-Silva, Guilherme Baldo

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