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    Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review by Bashir MBA, Milani GP, De Cosmi V, Mazzocchi A, Zhang G, Basna R, Hedman L, Lindberg A, Ekerljung L, Axelsson M, Vanfleteren LEGW, Rönmark E, Backman H, Kankaanranta H, Nwaru BI

    Published 2025-02-01
    “…Muwada Bashir Awad Bashir,1 Gregorio Paolo Milani,2,3,* Valentina De Cosmi,4,5,* Alessandra Mazzocchi,3,* Guoqiang Zhang,1 Rani Basna,1 Linnea Hedman,6 Anne Lindberg,7 Linda Ekerljung,1 Malin Axelsson,8 Lowie EGW Vanfleteren,9 Eva Rönmark,6 Helena Backman,6 Hannu Kankaanranta,1,10,11 Bright I Nwaru1,12 1Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; 2Pediatric Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; 3Department of Clinical Science and Community Health, University of Milan, Milan, Italy; 4Department of Food Safety, Nutrition and Veterinary Public Health, Instituto Superiore Di Sanità - Italian National Institute of Health, Roma, Italy; 5Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy; 6Department of Public Health and Clinical Medicine, Section of Sustainable Health/ the OLIN Unit, Umeå University, Umeå, Sweden; 7Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; 8Department of Care Science, Faculty of Health and Society, Malmö University, Malmö, Sweden; 9COPD Center, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden; 10Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; 11Tampere University Respiratory Research Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; 12Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden*These authors contributed equally to this workCorrespondence: Muwada Bashir Awad Bashir, Krefting Research Centre, Institute of Medicine, University of Gothenburg, P.O. …”
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    Small Extracellular Vesicles from Young Healthy Human Plasma Inhibit Cardiac Fibrosis After Myocardial Infarction via miR-664a-3p Targeting SMAD4 by Wang W, Li Y, Zhang C, Zhou H, Li C, Cheng R, Chen X, Pu Y, Chen Y

    Published 2025-01-01
    “…Weiwei Wang,1,* Ying Li,1,* Cheng Zhang,2,* Haoyang Zhou,1 Chunyu Li,3 Rong Cheng,1 Xufeng Chen,1 Yanan Pu,4 Yan Chen1,5,6 1Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Long Jiang Central Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 3Long Jiang Intensive Care Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 4Department of Clinical Laboratory, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 5Department of Emergency and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215000, People’s Republic of China; 6Department of Emergency Management, School of Health Policy & Management, Nanjing Medical University, Nanjing, 211166, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Chen; Yanan Pu, Email chenyandoc@njmu.edu.cn; pyn342626@njmu.edu.cnPurpose: Cardiac fibrosis, a key contributor to ventricular pathologic remodeling and heart failure, currently lacks effective therapeutic approaches.Patients and Methods: Small extracellular vesicles from young healthy human plasma (Young-sEVs) were characterized via protein marker, transmission electron microscopy, and nanoparticle tracking analysis, then applied in cellular models and mouse models of cardiac fibrosis. …”
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