Years of Life Lost due to Premature Mortality in Russia, 1990-2021 by Anastasiya I. Pyankova, Timur A. Fattakhov, Mikhail B. Denisenko

“…Still, it was 1.5 and 1.3 times higher than the similar rates for men and women in the WHO European Region. The authors sought to trace the evolution of the structural characteristics of years of life lost in Russia from 1990 to 2021 and identify the factors that led to such a significant gap in the level of losses from premature mortality. …”
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An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure by Seth Kwadjo Angmorterh, Andrew England, Sonia Aboagye, Eric Kwasi Ofori, Peter Hogg

“…PUs creates a huge financial burden on healthcare authorities and patients, costing billions to treat and manage. …”
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Acceptability of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine in Papua New Guinea: a qualitative stu... by Elvin Lufele, Sophie Pascoe, Alice Mengi, Alma Auwun, Nalisa Neuendorf, John W. Bolnga, Moses Laman, Stephen J. Rogerson, Kamala Thriemer, Holger W. Unger

“…IDIs were conducted with: (1) trial participants at different stages of engagement with ANC and IPTp, e.g. first antenatal clinic visit, subsequent antenatal clinic visits and postpartum; (2) local health workers (nurses, community health workers, midwives, health extension officers, doctors); and (3) representatives of district, provincial and national health authorities involved in programming ANC and IPTp. Focus group discussions comprised pregnant women only, including those engaged in the clinical trial and those receiving routine ANC outside of the trial. …”
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Prevalence of Insomnia and Related Factors Among Cancer Outpatients in China by Zhao K, Yu Z, Wang Y, Feng W

“…Kuan Zhao,1,2,* Ze Yu,1,2,* Youyang Wang,1,2 Wei Feng1,2 1Department of Psychological Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Feng, Department of Psychological Medicine, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, People’s Republic of China, Email ffww06@163.comBackground: The incidence of insomnia in cancer patients is significantly higher than in the general population. …”
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EASTERN SPIRITUAL TRADITIONS THROUGH THE LENS OF MODERN SCIENTIFIC WORLDVIEW by Tetiana V. Danylova

“…This paper aims to analyze Eastern spiritual traditions in the context of modern scientific worldview. Methodology. The author has used hermeneutical methodology, along with integrative approach. …”
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Features of the use of physical exercises at the long-term stage of rehabilitation after intra-articular fractures by Sviatoslava Pashkevych, Tetiana Shutieieva, Оlha Beziazychna

“…It is recommended to perform exercises with an emphasis on the posterior surface of the lower extremity. The author's program of physical rehabilitation is quite conditional. …”
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Construction of an Interpretable Model of the Risk of Post-Traumatic Brain Infarction Based on Machine Learning Algorithms: A Retrospective Study by Li S, Li H, Wu B, Pan R, Liu Y, Wang J, Wei D, Gao H

“…Shaoji Li,1,* Hongjian Li,2,* Baofang Wu,1,* Rujun Pan,3 Yuqi Liu,4 Jiayin Wang,1 De Wei,3 Hongzhi Gao1 1Department of Neurosurgery, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China; 2School of Medical Imaging, North Sichuan Medical College, Nanchong, 634700, People’s Republic of China; 3Department of Neurosurgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, People’s Republic of China; 4Department of Intensive Care Unit, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China*These authors contributed equally to this workCorrespondence: De Wei; Hongzhi Gao, Email weidele@fjmu.edu.cn; gaohongzhi@fjmu.edu.cnBackground: Post-traumatic cerebral infarction (PTCI) is a severe complication resulting from traumatic brain injury (TBI), which can lead to permanent neurological damage or death. …”
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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…Shuhan Liu,1– 3 Haisong Li,4 Shiwen Xi,1,2 Yuning Zhang,1,2,* Tianmeng Sun1,2,5,6,* 1Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 2National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, People’s Republic of China; 3Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 5International Center of Future Science, Jilin University, Changchun, People’s Republic of China; 6State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianmeng Sun; Yuning Zhang, The First Hospital of Jilin University, 71 Xinmin St, Changchun, Jilin, People’s Republic of China, Email tsun41@jlu.edu.cn; zhangyuning@jlu.edu.cnAbstract: Given the complexity of the central nervous system (CNS) and the diversity of neurological conditions, the increasing prevalence of neurological disorders poses a significant challenge to modern medicine. …”
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The Role of Fatigue in Return to Sport Testing Following Anterior Cruciate Ligament Reconstruction by Justin C Tallard, Corbin Hedt, Bradley S Lambert, Patrick C McCulloch

“… # Purpose/Hypothesis The purpose of this study was to assess the effect of fatigue on performance of various hop tests used in clinical rehabilitation settings by examining LSI scores. The authors hypothesized that participants will have worse limb symmetry index scores following the fatigue protocol and that the operative limb (ACLR) will have a greater decline in function than the non-operative limb (CON)…”
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Barriers and enablers to implementing clinical practice guidelines in primary care: an overview of systematic reviews by Tao Wang, Xian-Liang Liu, Jing-Yu (Benjamin) Tan, Isabella Zhao

“…Objectives To identify the barriers and enablers to implementing clinical practice guidelines (CPGs) recommendations in primary care and to provide recommendations that could facilitate the uptake of CPGs recommendations.Design An overview of systematic reviews.Data sources Nine electronic databases (PubMed, Cochrane Library, CINAHL, MEDLINE, PsycINFO, Web of Science, Journals @Ovid Full Text, EMBase, JBI) and three online data sources for guidelines (Turning Research Into Practice, the National Guideline Clearinghouse and the National Institute for Health and Care Excellence) were searched until May 2021.Eligibility criteria Systematic reviews, meta-analyses or other types of systematic synthesis of quantitative, qualitative or mixed-methods studies on the topic of barriers and/or enablers for CPGs implementation in primary care were included.Data extraction and synthesis Two authors independently screened the studies and extracted the data using a predesigned data extraction form. …”
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Impact of Preoperative Daytime Sleepiness and Insomnia on Therapy Adherence and Neurostimulation Amplitude in Unilateral Hypoglossal Nerve Stimulation by Pordzik J, Ludwig K, Ruckes C, Gouveris H

“…Johannes Pordzik,1,* Katharina Ludwig,1,* Christian Ruckes,2 Haralampos Gouveris1 1Department of Otolaryngology/Head and Neck Surgery & Sleep Medicine Center, University Medical Center Mainz, Mainz, 55131, Germany; 2Interdisciplinary Center for Clinical Trials, University Medical Center Mainz, Mainz, 55131, Germany*These authors contributed equally to this workCorrespondence: Haralampos Gouveris, Email haralampos.gouveris@unimedizin-mainz.deIntroduction: Average adherence to hypoglossal nerve stimulation (HGNS) therapy is more than 5 h/night. …”
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Arsitektur Sistem Percakapan Otomatis Berbahasa Indonesia dengan Normalisasi Bahasa Informal Menjadi Baku by Muhammad Fathur Rahman Khairul, Rizal Setya Perdana

“…NLP generally only works with formal language and is unable to interpret the meaning of informal sentences. Therefore, the authors propose an approach to enable machines to understand informal language by normalizing the informal language to standard by utilizing NLP. …”
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Peningkatan Akurasi Klasifikasi Algoritma C 4.5 Menggunakan Teknik Bagging pada Diagnosis Penyakit Jantung by Erwin Prasetyo, Budi Prasetiyo

“…Heart disease data is taken from the UCI Machine Learning Repository dataset. The purpose of the authors conducting this research is to determine the application of bagging techniques on the C4.5 algorithm, determine the accuracy of the results in the C4.5 algorithm, and compare the level of accuracy of the application of bagging techniques on the C4.5 algorithm. …”
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Eastern Spiritual Traditions Through the Lens of Modern Scientific Worldview by Tetiana V. Danylova

“…This paper aims to analyze Eastern spiritual traditions in the context of modern scientific worldview. Methodology. The author has used hermeneutical methodology, along with integrative approach. …”
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Shoulder Isokinetic Strength Balance Ratio in Overhead Athletes: A Cross-Sectional Study by Valentine Zimermann Vargas, Caroline Motta, Rodrigo Luiz Vancini, Claudio Andre Barbosa de Lira, Marilia Santos Andrade

“…As there were several differences between the overhead sports according to the FRs, the authors suggest caution in grouping overhead athletes across multiple sports. …”
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Clinical Characteristics and Risk Factors for Multidrug-Resistant Enterobacter cloacae Complex Bacteremia in a Chinese Tertiary Hospital: A Decade Review (2013–2022) by Han M, Hua M, Xie H, Li J, Wang Y, Shen H, Cao X

“…Mei Han,1,2,* Miaomiao Hua,3,* Hui Xie,1 Jia Li,1 Yijun Wang,2,4 Han Shen,1 Xiaoli Cao1 1Department of Laboratory Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 2Nanjing Field Epidemiology Training Program, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China; 3Department of Laboratory Medicine, The Affiliated Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, People’s Republic of China; 4Nanjing Jiangning District Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoli Cao; Han Shen, Email cao-xiao-li@163.com; shenhan10366@sina.comObjective: This study aimed to analyze the antimicrobial resistance profiles, clinical characteristics and risk factors of bacteremia caused by Enterobacter cloacae complex (ECC) strains.Methods: We retrospectively collected clinical data from patients diagnosed with ECC bacteremia between 2013 and 2022 in a tertiary hospital in Jiangsu. …”
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Perancangan User Experience Aplikasi Info COVID-19 Menggunakan Metode Human Centered Design by Pradya Mutiarahma, Hanifah Muslimah Az-Zahra, Yusi Tyroni Mursityo

“…Based on that problem, the author provides a solution by designing the user experience of a mobile-based application for COVID-19 information. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Peizhi Lu,1,2,* Ya Li,1,2,* Shuo Yang,2 Haoyu Yao,2 Bizhi Tu,2 Rende Ning1,2 1Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bizhi Tu, Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China, Tel +86 15357483840, Email 1301535636@qq.com Rende Ning, Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China, Tel +86 13956966305, Email nrd1972@outlook.comObjective: The objective of this study was to characterize the activation and differentiation of B cells in the synovium of osteoarthritis (OA) and to explore the underlying molecular mechanisms.Methods: Peripheral blood and synovial samples from OA patients at different stages were collected, and flow cytometry was employed to analyze the activation and differentiation of B cells. …”
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A critical review of data mining in education on the levels and aspects of education by Inusah Fuseini, Yaw Marfo Missah

“…The information presented is the original knowledge of the authors. However, a pre-print of the work is in Research Square.…”
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…Yixian Liu,1,2,* Xiaoyu Li,1,2,* Mengyu Zhang,1,2 Yuchun Men,1,2 Ying Wang,1,2 Xiaohong Zhu,1,2 Li Zheng1,2 1Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Clinical Trial Center, NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zheng, Cancer Center, West China Hospital, Sichuan University, No. 5 Telecom Road, Wuhou District, Chengdu, 610041, People’s Republic of China, Email zhengli@wchscu.cnPurpose: HA121-28, a novel multi-targeting tyrosine kinase inhibitor, has dual efficacy against tumor growth and neovascularization. …”
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