Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions by Yan‐Dong Tang, Yuming Li, Xue‐Hui Cai, Xin Yin

Subjects: Get full text

Expert consensus and recommendations on the live attenuated hepatitis A vaccine and immunization practices in India by Nitin Shah, M.M.A. Faridi, Sheila Bhave, Apurba Ghosh, S. Balasubramanian, Vidya Arankalle, Raju Shah, Amar Jeet Chitkara, Arun Wadhwa, Jaydeep Chaudhry, Ramesh Srinivasan, M. Surendranath, Amita Sapru, Monjori Mitra

Subjects: Get full text

Stability and Efficacy of Live-Attenuated Vibrio harveyi Vaccines Under Different Storage Conditions in Zebrafish (Danio rerio) Models by Mohd Hafiz Ngoo Muhamad-Sofie, Aslah Mohamad, Mohamad Azzam-Sayuti, Mohammad Noor Azmai Amal, Mohd Zamri-Saad, Md Shirajum Monir, Ina Salwany Md Yasin

Subjects: “…live-attenuated vaccine…”
Get full text

Elegant and Innovative Recoding Strategies for Advancing Vaccine Development by François Meurens, Fanny Renois, Uladzimir Karniychuk

Subjects: Get full text

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

Subjects: Get full text

The Strategies Used by Animal Viruses to Antagonize Host Antiviral Innate Immunity: New Clues for Developing Live Attenuated Vaccines (LAVs) by Na Chen, Baoge Zhang

“…As an essential type of vaccine, live attenuated vaccines (LAVs) play a crucial role in animal disease prevention and control. …”
Get full text

The Development of a One-Step PCR Assay for Rapid Detection of an Attenuated Vaccine Strain of Duck Hepatitis Virus Type 3 in Korea by Cheng-Dong Yu, Jong-Yeol Park, Sang-Won Kim, Yu-Ri Choi, Se-Yeoun Cha, Hyung-Kwan Jang, Min Kang, Bai Wei

Get full text

Intussusception associated with rotavirus vaccination in a 2-month-old infant: A case report by Shu-Wei Hu, Min-Yung Kuo, Hueng-Chuen Fan

“…The rotavirus vaccine is a kind of oral live attenuated vaccine approved by the Department of Health in Taiwan since 2006. …”
Get full text

CD8 Knockout Mice Are Protected from Challenge by Vaccination with WR201, a Live Attenuated Mutant of Brucella melitensis by Samuel L. Yingst, Mina Izadjoo, David L. Hoover

“…Mice were immunized orally by administration of B. melitensis WR201, a purine auxotrophic attenuated vaccine strain, then challenged intranasally with B. melitensis 16M. …”
Get full text

Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response by Seunga Choi, Han-Gyu Choi, Ki-Won Shin, Yong Woo Back, Hye-Soo Park, Jae Hwi Lee, Hwa-Jung Kim

“…The attenuated vaccine Mycobacterium bovis BCG (Bacille Calmette Guerin) has limited protective efficacy against TB. …”
Get full text

Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngo... by Gayathri Gopakumar, Mauricio J. C. Coppo, Mauricio J. C. Coppo, Andrés Diaz-Méndez, Carol A. Hartley, Joanne M. Devlin

“…A glycoprotein-G-deleted live-attenuated vaccine strain of the infectious laryngotracheitis virus (ILTV), ΔgG-ILTV, is safe and efficacious against ILTV challenge. …”
Get full text

Genome stability of the vaccine strain VAC∆6 by R. A. Maksyutov, S. N. Yakubitskiy, I. V. Kolosova, T. V. Tregubchak, A. N. Shvalov, E. V. Gavrilova, S. N. Shchelkunov

“…To assess the genome stability of the resulting attenuated vaccine strain, 15 consecutive cycles of cultivation of the industrial VACΔ6 strain were performed in 4647 cells certified for vaccine production in accordance with the “Guidelines for Clinical Trials of Medicinal Products”. …”
Get full text

Development of a recombinant infectious bronchitis virus vaccine expressing infectious laryngotracheitis virus multiple epitopes by Guanming Shao, Jun Fu, Yun Pan, Shiying Gong, Chaoyi Song, Sheng Chen, Keyu Feng, Xinheng Zhang, Qingmei Xie

“…Infectious laryngotracheitis (ILT) is a highly contagious disease, usually controlled by vaccination with live attenuated vaccines. However, the latent infection and adverse reactions caused by the live attenuated vaccines against infectious laryngotracheitis virus (ILTV) have limited its use in poultry. …”
Get full text

Influenza Surveillance in an Urban Area by W Paul Glezen

“…Young children would benefit from universal immunization with available live attenuated vaccines.…”
Get full text

Evaluating passive immunity in piglets from sows vaccinated with a PEDV S protein subunit vaccine by Jiajia Liu, Jiajia Liu, Guangli Hu, Shengjin Liu, Guangcai Ren, Liguo Gao, Liguo Gao, Zhiqing Zhao, Rui Geng, Dingli Wang, Xiao Shen, Feng Chen, Hanqin Shen, Hanqin Shen

“…Current control measures, such as inactivated and live-attenuated vaccines, have limitations in providing complete protection. …”
Get full text

Modern vaccines and coronavirus infections by Yu. A. Belikova, Yu. V. Samsonov, E. V. Abakushina

“…This review is on recent advances in the development of new generation vaccines, as well as those developed using earlier time-tested technologies: live attenuated vaccines, inactivated vaccines, recombinant vaccines, subunit vaccines, virus-like particle-based vaccines, synthetic peptide vaccines, DNA vaccines and mRNA vaccines. …”
Get full text

Multiple gene-deletion vaccinia virus Tiantan strain against mpox by Yilong Zhu, Dapeng Li, Renshuang Zhao, Minghua Chen, Yue Li, Xia Yang, Hongyue Mao, Xiao Li, Yiquan Li, Chao Shang, Xianzhu Xia

“…Collectively, these results demonstrate that TTVAC7 and TTVC5 may be used as potential live attenuated vaccines against MPXV infection.…”
Get full text

The <i>Meq</i> Genes of Nigerian Marek’s Disease Virus (MDV) Field Isolates Contain Mutations Common to Both European and US High Virulence Strains by Joseph N. Patria, Luka Jwander, Ifeoma Mbachu, Levi Parcells, Brian Ladman, Jakob Trimpert, Benedikt B. Kaufer, Phaedra Tavlarides-Hontz, Mark S. Parcells

“…Over the last 50 years, losses due to MDV infection have been controlled worldwide through vaccination; however, these live-attenuated vaccines are non-sterilizing and potentially contributed to the virulence evolution of MDV field strains. …”
Get full text

Safety of influenza vaccination during pregnancy: a systematic review by Brian Hutton, David Moher, Danielle B Rice, Claire Butler, Andrea C Tricco, Becky Skidmore, Candyce Hamel, Chantelle Garritty, Paul A Khan, Marco Ghassemi, Charlene Soobiah, Leila Esmaeilisaraji, Dianna M Wolfe, Deshayne Fell, Mona Hersi, Nadera Ahmadzai, Alan Michaud, Angela Sinilaite

“…Studies of live attenuated vaccines, single-arm cohort studies and abstract-only publications were excluded. …”
Get full text