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621
Risk factors and prognosis analysis of dysphagia after occipitocervical fusion surgery: a retrospective study of 43 cases
Published 2025-01-01“…Baseline data and imaging parameters were collected: O-C2 angle, C2-7 angle, pharyngeal inlet angle (PIA), posterior occipital cervical angle (POCA), O-EA angle, Oc-Ax angle, Atlas-dens interval, C2-7 sagittal vertical axis (SVA), T1 slope, narrowest oropharyngeal airway space (nPAS), and thickness of the prevertebral soft tissue. …”
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622
Association of tumour mutation burden with prognosis and its clinical significance in stage III gastric cancer
Published 2024-11-01“…Methods: Patients with stage III GC were divided into a high TMB and low TMB group in both a study cohort of 38 patients and the Cancer Genome Atlas (TCGA) cohort of 173 patients. In the study cohort, next-generation sequencing was used to detect mutated GC genes and obtain TMB data. …”
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623
MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma
Published 2025-01-01“…A survival analysis based on The Cancer Genome Atlas (TCGA) head and neck squamous cell carcinoma (HNSCC) dataset was performed to evaluate the correlation between MTMR6 expression and patient outcomes following cisplatin treatment. …”
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624
Brain radiotherapy and dorsal vagal complex irradiation: A new organ at risk to decrease radiation-induced nausea and vomiting?
Published 2025-03-01“…DVC delineation was performed on MRI T1 sequences with gadolinium injection using a reference atlas. Results: Among 102 patients, 68 were women, and median age was 61.5 years. …”
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625
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
Published 2022-03-01“…Both in-house tissue microarray and open accessed The Cancer Genome Atlas data sets were used to evaluate the clinical relevance in pancreatic cancer prognosis.Results LTX-315 treatment inhibited PD-L1 expression and enhanced lymphocyte infiltration in pancreatic tumors. …”
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626
Characterizing immune biomarkers and effector CD8+ T-cell exhaustion in pancreatic adenocarcinoma via single-cell RNA sequencing profiling
Published 2025-01-01“…We analyzed mutations in the shortlisted biomarkers from The Cancer Genome Atlas (TCGA) and performed in silico mutational analysis using Maestro to evaluate the impact of an IL7R mutation (K110N) on protein function. …”
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627
Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design
Published 2025-01-01“…Tissue enrichment of type 2 diabetes-associated genes on different genetic effect types was performed using publicly available gene expression data from the Human Protein Atlas database. We observed significant gene enrichment in paternal genetic nurture effects in the gallbladder, smooth muscle, and adrenal gland tissues. …”
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628
FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy
Published 2025-02-01“…Here we report that O-GlcNAcylation level is positively correlated with EC histologic grade in a Chinese cohort containing 219 tumors, validated in The Cancer Genome Atlas dataset. Increasing O-GlcNAcylation in patient-derived endometrial epithelial organoids promotes proliferation and stem-like cell properties, whereas decreasing O-GlcNAcylation limits the growth of endometrial cancer organoids. …”
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629
Novel pyroptosis-immune-related lncRNA signature exhibits a distinct immune cell infiltration landscape in breast cancer
Published 2025-01-01“…IntroductionThis study investigated pyroptosis- and immunity-related long non-coding RNAs (lncRNAs) to identify promising therapeutic targets for breast cancer (BC), and constructed lncRNA signatures to determine the prognosis and immunotherapy responses of BC patients.MethodsPearson’s correlation coefficient was used to identify pyroptosis- and immune-related differentially expressed lncRNAs (DE-pyrolncRNAs and DE-ImmlncRNAs, respectively). The Cancer Genome Atlas dataset was allocated to training and testing subsets. …”
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630
Insufficient gene expression and lost gene regulatory network may underlie the mechanism of Hirschsprung Disease in 5p–syndrome
Published 2025-02-01“…On the one hand, leveraging human single-cell atlas for developing enteric nervous system, we demonstrated that some affected genes in these two patients overlapped with those showing expression changes along the development pseudotime of enteric nervous cells (ENC) and overlapped with known HSCR genes including RET, NRG1, ERBB (ERBB2 and ERBB3), ITGB (ITGB1). …”
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631
QCD predictions for simultaneously produced Higgs and vector bosons at $$\sqrt{s}$$ s = 13, 14, 27 and 100 TeV with a comprehensive study of systematic uncertainty and charge asymm...
Published 2025-01-01“…Then, the threshold values (selection cuts) close to the values used by the CMS and ATLAS Collaborations were selected and used on several parameters such as invariant mass, transverse momentum ( $$p_{T}$$ p T ), pseudorapidity ( $$\eta $$ η ), etc. …”
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632
Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Progno...
Published 2024-12-01“…In order to understand specific factors associated with prognosis, we used the unsupervised clustering of an HPV-positive HNSCC cohort from The Cancer Genome Atlas (TCGA) (n = 53) based on HPV transcript expression, and identified four HPV-related subtypes (E2/E5, E6/E7, E1/E4 and L1/L2). …”
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633
Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma
Published 2025-01-01“…Methods Using data from The Cancer Genome Atlas Program (TCGA) as a training cohort and data from International cancer genome consortium (ICGC) as a testing cohort. …”
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634
Exploring the upper ocean characteristics of a bay using coastal and regional ocean community model
Published 2024-01-01“…During the simulation, there is a high correlation (0.96) between the evolution of the salinity and temperature values obtained from the model and the corresponding data from the World Ocean Atlas. This indicates a strong agreement between the model-based simulations and the assimilated data, as supported by the notable correlation values of 0.96 for salinity and temperature. …”
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635
Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma
Published 2022-01-01“…The mRNA transcriptome profiling data, somatic mutation data, and copy number gene level data of The Cancer Genome Atlas-Liver Hepatocellular Carcinoma project (TCGA-LIHC) were downloaded for subsequent analysis. …”
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636
Altered brain functional network connectivity and topology in type 2 diabetes mellitus
Published 2025-01-01“…Post-image preprocessing, brain functional networks were constructed using the Dosenbach atlas and analyzed with the DPABI-NET toolkit through graph theory.ResultsIn T2DM patients, functional connectivity within and between the default mode network (DMN), frontal parietal network (FPN), subcortical network (SCN), ventral attention network (VAN), somatosensory network (SMN), and visual network (VN) was significantly reduced compared to HCs. …”
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637
Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus
Published 2025-01-01“…Conclusions Our high-resolution single-cell atlas enhances the understanding of the immune and structural milieu of intestinal epithelium in lupus and provides new insights into lupus pathogenesis mediated by intestinal immune dysregulation.…”
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638
Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC
Published 2025-02-01“…BackgroundN6-methyladenosine (m6A) RNA modification is crucial for tumor development and progression; however, which m6A regulators play a pivotal role in head and neck squamous cell carcinoma (HNSCC) remains ambiguous.MethodsUtilizing the Cancer Genome Atlas (TCGA) database, the expression levels of m6A regulators in HNSCC were examined, which led to the identification of heterogeneous nuclear ribonucleoprotein C (HNRNPC) as a key gene. …”
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639
Using Statistical Analysis to Assess Urban Groundwater in Beni Mellal City (Morocco)
Published 2019-01-01“…The study was carried out in a shallow phreatic aquifer in the piedmont zone between the Atlas Mountains and Tadla plain in Morocco. This study is carried out using physicochemical analyses with statistical analysis (CA and PCA) to show variability of groundwater hydrochemical parameters beneath Beni Mellal city in order to know spatial variability of water quality under urban activities. …”
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640
DeepCERES: A deep learning method for cerebellar lobule segmentation using ultra-high resolution multimodal MRI
Published 2025-03-01“…We have also integrated deep learning with classical machine learning methods incorporating a priori knowledge from multi-atlas segmentation which improved precision and robustness. …”
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