CRISPR-Cas9 in Cardiovascular Medicine: Unlocking New Potential for Treatment by Klaudia Bonowicz, Dominika Jerka, Klaudia Piekarska, Janet Olagbaju, Laura Stapleton, Munirat Shobowale, Andrzej Bartosiński, Magdalena Łapot, Yidong Bai, Maciej Gagat

“…This article examines the potential of CRISPR-Cas9 in the treatment of various CVDs, including atherosclerosis, arrhythmias, cardiomyopathies, hypertension, and Duchenne muscular dystrophy (DMD). …”
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Clinical characteristics of patients with coronary artery disease by smoking status by Olga V. Nakhratova, Daria P. Tsygankova, Joseph M. Tsenter, Evgeny D. Bazdyrev

“…Percutaneous coronary interventions, history of acute cardiovascular events, arterial hypertension, multifocal atherosclerosis, and multivessel disease as defined by SYNTAX were more common in this group of patients. …”
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The relationship between oxLDL, sLOX-1, PCSK9 and carotid intima-media thickness in patients with prediabetes and type 2 diabetes by Zeki Dogan, Abdulhalim Senyigit, Sinem Durmus, Canan Duvarcı, Remise Gelişgen, Hafize Uzun, Omur Tabak

“…Abstract Affection of vascular structures is a known complication in diabetes and prediabetes. Subclinical atherosclerosis begins to develop years before both cardiovascular and cerebrovascular diseases become symptomatic. …”
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PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting by Izabela Wojtkowska, Tomasz A. Bonda, Andrzej Tysarowski, Katarzyna Seliga, Janusz A. Siedlecki, Maria M. Winnicka, Janina Stępińska

“…TNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). …”
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Development and Validation of a Predictive Model Based on Serum Silent Information Regulator 6 Levels in Chinese Older Adult Patients: Cross-Sectional Descriptive Study by Yuzi You, Wei Liang, Yajie Zhao

“…ObjectivesThis study developed a nomogram to demonstrate the functionality of SIRT6 in assessing severity of coronary artery atherosclerosis. MethodsPatients aged 60 years and older with angina pectoris were screened for this single-center clinical study between October 1, 2022, and March 31, 2023. …”
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Arbovirus exposure and subclinical myocardial dysfunction in an Indigenous population in Northeast Brazil: a cross-sectional study by Jandir Mendonça Nicacio, Carlos Dornels Freire de Souza, Ricardo Khouri, Vanessa Cardoso Pereira, Rodrigo Feliciano do Carmo, Pedro Vinícius Amorim de Medeiros Patriota, Sávio Luiz Pereira Nunes, Jeová Cordeiro de Morais Júnior, Manoel Barral-Netto, João Augusto Costa Lima, Anderson da Costa Armstrong

“…Methods This ancillary study is part of the first phase (2016–2017) of the Project of Atherosclerosis among Indigenous Populations (PAI), a cross-sectional study involving participants from two Indigenous communities with different degrees of urbanization and a highly urbanized city in Northeast Brazil. …”
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The role of adipose tissue cell elements in the regulation of the nitroxidergic system and possible ways of pharmacological modulation by I. F. Bielenichev, S. O. Maslennikov, N. V. Dobrelia, O. S. Khromov, M. L. Holovakha, V. P. Ryzhenko, O. O. Brek

“…This imbalance leads to vasoconstriction, leukocyte attachment and inflammatory reactions in the vascular wall, atherosclerosis and thrombosis. The aim: to evaluate the role of adipose tissue elements in the regulation of parameters of the nitroxidergic system under hypoxia conditions. …”
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Hubungan Berbagai Faktor Risiko Terhadap Kejadian Penyakit Jantung Koroner Pada Penderita Diabetes Melitus Tipe 2 by Fadma Yuliani, Fadil Oenzil, Detty Iryani

“…The mechanism of CHD in DM is associated with the presence of atherosclerosis that influenced by various factors. This research has aims to determine the relationship of risk factors for CHD incident in patients with DM. …”
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Antioxidant and cytotoxic activities of 2-oxo-1,2,3,4-tetrahydropyrimidines by Sarosh Iqbal, Shahida Perveen, M. Iqbal Choudhary, Musarrat Jabeen, Shumaila Kiran, Faiza Qayyum, Khalid Mohammed Khan

“…It contributes to the onset and progression of chronic inflammation, cancers, diabetes mellitus, atherosclerosis, Alzheimer’s disease, ocular disease, nephropathy, and premature aging. …”
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Flow Mediated Dilatation Is Reduced with the Progressive Stages of Glomerular Filtration Rate and Albuminuria in Type 2 Diabetic Patients without Coronary Heart Disease by Hiroyuki Ito, Mina Nakashima, Kentaro Meguro, Haruki Furukawa, Hitomi Yamashita, Akifusa Takaki, Chizuko Yukawa, Takashi Omoto, Masahiro Shinozaki, Shinya Nishio, Mariko Abe, Shinichi Antoku, Mizuo Mifune, Michiko Togane

“…In conclusion, the FMD is considered to be useful for the detection of atherosclerosis in patients with type 2 diabetes, even if overt macroangiopathy is not diagnosed.…”
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Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

“…CD36 overexpression favors progression of different pathologies, such as atherosclerosis and cancer. Thus, CD36 targeting has medicinal relevance. …”
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Factors Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus by Bin-Bin He, Li Wei, Yun-Juan Gu, Jun-Feng Han, Ming Li, Yu-Xiang Liu, Yu-Qian Bao, Wei-Ping Jia

“…Positive correlations were found between DR and duration of diabetes, systolic blood pressure (SBP), diastolic blood pressure, glycated hemoglobin, glycated albumin, 24 hurinary albumin excretion, peripheral atherosclerosis (PA), diabetes nephropathy (DN), diabetic peripheral neuropathy, and anemia. …”
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Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status by Nelo Eidy Zanchi, Felipe Natali Almeida, Fábio Santos Lira, José César Rosa Neto, Humberto Nicastro, Claudia Ribeiro da Luz, Mário Alves de Siqueira Filho, Vitor Felitti, Mariz Vainzof, Marilia Seelaender, Jacques R. Poortmans, Antonio Herbert Lancha

“…Physical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. …”
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Clinical and anamnestic characteristics of patients with clinical manifestations of peripheral artery disease as a function of Т(–786)С polymorphism of the endothelial NO-synthase... by V.I. Tseluyko, L.M. Yakovleva, O.D. Yarova

“…The aim – to determine the prevalence of Т(–786)С polymorphic gene variants of endothelial NO-synthase (eNOs) in patients with verified atherosclerosis of lower extremities arteries and their association with clinical manifestations of the disease. …”
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Vaping – A Beneficial Alternative to Traditional Cigarettes or an Unexplored Danger? by Paulina Błasiak, Aleksandra Ślusarska, Patryk Mikołajec, Barbara Bilecka, Jolanta Mędyk, Małgorzata Wirkijowska, Jakub Wirkijowski, Yauheniya Patarocha, Michał Rogulski, Ruslan Huk

“…Studies suggest that long-term e-cigarette use may result in increased aortic stiffness, elevated heart rate, heightened risk of atherosclerosis and diminished lung function, increased airway resistance, especially in individuals with pre-existing conditions like asthma. …”
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Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes by Yongpisarn T, Thadanipon K, Suchonwanit P, Rattanakaemakorn P

“…Research suggests that psoriasis-induced inflammation can trigger insulin resistance and high blood sugar (hyperglycemia), which in turn triggers abnormal functioning of the blood vessel’s inner lining, ultimately leading to atherosclerosis and cardiovascular disease. Interestingly, insulin resistance may also worsen psoriatic skin lesions. …”
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Immunomodulatory Effects of Aerobic Training in Obesity by Thomas Nickel, Henner Hanssen, Ingrid Emslander, Verena Drexel, Gernot Hertel, Arno Schmidt-Trucksäss, Claudia Summo, Zeljka Sisic, Marius Lambert, Eva Hoster, Martin Halle, Michael Weis

“…Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. …”
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Dyslipidemia and metabolic syndrome in childhood-onset systemic lupus erythematosus: is it time to screen? by Sirin Nuntasri, Sirirat Charuvanij, Kraisoon Lomjansook, Puthita Saengpanit, Kwanjai Chotipanang, Maynart Sukharomana

“…Dyslipidemia and metabolic syndrome are recognized risk factors for premature atherosclerosis. This study aimed to determine the prevalence of dyslipidemia and metabolic syndrome, and to explore the relationships between lipid profiles, anthropometry, and disease status in cSLE. …”
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Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome by Hamad Al Shahi, Kazunori Shimada, Katsumi Miyauchi, Takuma Yoshihara, Eiryu Sai, Tomoyuki Shiozawa, Ryo Naito, Tatsuro Aikawa, Shohei Ouchi, Tomoyasu Kadoguchi, Tetsuro Miyazaki, Hiroyuki Daida

“…Circulating levels of pro-/anti-inflammatory cytokines, including IL-23A, IL-27, IL-33, and IL-37, may be associated with the pathogenesis of atherosclerosis in ACS patients.…”
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Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated P... by Katarina Lalić, Aleksandra Jotić, Nataša Rajković, Sandra Singh, Ljubica Stošić, Ljiljana Popović, Ljiljana Lukić, Tanja Miličić, Jelena P. Seferović, Marija Maćešić, Jelena Stanarčić, Milorad Čivčić, Iva Kadić, Nebojša M. Lalić

“…The altered diurnal fluctuation of PAI-1, especially in T2D with CAD, might be strongly influenced by a prolonged exposure to hyperinsulinemia in the settings of increased IR and abdominal obesity, facilitating altogether an accelerated atherosclerosis.…”
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