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281
Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease
Published 2013-01-01“…The pathophysiology of coronary artery disease in obstructive sleep apnea patients probably includes the activation of multiple mechanisms, as the sympathetic activity, endothelial dysfunction, atherosclerosis, and systemic hypertension. Moreover, chronic intermittent hypoxia and oxidative stress have an important role in the pathogenesis of coronary disease and are also fundamental to the development of atherosclerosis and other comorbidities present in coronary artery diseases such as lipid metabolic disorders. …”
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282
Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
Published 2005-01-01“…Thus, in POC, positively interrelated to each other, elevated CRP and unaltered SAA levels reveal a unique profile of the CLGSI, not explaining homocysteinemia-induced risk for future atherosclerosis.…”
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283
Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacol...
Published 2024-11-01“…Valvular diseases, atherosclerosis, and cardiac arrhythmias are prevalent, with immune complex deposition playing a role in atherosclerosis. …”
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284
CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway
Published 2020-01-01“…Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. …”
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285
COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study
Published 2008-01-01“…Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the −765G→C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level. …”
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286
The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications
Published 2017-01-01“…This review discussed specifically the role of IR isoforms as well as IGF-IR in diabetes and its associated complications as obesity and atherosclerosis. Future research with new IR modulators might be considered as possible targets to improve the treatment of diabetes and its associated complications.…”
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287
Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta-Analysis
Published 2022-01-01“…Children with the rs266729 variant had a high risk to develop dyslipidemia, atherosclerosis, and even early onset of CAD in the future. …”
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288
Advancing Insights into Large-Artery Stiffening in Humans Through the Application of Multi-omics
Published 2024-07-01“…Importantly, LAS is pathologically different from atherosclerosis as it rather occurs primarily from changes in the medial aortic layer, and can manifest itself in the absence of plaque formation. …”
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289
Ataxin-10 Inhibits TNF-α-Induced Endothelial Inflammation via Suppressing Interferon Regulatory Factor-1
Published 2021-01-01“…Endothelial inflammation is a crucial event in the initiation of atherosclerosis. Here, we identify Ataxin-10 protein as a novel negative modulator of endothelial activation by suppressing IRF-1 transcription activity. …”
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290
Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare
Published 2009-01-01“…Systemic vasculitis relapses are followed to accelerated atherosclerosis: severe ischemic lesions led to amputation of lower limbs. …”
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291
Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State
Published 2015-01-01“…Inflammatory processes are involved in atherosclerosis development. Macrophages play a major role in the early atherogenesis, and they are present in the atherosclerotic lesion in two phenotypes: proinflammatory (M1) or anti-inflammatory (M2). …”
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292
Relation of Asymmetric Dimethylarginine Levels to Macrovascular Disease and Inflammation Markers in Type 2 Diabetic Patients
Published 2014-01-01“…We recruited 50 type 2 diabetic patients with atherosclerosis, 50 type 2 diabetic patients without atherosclerosis, and 31 healthy control patients into our study. …”
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293
Impact of Diabetes on Cardiovascular Disease: An Update
Published 2013-01-01“…The proposed mechanisms that can link accelerated atherosclerosis and increased cardiovascular risk in this population are poorly understood. …”
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294
Role of Rutin on Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells
Published 2014-01-01“…Oxidative stress plays an important role in the pathogenesis of various cardiovascular diseases, including atherosclerosis. Decreased availability of endothelial NO promotes the progression of endothelial dysfunction and atherosclerosis. …”
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295
Does structural compromise of the aorta in patients with aortic pathologies predict increased spinal and vascular complications and reoperations in patients undergoing anterior app...
Published 2024-12-01“…Previous reports have detailed vascular injuries during exposure/approach; however, it is not well-documented whether structural aortic pathology, such as aneurysm, dissection, atherosclerosis, aortitis, or aortic tumors, impacts postoperative outcomes following anterior approach to the spine for spinal fusion. …”
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296
Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes
Published 2013-01-01“…CD4+LAP+ Treg cells are a novel subset of Tregs that have been found to ameliorate atherosclerosis in ApoE-/- mice, and these cells also exist in humans. …”
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297
Atherogenic Risk Factors in Medical Students
Published 2020-12-01“…<strong>Background:</strong> atherosclerosis is a multifactorial origin disease. The study and approach of its modifiable risk factors and action on these factors can positively change the health situation. …”
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298
Pengaruh Lama Pemberian Diet Tinggi Kolesterol terhadap Kadar LDL dan TGF-Β Serum Tikus Putih (Rattus novergicus) strain Wistar
Published 2016-01-01“…</em></p><p><strong>Kata kunci:</strong> diet tinggi kolesterol, LDL<em>,</em> TGF-β</p><p><strong><em> </em></strong></p><p><strong><em>Abstract</em></strong></p><p><em>High-cholesterol diet will increase </em><em>Low Density Lipoprotein</em><em> </em><em>(LDL) levels which impact to atherosclerosis. </em><em>Transforming Growth Factor β (</em><em>TGF-β) play a role in atherosclerosis process. …”
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299
The Level of hs-CRP in Coronary Artery Ectasia and Its Response to Statin and Angiotensin-Converting Enzyme Inhibitor Treatment
Published 2007-01-01“…The anti-inflammatory effects of statins and the effect of angiotensin-converting enzyme (ACE) inhibitors on endothelial dysfunction are well established in atherosclerosis. The aim of the present study was to investigate CRP level and its response to statin and ACE inhibitor treatment in CAE. …”
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300
Identification of key genes associated with oxidative stress in ischemic stroke via bioinformatics integrated analysis
Published 2025-01-01“…Although the formation of atherosclerosis, which is closely related to oxidative stress (OS), is associated with stroke-related deaths. …”
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