Folate Receptor–Targeted Single-Photon Emission Computed Tomography/Computed Tomography to Detect Activated Macrophages in Atherosclerosis: Can It Distinguish Vulnerable from Stable Atherosclerotic Plaques? by Leah C.J. Winkel, Harald C. Groen, Bibi S. van Thiel, Cristina Müller, Antonius F.W. van der Steen, Jolanda J. Wentzel, Marion de Jong, Kim Van der Heiden

“…Activated macrophages play a role in atherosclerosis and express folate receptor folate receptor β (FR-β). …”
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Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice by Ying Huang, Haiying Hu, Ling Liu, Jing Ye, Zhen Wang, Bin Que, Wenjing Liu, Ying Shi, Tao Zeng, Lei Shi, Qingwei Ji, Chao Chang, Yingzhong Lin

“…Additionally, exogenous rIL-35 treatment reversed the imbalance of Th17/Treg and attenuated atherosclerosis in ApoE-/- mice. These findings suggest that IL-12p35 deficiency ameliorates atherosclerosis in ApoE-/- mice, partially, via attenuating the Th1/Th2 imbalance, although IL-12p35 deficiency aggravates the Th17/Treg imbalance.…”
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Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors by Agata Stanek, Armand Cholewka, Tomasz Wielkoszyński, Ewa Romuk, Aleksander Sieroń

“…WBC appears to be a useful method of atherosclerosis prevention in AS patients.…”
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Positive Islet Cell Cytoplasmic Antibody and Long-Term Use of Lipid-Lowering Agents Are Positively Correlated With Peripheral Atherosclerosis in Patients With Autoimmune Diabetes: A Cross-Sectional Study by Xinyue Chen, Jie Yu, Yiwen Liu, Xuechen Wang, Fan Ping, Wei Li, Huabing Zhang, Lingling Xu, Yuxiu Li

“…Conclusions: The correlation between positive ICA and atherosclerosis suggests inflammation at an early stage plays a role in macrovascular complications in autoimmune diabetes. …”
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most m6A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m6A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m6A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m6A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m6A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m6A-RMRs the most among viral infections; (6) proinflammatory oxPAPC modulated m6A-RMRs more than DAMP stimulation including LPS and oxLDL; (7) upregulated m6A-RMRs were more than downregulated m6A-RMRs in cancer types; five types of cancers upregulated ≥10 m6A-RMRs; (8) proinflammatory M1 macrophages upregulated seven m6A-RMRs; (9) 86% of m6A-RMRs were differentially expressed in the six clusters of CD4+Foxp3+ immunosuppressive Treg, and 8 out of 12 Treg signatures regulated m6A-RMRs; (10) immune checkpoint receptors TIM3, TIGIT, PD-L2, and CTLA4 modulated m6A-RMRs, and inhibition of CD40 upregulated m6A-RMRs; (11) cytokines and interferons modulated m6A-RMRs; (12) NF-κB and JAK/STAT pathways upregulated more than downregulated m6A-RMRs whereas TP53, PTEN, and APC did the opposite; (13) methionine-homocysteine-methyl cycle enzyme Mthfd1 downregulated more than upregulated m6A-RMRs; (14) m6A writer RBM15 and one m6A eraser FTO, H3K4 methyltransferase MLL1, and DNA methyltransferase, DNMT1, regulated m6A-RMRs; and (15) 40 out of 165 ROS regulators were modulated by m6A eraser FTO and two m6A writers METTL3 and WTAP. …”
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Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant Celiac Disease: A Case-Control Study by Maryam Alaei, Mohamad Ghazanfari Hashemi, Seyedeh Nooshin Miratashi Yazdi, Mohammad Ali Kaviani, Ali Asadifar, Sahand Adib Moradi, Khazar Adibmoradi Langaroudi, Helia Helali, Mina Mahboudi, Aynaz Gerami

“… Purpose: Intima-Media Thickness (IMT), which is frequently evaluated by B-mode ultrasound study, has been proved to be a reliable surrogate marker for atherosclerosis progression and a predictor of upcoming cardiovascular risks. …”
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Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization by Libo Liu, Ziyu An, Huan Zhang, Xueqi Wan, Xin Zhao, Xueyao Yang, Jinfan Tian, Xiantao Song

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Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project by Daniel Bia, Yanina Zócalo, Ignacio Farro, Juan Torrado, Federico Farro, Lucía Florio, Alicia Olascoaga, Javier Brum, Walter Alallón, Carlos Negreira, Ricardo Lluberas, Ricardo L. Armentano

“…Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. …”
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ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study by Malin Mickelsson, Kim Ekblom, Kristina Stefansson, Per Liv, Anders Själander, Ulf Näslund, Johan Hultdin

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Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases by Vidyashree, Lakshmi D, Prashanth D, Indushree T, Hamsaveena

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Monocyte to High‐Density Lipoprotein Ratio Is Associated With Carotid Plaque: A Retrospective Cohort Study by Shuang Liu, Xinlei Miao, Manling Hu, Ziping Song, Xiaoling Xie, Yuting Sun, Meng Li, Guimin Tang, Song Leng

Subjects: “…atherosclerosis…”
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Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States by Hao Deng, Mengmeng Sun, Zhentong Zhao, Kun Fan, Zizhang Zhao, Yifan Chi, Wei Sheng

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Coronary plaque characteristics quantified by artificial intelligence-enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population by Guadalupe Flores Tomasino, Caroline Park, Kajetan Grodecki, Jolien Geers, Donghee Han, Andrew Lin, Keiichiro Kuronuma, Nipun Manral, Emily Xing, Heidi Gransar, Sebastien Cadet, Alan Rozanski, Piotr J. Slomka, Michelle Williams, Daniel S. Berman, Damini Dey

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Mycoplasma pneumoniae drives macrophage lipid uptake via GlpD-mediated oxidation, facilitating foam cell formation by Takeshi Yamamoto, Miki Okuno, Koichi Kuwano, Yoshitoshi Ogura

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Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia by Fouzul Kansul, Deborah Vela, MD, Judit Csore, MD, Bright Benfor, MD, Sasha Suarez, MD, Anahita Dua, MD, MBA, MSC, Trisha L. Roy, MD, PhD

Subjects: “…Atherosclerosis…”
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Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade by Nicholas H. Adamstein, MD, Jean G. MacFadyen, BA, Brittany N. Weber, MD, PhD, Peter Libby, MD, Daniel H. Solomon, MD, MPH, Paul M Ridker, MD, MPH

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Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion by Lu Wang, Jia-Qi Ma, Li-Jia Song, Xiao-Peng Qu, Yue Zhang, Hai-Ming Fan, Chao Wang, Long-Long Zheng, Guo-Dong Gao, Yan Qu, Liang-Liang Shen, Bei Liu

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First‐in‐Man Study of a Novel Peripheral Plaque Atherectomy Device by Hui Wang, Dikang Pan, Shijun Cui, Zhu Tong, Xixiang Gao, Yongquan Gu, Jianming Guo, Lianrui Guo

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Recommendations for the primary prevention of atherosclerotic cardiovascular disease in primary care: a systematic guideline review by Maren Bredehorst, Ana I. González-González, Lara Schürmann, Dennis Firmansyah, Christiane Muth, Jörg Haasenritter, Veronika van der Wardt, Svetlana Puzhko

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Menopausal Hormone Therapy: Its Role in the Prevention of Cardiovascular Diseases and the Risk of Breast Cancer in Women by Tam Thai Thanh Tran, Thu Minh Phung, Anh Thi Mai Do, Quynh Tran Mai Ly, Tin Hoang Nguyen

Subjects: “…atherosclerosis…”
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