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The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase
Published 2020-01-01“…Hypercholesterolemia- (HC-) induced endothelial dysfunction is the first step of atherogenesis, and the peroxisome proliferator-activated receptor γ (PPARγ) has been reported to attenuate atherosclerosis formation; however, the underlying mechanisms are not fully understood. …”
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42
Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis
Published 2015-01-01“…Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis. In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according to established morphological criteria. …”
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43
Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits
Published 2012-01-01“…Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms.…”
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44
Systemic Lupus Erythematosus, Its Impact on Selected Cardiovascular Risk Factors, and Correlation with Duration of Illness: A Pilot Study
Published 2020-01-01“…It leads to an increased production of proinflammatory molecules that accelerates atherogenesis and could cause an endothelium dysfunction. …”
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45
Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment
Published 2019-01-01“…Many studies highlighted its role in the development of cardiac fibrosis or atherogenesis, being significantly correlated with the activity of angiotensin II. …”
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RELATIONSHIPS BETWEEN LIPID PROFILE AND COMPLETE BLOOD CELL COUNT PARAMETERS
Published 2022-12-01“…Given that blood cells play an important role in both atherogenesis and lipid metabolism, the research aimed to assess the specifics of the relationship between the parameters of the blood lipid spectrum and the complete blood count (CBC). …”
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Oxidative impact on lipoprotein structure: Insights from dynamic light scattering
Published 2025-03-01“…Lipoproteins, key biomolecules in lipid transport, are particularly susceptible to oxidative modifications, which can contribute to atherogenesis. The need for advanced analytical tools to better understand the pathogenesis of cardiovascular disease (CVD) is critical due to its significant impact on public health. …”
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Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome
Published 2006-01-01“…IgG anti-2GPI−oxLig-1 may be involved in PAPS related atherogenesis via decreased PON activity.…”
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Lipoprotein (a) levels in children with heterozygous familial hypercholesterolemia
Published 2024-12-01“…BACKGROUND: Recent studies show that lipoprotein (a), or Lp(a), plays a specific role in the development of atherosclerosis. Lp(a) promotes atherogenesis by increasing production of pro-inflammatory cytokines and depositing on the arterial wall. …”
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The Effects of Statin Dose, Lipophilicity, and Combination of Statins plus Ezetimibe on Circulating Oxidized Low-Density Lipoprotein Levels: A Systematic Review and Meta-Analysis o...
Published 2021-01-01“…Oxidative modification of LDL (ox-LDL) is considered to be the most important atherogenic modification of LDL and is supposed to play a crucial role in atherogenesis and ASCVD outcomes. Objective. The aim of this systematic review and meta-analysis was to find out what are the effects of statin intensity, lipophilicity, and combination of statins plus ezetimibe on ox-LDL. …”
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MSCs Contribute to the Conversion of Ly6Chigh Monocytes into Ly6Clow Subsets under AMI
Published 2020-01-01“…NR4A1 is a novel target for modulating the inflammatory phenotype of monocytes during atherogenesis. Objectives. We aimed to investigate whether MSCs can contribute to the heterogeneity of Ly6Chigh monocytes differentiated into Ly6Clow monocytes and whether this regulation is related to nuclear receptor NR4A1. …”
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