Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact? by Gowri Subbiah, Anushiya Periyannan, Poongodi Lakshmi Santhanakumarasamy, Surendar Subramanian, Sumathi Ramalingam

“…Background: Chronic persistent inflammation associated with Helicobacter pylori (H. pylori) infection accelerates vascular complications which are prone to cause atherogenesis and coronary artery disease (CAD). This study was undertaken to assess the significance of the association between H. pylori immunoglobulin G (IgG) serostatus and the occurrence of CAD among hypertensives. …”
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Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis by Despina Giakomidi, Despina Giakomidi, Ayoola Ishola, Meritxell Nus, Meritxell Nus

“…Whilst existing research extensively explores the impact of the microbiome on the innate immune system, only a handful of studies have explored the regulatory capacity of the microbiome on the adaptive immune system to modulate atherogenesis. Building on these concepts and the pitfalls on the gut microbiota and adaptive immune response interaction, this review explores potential strategies to therapeutically target the microbiome, including the use of prebiotics and vaccinations, which could influence the adaptive immune response and consequently plaque composition and development.…”
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Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages by A. Ocaña, G. Reglero

“…As a cellular model of inflammation/atherogenesis, we use human macrophages derived from THP-1 monocytes and activated by oxidized LDLs. …”
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Hypoglycaemic, anti-hyperlipidemic, and anti-inflammatory activities of Asparagus africanus (Asparaceae) extract on high-fat diet/streptozotocin-induced diabetes in Wistar rats by Focham Evans Ngwenah, Oumar Mahamat, Tume Christopher

“…It has the potential to reduce the glucose level and the risk of inflammation and atherogenesis in diabetic patients.…”
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Effect of Vitamins A, C, and E Supplementation in the Treatment of Metabolic Syndrome in Albino Rats by L. S. Bilbis, S. A. Muhammad, Y. Saidu, Y. Adamu

“…The percentage protection of the supplemented groups against atherogenesis indicated 55.50±3.75%. Percentage weight gain indicated significant positive correlation with triglyceride, insulin resistance, and malondialdehyde while total antioxidant status and nitric oxide showed significant negative correlation. …”
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The role of adhesion molecules in inflammatory bowel disease in children. Assessment of the possible risk of cardiovascular complications by Aneta Trzeciak-Jędrzejczyk, Ryszard Makosiej, Michał Kolejwa, Ewa Głowacka, Elżbieta Czkwianianc

“…The same adhesion molecules play an important role in atherogenesis. Aim : To assess the risk of atherosclerosis in IBD in children. …”
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Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel F-Folate Radiotracer by Adrienne Müller, Katharina Beck, Zoran Rancic, Cristina Müller, Cindy R. Fischer, Thomas Betzel, Philipp A. Kaufmann, Roger Schibli, Stefanie D. Kramer, Simon M. Ametamey

“…A pivotal step in atherogenesis is the subendothelial accumulation of macrophages. …”
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Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract by Soundararajan Kamalakkannan, Ramaswamy Rajendran, Ramasamy V. Venkatesh, Paul Clayton, Mohammad A. Akbarsha

“…CFE treatment also conferred protection against atherogenesis. We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties.…”
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Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis by Moritz Lehners, Hannes Schmidt, Maria T. K. Zaldivia, Daniel Stehle, Michael Krämer, Andreas Peter, Julia Adler, Robert Lukowski, Susanne Feil, Robert Feil

“…Correlative profiling of pathway activity and VSMC phenotype at the single-cell level shows that phenotypic modulation of contractile VSMCs to chondrocyte-like plaque cells during atherogenesis is associated with a switch from ANP/GC‑A to CNP/GC‑B signaling. …”
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Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit by Maohua Cao, Junaid A. Khan, Bum-Yong Kang, Jawahar L. Mehta, Paul L. Hermonat

“…Compared to control Neo gene-treated animals, individual hSTAT3 and hIL-10 delivery resulted in significant reduction in atherogenesis, as determined by larger aortic lumen size, thinner aortic wall thickness, and lower blood velocity (all statistically significant). …”
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Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State by Marie Koren-Gluzer, Mira Rosenblat, Tony Hayek

“…Macrophages play a major role in the early atherogenesis, and they are present in the atherosclerotic lesion in two phenotypes: proinflammatory (M1) or anti-inflammatory (M2). …”
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LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling by Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xie

“…In summary, MDRL alleviates NLRP3 inflammasome activation and apoptosis in VSMCs through miR-361/SQSTM1/NLRP3 pathway during atherogenesis. These data indicate that MDRL and inhibition of miR-361 represent potential therapeutic targets in atherosclerosis-related diseases.…”
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Impact of Laparoscopic Sleeve Gastrectomy on Thrombomodulin Concentration and Early Markers of Atherosclerosis by Hasan Elkan, Mehmet Memduh Baş, Berna Kaya

“…LSG might prevent or reduce atherogenesis in the early stages by stopping endothelial dysfunction.…”
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Prevalence of Metabolic Syndrome in Patients with Psoriasis by Ilkin Zindancı, Ozlem Albayrak, Mukaddes Kavala, Emek Kocaturk, Burce Can, Sibel Sudogan, Melek Koç

“…It is thought that chronic inflammation results in metabolic diseases and proinflammatory cytokines give rise to the development of atherogenesis, peripheral insulin resistance, hypertension, and type 2 diabetes. …”
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Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice. by Avigail Ehrlich, Graziano Pelli, Bernard Foglia, Filippo Molica, Brenda R Kwak

“…The lymphatic system ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells to draining lymph nodes, thereby potentially affecting atherogenesis. Endothelial cell-specific deletion of Pannexin1 (Panx1) in apolipoprotein E-deficient (Apoe-/-) mice increased atherosclerosis, suggesting a protective role for Panx1 channels in arterial endothelial function. …”
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Effectiveness of heat source/sink and Lorentz force constraints in a non-Newtonian peristaltic arterial blood hybrid nanofluid past an overlapping stenotic artery by Vedhesh Dhinakaran, Keerthi Devarajan Anuradha, J.U. Viharika, Umair Khan, Nermeen Abdullah, Samia Elattar

“…This causes cardiovascular diseases like atherosclerosis, atherogenesis, atheroma, etc. Considering this the present research paper develops a Casson fluid model to investigate magnetohydrodynamic peristaltic transport of the passage of blood through slightly stenosed arteries due to the influence of copper (Cu) and alumina (Al2O3) nanoparticles. …”
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Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis by Luis Rodríguez-Rodríguez, Raquel López-Mejías, Mercedes García-Bermúdez, Carlos González-Juanatey, Miguel A. González-Gay, Javier Martín

“…Besides traditional CV risk factors and chronic inflammation, a number of studies have confirmed the role of genetic factors in the development of the atherogenesis observed in RA. In this regard, besides a strong association between the HLA-DRB1*04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G>A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A>C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA. …”
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The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts by Giuseppe Maiolino, Giacomo Rossitto, Paola Caielli, Valeria Bisogni, Gian Paolo Rossi, Lorenzo A. Calò

“…This review examines the role played by oxidized LDLs in atherogenesis taking into account data derived by studies based on molecular and clinical approaches. …”
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Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside by Wende Tian, Jianqing Ju, Baoyi Guan, Tongxin Wang, Jiqian Zhang, Luxia Song, Hao Xu

“…Despite increasing recognition of its role in atherogenesis, the precise mechanisms and clinical implications of HHcy remain incompletely understood, necessitating a comprehensive review to connect recent mechanistic insights with practical applications.Methods We analyzed the various mechanisms whereby HHcy accelerates the progression of atherosclerosis, and conducted a comprehensive review of publications in the fields of HHcy and atherosclerosis.Results HHcy promotes atherosclerosis through several mechanisms, including inflammation, oxidative stress, epigenetic modification, and lipoprotein metabolism alteration. …”
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Understanding the Relationship Between Cerebrovascular Disease and the Gut Microbiome by William Roth, Elaine Lo, Orlando De Leon, Sajid Suriya, Farima Fakhri, James R. Brorson, Sean Polster, Tareq Kass‐Hout, Shyam Prabhakaran, James E. Siegler

“…Moreover, the metabolism of certain substrates found in animal products (notably l‐carnitine and choline) and of refined sugars by these microorganisms leads to buildup of circulating metabolites with known links to atherogenesis, platelet activation, atrial fibrillation, and other adverse vascular outcomes. …”
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