PET Study in a Patient with Spinocerebellar Degeneration before and after Long-Term Administration of Thyrotropin Releasing Hormone by H. Tanji, H. Nagasawa, T. Hayashi, H. Onodera, T. Fujiwara, M. Itoh, T. Ido, Y. Itoyama

“…A 56-year-old female, who had suffered from progressive ataxia for 2 years, was treated by intravenous administration of 2 mg TRH for 3 weeks, and CMRG1c of the brain was measured before and after treatment. …”
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“Dancing Eye Syndrome” Secondary to Opsoclonus-Myoclonus Syndrome in Small-Cell Lung Cancer by S. Laroumagne, Xavier Elharrar, B. Coiffard, J. Plojoux, H. Dutau, D. Breen, P. Astoul

“…Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called “dancing eye syndrome,” is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cell-surface antigens have been reported, usually most patients are serum antibody negative. …”
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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…Progressive neurological deterioration and insurgence of symptoms like ataxia, seizure, and cognitive decline until severe dementia are pathognomonic features of the disease. …”
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Neuroophthalmic Manifestations of Intracranial Tumours in Children by Megha Kotecha, Sarang Gotecha, Ashish Chugh, Prashant Punia

“…Neurological manifestations of seizures, altered sensorium and motor deficits were more frequently seen in supratentorial tumours, while cranial nerve involvement and ataxia were seen in infratentorial tumours. Ophthalmological manifestations including diplopia, strabismus, ophthalmoparesis, and nystagmus were more frequently seen in infratentorial tumours. …”
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Challenges in Diagnosis and Management of Altered Mental Status in the Setting of Urosepsis and Hydrocephalus Secondary to an Occlusive Cyst of the Fourth Ventricle: A Case Report by Matthew Van Ligten, Miles Hudson, Jonathon J. Parker, Wayne A. Martini

“…The patient’s symptoms, including confusion, urinary dysfunction, and gait ataxia, initially masked the hydrocephalus, emphasizing the importance of considering this condition in patients with prolonged progression of neurological deficits. …”
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Identifying unstable CNG repeat loci in the human genome: a heuristic approach and implications for neurological disorders by Varun Suroliya, Bharathram Uppili, Manish Kumar, Vineet Jha, Achal K. Srivastava, Mohammed Faruq

“…In this study, we aimed to identify novel unstable CNG repeat loci associated with the neurogenetic disorder spinocerebellar ataxia (SCA). Using a computational approach, 15,069 CNG repeat loci in the coding and noncoding regions of the human genome were identified. …”
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Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report by Zhengping Cheng, Yang Song, Shuqi Zhao, Xiaowen Sui, Lili Xie, Hongling Zhao, Xin Pan, Li Cui, Xinran Huang, Shubei Ma

“…Abstract Background Autoimmune encephalitis associated with anti-GluK2 antibodies is a recently identified condition, typically characterized by cerebellar ataxia. This case report presents a unique clinical manifestation involving involuntary movements and emotional dysregulation, expanding the known phenotype spectrum. …”
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HIV-Associated Vacuolar Myelopathy and HIV-Associated Dementia as the Initial Manifestation of HIV/AIDS by Natalia Wuliji, Matthew J. Mandell, Jason M. Lunt, Adam Merando

“…HIV-VM causes progressive spastic paraparesis, sensory ataxia, and autonomic dysfunction. It is a progressive myelopathy that shares features with subacute combined degeneration seen in vitamin B12 deficiency as well as other neurological diseases and can occur synchronously with HIV-associated dementia (HAD). …”
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Restoration of Central Programmed Movement Pattern by Temporal Electrical Stimulation-Assisted Training in Patients with Spinal Cerebellar Atrophy by Ying-Zu Huang, Yao-Shun Chang, Miao-Ju Hsu, Alice M. K. Wong, Ya-Ju Chang

“…Since peripheral electrical stimulation (ES) and motor training may modulate motor cortical excitability through plasticity mechanisms, we aimed to investigate whether temporal ES-assisted movement training could influence premovement cortical excitability and alleviate hypermetria in patients with spinal cerebellar ataxia (SCA). The EMG of the agonist extensor carpi radialis muscle and antagonist flexor carpi radialis muscle, premovement motor evoked potentials (MEPs) of the flexor carpi radialis muscle, and the constant and variable errors of movements were assessed before and after 4 weeks of ES-assisted fast goal-directed wrist extension training in the training group and of general health education in the control group. …”
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DISTURBIOS PRAXICOS EN LESIONES FOCALES DE LOS HEMISFERIOS CEREBRALES by Jorge Murillo Duran

“…De acuerdo con la literatura sobre la materia, se ha aceptado la definición de la apraxia como la inhabilidad en ejecutar correctamente tareas cinéticas, sin la debilitación o la pérdida de motricidad o de funciones sensoriales o la ataxia como condicionante de tal inhabilidad". …”
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Primary hyperparathyroidism presenting as acute hypercalcemic crisis: a case report by Gia Gill, Veena Agrawal, Paul Kerr

“…Case presentation A 60-year-old male presented to hospital with sudden onset of confusion, muscle weakness, and ataxia. Initial labs showed serum calcium 4.79 mmol/L, parathyroid hormone 2043 ng/L; creatinine 364 μmol/L. …”
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Comparative (Computational) Analysis of the DNA Methylation Status of Trinucleotide Repeat Expansion Diseases by Mohammadmersad Ghorbani, Simon J. E. Taylor, Mark A. Pook, Annette Payne

“…We have combined this data and used a pattern searching algorithm to identify motifs in the DNA surrounding aberrantly methylated CpGs found in the DNA of patients with one of the three trinucleotide repeat (TNR) expansion diseases: fragile X syndrome (FRAXA), myotonic dystrophy type I (DM1), or Friedreich’s ataxia (FRDA). We examined sequences surrounding both the variably methylated (VM) CpGs, which are hypermethylated in patients compared with unaffected controls, and the nonvariably methylated CpGs which remain either always methylated (AM) or never methylated (NM) in both patients and controls. …”
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Increase of nitrous oxide-induced neurological disorders – a German multicenter experience by Julius Nicolai Meißner, Janina Neuneier, Iason Bartzokis, Mathias Rehm, Ahmad Al-Hayali, Marcus Müller, Sebastian Paus, Volker Limmroth, Gereon R. Fink, Gabor C. Petzold, Louisa Nitsch

“…The most common symptoms were sensory loss, ataxia, and motor deficits. Conclusion Our data suggest that N₂O abuse is on the rise in Germany. …”
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Human lineage mutations regulate RNA-protein binding of conserved genes NTRK2 and ITPR1 involved in human evolution by Min Zhao, Weichen Song, Shunying Yu, Wenxiang Cai, Guan Ning Lin

“…These genes also carried excess damaging coding mutations that caused neurodevelopmental disorders, ataxia and schizophrenia. Among these genes, NTRK2 and ITPR1 had the most aggregated evidence of functional importance, suggesting their essential roles in cognition and bipedalism.Conclusions Our findings suggest that a small subset of human-specific mutations have contributed to human speciation through impacts on post-transcriptional modification of critical brain-related genes.…”
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Clinico¬pathological features and phylogenetic analysis of rabies infection in local Iraqi breed cattle by M. H. Hussain, Kh. A. Mansour, S. A. A. Al-Redah, A. J. Abid

“…The study showed that the most common clinical signs in the affected animals were behavioural changes (30% of all cattle), followed by a fever (25%), and ataxia (16%). The rest of the clinical signs appeared in varying proportions. …”

Posterior reversible encephalopathy syndrome related to severe hypomagnesaemia by Martín Naya Rosato, María Luisa Núñez Calvo, Lucía Barrera López

“…Case description: A 65-year-old female with a medical history of smoking, arterial hypertension and dyslipidaemia, was admitted due to dysarthria associated with ataxia, visual disturbances and diarrhoea. The neurological physical examination revealed a mild decreased strength in both legs (4/5), mild dysdiadochokinaesia and mild heel-knee dysmetria. …”
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Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS by Valentina Naef, Devid Damiani, Rosario Licitra, Maria Marchese, Stefania Della Vecchia, Matteo Baggiani, Letizia Brogi, Daniele Galatolo, Silvia Landi, Filippo Maria Santorelli

“…Biallelic mutations in the SACS gene, encoding sacsin, cause early-onset autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disease also characterized by unique and poorly understood retinal abnormalities. …”
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MOG associated autoimmune encephalomyelitis with active disease dynamic in imaging examinations and minimal clinical manifestation by E. Tilindytė, I. Muliuolis, R. Samaitienė

“…Progressive encephalopathy and multiple focal neurological symptoms are characteristic to this disease: irritability, disturbed consciousness, weakness, sensory disorders, bowel, bladder dysfunction, spasticity, hyperreflexia, positive Babinsky reflex, paresis, cerebral ataxia, cerebral neuropathy, and spinal cord dysfunction (transverse myelitis). …”
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Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study by Marisol Peña Sánchez, Gabriel Andrés Peña de los Santos, Gretel Riverón Forment, Gloria Lara Fernández, Tatiana Acosta Sánchez, Alina González-Quevedo Monteagudo

“…<br /><strong>Methods:</strong> an analytical, retrospective and case-control study was carried out (Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia type 2 and ischemic stroke: acute and chronic stage). …”
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Extensive Growth of an Anaplastic Meningioma by Hajrullah Ahmeti, Homajoun Maslehaty, Athanasios K. Petridis, Alexandros Doukas, Mehran Mahvash, Harald Barth, H. M. Mehdorn

“…Neuroimaging revealed an extensive growing, contrast enhancing lesion expanding at the supra- and infratentorial convexity, infiltrating and destroying large parts of the skull, and infiltrating the skin. Due to progressive ataxia and dysarthria with proven tumor growth in the posterior fossa in the continuing course, parts of the tumor were resected. …”
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