Asymmetric synthesis of stereogenic-at-iridium(III) complexes through Pd-catalyzed kinetic resolution by Yun-Peng Chu, Xue-Lin Yue, De-Hai Liu, Chuanyong Wang, Jiajia Ma

Get full text

Flow chemistry-enabled asymmetric synthesis of cyproterone acetate in a chemo-biocatalytic approach by Yajiao Zhang, Minjie Liu, Xianjing Zheng, Liang Gao, Li Wan, Dang Cheng, Fener Chen

“…Herein, we report the 10-step chemo-biocatalytic continuous flow asymmetric synthesis of cyproterone acetate (4) in which 10 transformations are combined into a telescoped flow linear sequence from commercially available 4-androstene-3, 17-dione (11). …”
Get full text

Asymmetric synthesis of atropisomers featuring cyclobutane boronic esters facilitated by ring-strained B-ate complexes by Yu-Wen Sun, Jia-Hui Zhao, Xin-Yu Yan, Chong-Lei Ji, Huangdi Feng, De-Wei Gao

“…In this study, we develop an asymmetric synthesis of atropisomers featuring cis-cyclobutane boronic esters facilitated by 1,2-carbon or boron migration of ring-strained B-ate complexes, achieving high enantioselectivity. …”
Get full text

The need for Open Labs for fostering interdisciplinarities in Modern Chemistry. Biocatalysis: a necessary tool for synthetic chemists by Martin, Juliette

Subjects: Get full text

Enantioselective Synthesis of Antiepileptic Drug: (-)-Levetiracetam—Synthetic Applications of the Versatile New Chiral N-Sulfinimine by K. Chandra Babu, R. Buchi Reddy, E. Naresh, K. Ram Mohan, G. Madhusudhan, K. Mukkanti

“…We report an asymmetric synthesis of (-)-Levetiracetam (1) in six steps starting from versatile new chiral N-sulfinimine (3). …”
Get full text

A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols by Sheng Xu, Yuanyuan Ping, Yinyan Su, Haoyun Guo, Aowei Luo, Wangqing Kong

“…However, their synthesis relies on the use of toxic or expensive metal catalysts or suffer from low regioselectivity. Catalytic asymmetric synthesis of optically pure 1,n-diols from bulk chemicals in a highly stereoselective and atom-economical manner remains a formidable challenge. …”
Get full text

Iron-catalysed stereoselective NH transfer enables dynamic kinetic resolution of sulfoxides by Fang-Xu Fan, Hui Xu, Shi-Xiong Tang, Yanfeng Dang, Fei Wang

“…We report here an iron-catalysed stereoselective NH imidation of sulfoxide, which is integrated with photocatalytic racemisation of sulfoxide, enabling a dynamic kinetic resolution (DKR) strategy for direct and asymmetric synthesis of NH-sulfoximines. This approach is distinct from the existing methods by avoiding protecting group manipulations and/or the use of chiral substrates. …”
Get full text

Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules by Shengli Huang, Haojun Wen, Yige Li, Wenling Qin, Pengfei Wang, Yu Lan, Shiqi Jia, Hailong Yan

“…Although progress occurs in the catalytic asymmetric synthesis of helicene (-like) molecules, the enantioselective synthesis of multiple helicenes, especially four or higher helicity, is still challenging and has yet to be achieved. …”
Get full text

Two decades of fluorine chemistry in Cergy by Pytkowicz, Julien, Chaume, Grégory, Lensen, Nathalie, Chelain, Evelyne, Brigaud, Thierry

“…We propose in this review an overview of our contributions to organofluorine chemistry in connection with biological applications and also asymmetric synthesis these past twenty years in Université de Cergy-Pontoise (now CY Cergy Paris Université).…”
Get full text

An unusual chiral-at-metal mechanism for BINOL-metal asymmetric catalysis by Zhenxing Li, Pengfei Chen, Zhigang Ni, Liuzhou Gao, Yue Zhao, Ranran Wang, Congqing Zhu, Guoqiang Wang, Shuhua Li

“…Abstract Chiral binaphthols (BINOL)-metal combinations serve as powerful catalysts in asymmetric synthesis. Their chiral induction mode, however, typically relies on multifarious non-covalent interactions between the substrate and the BINOL ligand. …”
Get full text

Total synthesis and target identification of marine cyclopiane diterpenes by Tian Li, Shan Jiang, Yuanhao Dai, Xia Wu, Huihui Guo, Liang Shi, Xueli Sang, Li Ren, Jie Wang, Lili Shi, Wenming Zhou, Houhua Li, Hong-Dong Hao

“…Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. Our asymmetric synthesis commences from Wieland-Miescher ketone and features a sequential intramolecular Pauson-Khand reaction and gold-catalyzed Nazarov cyclization to rapidly construct the 6-5-5-5 tetracyclic skeleton. …”
Get full text