Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, and DNA methylation profiling, to investigate the response of a representative panel of GBM patient-derived cancer stem cells (CSCs) to astrocytic differentiation and RT and TMZ treatments. …”
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The link between spreading depolarization and innate immunity in the central nervous system by Kadir Oguzhan Soylu, Muge Yemisci, Hulya Karatas

“…Furthermore, the interplay between neurons and glial cells, particularly astrocytes and microglia, underscores the intricate nature of neuroinflammation triggered by SD. …”
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Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for... by Eun Hee Ahn, Jae-Bong Park

“…Other brain cells, such as astrocytes, microglia, and oligodendrocytes, also depend on specific cytoskeletal structures to maintain their unique cellular architectures. …”
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Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival by Ying-Tso Chen, Shu-Shong Hsu, Chi-Man Yip, Ping-Hong Lai, Huai-Pao Lee

“…A primary brain tumor with both astrocytic differentiation and neuronal immunophenotype features is rare. …”
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MAP4 kinase-regulated reduced CLSTN1 expression in medulloblastoma is associated with increased invasiveness by Ece Sönmez, Shen Yan, Meng-Syuan Lin, Martin Baumgartner

“…Co-culture of tumor cells with astrocytes increased CLSTN1 localization in cell-cell contacts, which was further enhanced by MAP4K inhibition. …”
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Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction by Olga I. Rudko, Artemii V. Tretiakov, Elena A. Naumova, Eugene A. Klimov

“…Among three PPAR isoforms, PPARG demonstrates the highest expression in CNS, where it can be found in neurons, astrocytes, and glial cells. Herein, the highest PPARG expression occurs in amygdala. …”
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Research Progress on the Mechanism of Acupuncture Treatment of Ischemic Stroke Based on the Space Construction of Nerve-vascular Unit by LI Mengxing, WNAG Yu, LI Zhen, LIU Fang, SHI Kejian

“…It could also regulate the energy metabolism of astrocytes, inhibit excitatory toxicity and inflammatory response, and coordinate the interaction among neurons, BMEC and glial cells based on the bidirectional regulation effect. …”
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New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Ant... by Nafiseh Pakravan, Ardeshir Abbasi, Zuhair Mohammad Hassan

“…Inflammatory microglia and astrocytes along with abnormal lymphatics associated with insufficient clearance of Aβ and other toxicants from the brain establish a chronic inflammation. …”
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Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients by Walter Taal, Bart Zick, Bart J. Emmer, Martin J. van den Bent

“…Twelve glioma-like lesions in 11/182 patients were resected or biopsied, and histology showed gliomas of astrocytic origin (WHO grade 1–4). <b>Conclusions:</b> It was concluded from these data that asymptomatic glioma-like lesions on MRI brain scans in neurofibromatosis type 1 patients, either with contrast enhancement and/or mass effect, had an indolent nature. …”
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Glymphatic dysfunction and neurodegeneration in ALS: Longitudinal insights from rNLS8 TDP-43 mice by Akram Zamani, Adam K. Walker, David K. Wright

“…Glymphatic flow is facilitated by aquaporin-4 (AQP4) water channels polarized to astrocytic end feet. We found that while glymphatic function normalized to control levels at 7-days post-Dox, AQP4 expression in the cortex was significantly decreased. …”
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Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis by Yajun Deng, Liang Yang, Qiqi Xie, Fengbiao Yang, Guoqiang Li, Guangzhi Zhang, Shaoping Li, Zuolong Wu, Jing Wang, Xuewen Kang

“…PKA colocalized with neurons, astrocytes, and microglia, and apoptotic cells were mainly neurons. …”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…While assessed in neurons, astrocytes, and microglia, its role is far less investigated in myelinating glia, including Schwann cells (SCs), responsible for peripheral nerve myelination. …”
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Adult Human Multipotent Neural Cells Could Be Distinguished from Other Cell Types by Proangiogenic Paracrine Effects via MCP-1 and GRO by Sung Soo Kim, Hee-Jang Pyeon, Yoon Kyung Bae, Hyun Nam, Chung Kwon Kim, Sun-Ho Lee, Kyeung Min Joo

“…They show multipotent differentiation potentials into neurons and astrocytes. In addition, they possess proangiogenic capacities. …”
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Thy1-YFP: an effective tool for single cell tracing from neuronal progenitors to mature functionally active neurons by Ante Plećaš, Katarina Kapuralin, Leonarda Grandverger, Dinko Mitrečić, Ivan Alić

“…The neural stem cells were isolated from embryos at embryonic day 14.5 as well as newborn pups and differentiated into neurons and astrocytes. Our data showed a significant decrease of neural stem cells markers and a substantial increase in neuronal markers during differentiation, analysed by immunocytochemistry, quantitative PCR and western blot. …”
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Neuroprotective Effect of Wharton’s Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neu... by Zohre Aghaei, Narges Karbalaei, Mohammad Reza Namavar, Masoud Haghani, Mahboobeh Razmkhah, Mahdi Khorsand Ghaffari, Marzieh Nemati

“…Reduced TNF-α and enhanced Bcl-2 gene expression levels and elevated neuronal and nonneuronal (astrocytes and oligodendrocytes) cells were detected in the hippocampus of WJMSC-CM-treated diabetic rats. …”
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Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions by Yu Du, Yufei Song, Xiaojie Zhang, Yan Luo, Wenying Zou, Jiawei Zhang, Jianliang Fu

“…After four weeks of BCAS, wild-type mice showed significant working memory deficits, WMLs, activation of microglia and astrocytes, decrease in the number of oligodendrocytes, downregulation of myelin basic protein expression, and increase in the expression of TNF-α and IL-1β; however, four weeks of BCAS failed to induce significant changes in the LepR-deficient db/db mice but elevated the production of anti-inflammatory cytokines and activated the M2 microglia. …”
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Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies by Amanda Qarawani, Efrat Naaman, Rony Ben‐Zvi Elimelech, Michal Harel, Shahaf Sigal‐Dror, Tali Ben‐Zur, Tamar Ziv, Daniel Offen, Shiri Zayit‐Soudry

“…Similarly, immunostaining highlighted the modulation of α‐crystallin expression in retinal astrocytes by AT‐MSC‐Exosomes. These results suggest the potential therapeutic relevance of AT‐MSC‐Exosomes in Aβ‐related retinal pathology, offering a promising avenue for future AMD treatment strategies.…”
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ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain Barrier In Vitro by Fuxing Yang, Kai Zhao, Xiufeng Zhang, Jun Zhang, Bainan Xu

“…A contact coculture system using human astrocytes and hCMEC/D3, an immortalized human brain endothelial cell line, was used to mimic BBB in vitro. …”
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Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism by Rocio Diaz Escarcega, Vijay Kumar M. J., Vasilia E. Kyriakopoulos, Guadalupe J. Ortiz, Aaron M. Gusdon, Huihui Fan, Pedram Peesh, Maria P. Blasco Conesa, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Stella H. Kim, Miriam Hinojosa, Christine M. Farrell, Sean P. Marrelli, Akihiko Urayama, Bhanu P. Ganesh, Paul E. Schulz, Louise D. McCullough, Andrey S. Tsvetkov

“…Conversely, specific dicarboxylic fatty acids were lower in female MCI subjects than male MCI subjects. In cultured astrocytes, 1-arachidonoyl glycerol promoted phosphorylation of the transcriptional regulator sphingosine kinase 2, which was inhibited by the transient receptor potential vanilloid 1 receptor antagonists, as well as chromatin remodelling. …”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…In vitro, rat brain microvascular endothelial cells and astrocytes were stimulated with serum from the sepsis model rats. …”
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