Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway by Ya-Ni Wang, Ling-Ling Zhang, Xiao-Yun Fan, Sha-Sha Wu, Sheng-Quan Zhang

“…Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. …”
Get full text

Serum levels of soluble CD30 in adult patients affected by atopic dermatitis and its relation to age, duration of disease and Scoring Atopic Dermatitis index by Gabriele Di Lorenzo, Sebastiano Gangemi, Rosaria Alba Merendino, Paola Lucia Minciullo, Serafina Paola Cannavò, Nicola Martinelli, Pasquale Mansueto, Giovanni Battista Rini, Roberto Corrocher, Maria Luisa Pacor

“…These subjects had no history of AD, urticaria or seasonal or perennial rhinitis or asthma, and had negative skin prick test to a panel of allergens.…”
Get full text

YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints by Tuija Väänänen, Anna Koskinen, Erja-Leena Paukkeri, Mari Hämäläinen, Teemu Moilanen, Eeva Moilanen, Katriina Vuolteenaho

“…YKL-40 is associated with tissue injury and inflammation, and consequently to diseases in which these mechanisms lead to tissue degradation, for example, asthma and rheumatoid arthritis. The purpose of the present study was to investigate if YKL-40 is also a significant factor in osteoarthritis (OA) by assessing associations of YKL-40 with mediators related to the pathogenesis of OA: cartilage destructing matrix metalloproteinases (MMPs) and proinflammatory cytokines interleukin-6 (IL-6) and interleukin-17 (IL-17). …”
Get full text

Association Between Walking Speed and Urinary Incontinence in the Older Women. Which Patients Should be Referred to Geriatricians? by Volkan Atmis, Basak Guler

“…Two hundred and fifty-eight (66.32%) had hypertension, 122 (31.36%) had diabetes mellitus, 51 (13.11%) had asthma/Chronic obstructive lung disease, 49 (12.59%) had coronary artery disease and 9 (2.31%) had cerebrovascular disease. …”
Get full text

Eosinofilik Esofagitis by Yusri Dianne Jurnalis, Yorva Sayoeti, Widiasteti Widiasteti

“…It’s correlated with food allergy and atopy condition such as asthma, atopy dermatitis, rhinitis allergic and often in conjunction with Gastroesophageal Reflux Disease ( GERD). …”
Get full text

Cumulative Dispensing of Oral Corticosteroids Over 12 Months in People with COPD by Burge AT, Cox NS, Dal Corso S, Jones AW, Faqih FM, Holland AE

“…This issue is well defined in asthma but is less well understood in COPD. The aim of this study was to examine cumulative OCS dispensed to people with COPD over 12 months.Patients and Methods: This was a secondary analysis of data from two randomised controlled trials involving people with COPD followed up for 12 months following pulmonary rehabilitation. …”
Get full text

Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components by Andres Sánchez, Ricardo Cardona, Marlon Munera, Victor Calvo, Manuela Tejada-Giraldo, Jorge Sánchez

“…Additionally, positive nasal provocation test with one animal increased the risk of atopy and positive nasal provocation test to others animals. Pet ownership or asthma was not associated with increased risk of atopy or positive nasal provocation test. …”
Get full text

Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association... by Tiago Alfaro, Filipe Froes, Cláudia Vicente, Rui Costa, Cristina Gavina, Rui Baptista, António Maio, Saraiva da Cunha, João Sérgio Neves, Pedro Leuschner, Sofia Duque, Paula Pinto

“…Background Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection, hospitalisation and death in adults.Methods Based on evidence regarding the impact of RSV on adult populations at risk for severe infection and the efficacy and safety of RSV vaccines, the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine endorses this position paper with recommendations to prevent RSV-associated disease and its complications in adults through vaccination.Conclusion The RSV vaccine is recommended for people aged ≥50 years with risk factors (chronic obstructive pulmonary disease, asthma, heart failure, coronary artery disease, diabetes, chronic kidney disease, chronic liver disease, immunocompromise, frailty, dementia, and residence in a nursing home) and all persons aged ≥60 years. …”
Get full text

Polarization of ILC2s in Peripheral Blood Might Contribute to Immunosuppressive Microenvironment in Patients with Gastric Cancer by Qingli Bie, Pan Zhang, Zhaoliang Su, Dong Zheng, Xinyu Ying, Yumin Wu, Huijian Yang, Deyu Chen, Shengjun Wang, Huaxi Xu

“…Newly identified nuocytes or group 2 innate lymphoid cells (ILC2s) play an important role in Th2 cell mediated immunity such as protective immune responses to helminth parasites, allergic asthma, and chronic rhinosinusitis. However, the contributions of ILC2s in the occurrence and development of cancer remain unknown. …”
Get full text

Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ by Imtiaz Ahmad, Maruful Hasan, Dipty Rani Bhowmik, Rahima Begum, Sourav Roy, Md Monirul Islam, Md Abdur Rahman Ripon, Mohammad Salim Hossain

“…Obesity is a worldwide problem linked to several lifestyle disorders like diabetes, hypertension, heart failure, dyslipidaemias, asthma, etc. Finding a cure for obesity and its consequences is essential. …”
Get full text

Impact of the COVID-19 pandemic on the volume and diagnoses of patients admitted to the paediatric emergency department: a retrospective analysis from a third-level hospital in Nor... by Paulina Blanco-Murillo, Ricardo J Estrada-Mendizabal, Katheryne Paola Madrazo-Aguirre, Manuel Guillermo Ruelas-Martinez, Lucia Escobedo-Berumen, Rommy Elizabeth Pineda-Magaña, Maria Guadalupe Garcia-Lima, Oscar Tamez-Rivera

“…The percentage of infectious diseases decreased from 45.7% to 19.3% (p<0.001), and respiratory diseases from 4.3% to 1.9% (p<0.001), including asthma exacerbations (3.1%–1.5%, p=0.012). There was an increase in the percentage of patients admitted due to accidents (6.6%–14.7%, p<0.001).Conclusions A significant decrease in the total volume of patients, especially those who were admitted due to infectious and respiratory diseases, was documented. …”
Get full text

Impact of multimorbidity and complex multimorbidity on mortality among older Australians aged 45 years and over: a large population-based record linkage study by Alamgir Kabir, An Tran, Sameera Ansari, Damian P Conway, Margo Barr

“…Eleven self-reported chronic conditions (cancer, heart disease, diabetes, stroke, Parkinson’s disease, depression/anxiety, asthma, allergic rhinitis, hypertension, thrombosis and musculoskeletal conditions) from the baseline survey were included in the MM and CMM classifications. …”
Get full text

Cost of Serum Versus Skin Allergy Testing Among Medicare Fee-for-Service Beneficiaries in the United States by Kenny Y. Kwong, Yang Z. Lu

“…Beneficiaries with any sIgE test, skin prick test, or intradermal skin test associated with ICD-10 codes of allergic rhinitis, asthma, and food allergy were included. Aggregate and per-beneficiary testing cost, number of allergens tested, and number of allergy-related specialist visits incurred were estimated by the testing patterns of sIgE only, skin prick only, intradermal only, skin prick and intradermal, and sIgE plus prick and/or intradermal. …”
Get full text

Impact of gas flaring on acute respiratory distress among pregnant women and newborn babies in Delta State Central Senatorial District, Nigeria by Omatseye Alero Akuirene, John Esimaje Moyegbone, Charity Omoikhekpen Chukumah, Mercy Ebiyemi Kalaroo, Josiah Obaghwerhievwo Adjene, Emmanuel Agbonomhen Agege, Joseph Onyedenyifa Odoko, Ezekiel Uba Nwose

“…Health professional reported that developing severe lung infection, release of black carbon and asthma sufferers were major risk factors to RDS. Conclusion: Findings showed that there was an increased prevalence of RDS among the study sub-population. …”
Get full text

Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

Get full text

“Lung-on-a-chip” as an instrument for studying the pathophysiology of human respiration by Oksana A. Zhukova, Iuliia V. Ozerskaya, Dmitry V. Basmanov, Vsevolod Yu. Stolyarov, Vladimir G. Bogush, Vladimir V. Kolesov, Kirill A. Zykov, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev

“…Besides the LoC imitating the hematoalveolar barrier, there are modifications for studying the specific pathophysiological processes, for the screening of medicinal products, for modeling specific diseases, for example, lung cancer, chronic obstructive pulmonary disease or asthma. In the present review, we have analyzed the existing types of LoC, the biomaterials used, the methods of detecting molecular processes within the microfluidic devices and the main directions of research to be conducted using the “lung-on-a-chip”.…”
Get full text

Systematic identification of the chemical components of leaves and roots of Didymocarpus heucherifolius Hand.-Mazz. based on UHPLC Q-Exactive Orbitrap MS technology coupled with mo... by Liangyin Shu, Shunli Xiao, Kailin Li, Huibin Luo, Meng Li, Qingrui Yang, Bowen Gao, Jiaxin Li, Fang Yan, Wei Cai

“…Species in this genus have long been used in folk medicine to treat various illnesses, including wounds, kidney stones, inflammations, asthma, influenza, etc. However, there are few studies on chemical components. …”
Get full text

Adherence to Mediterranean-Like Dietary Pattern in Association with Gastroesophageal Reflux Disease in Adolescents by Azam AhmadiVasmehjani, Sara Beigrezaei, Zahra Nafei, Nasrin Behniafard, Zahra Darabi, Amin Salehi-Abargouei, Majid Aflatoonian

“…Dietary intake was assessed using a food frequency method which included in a reliable and valid Global Asthma Network (GAN) core questionnaire. GERD symp­toms and the frequency of their occurrence over the last week were assessed using a validated GERD questionnaire. …”
Get full text

Hepatitis due to Coxsackie A virus in an adult: a case report by Likith Surendra, Varun Sharma, Milan Sivakumar, Tara Lanzendorf, Thomas C. Varkey, Kaivan Salehpour

“…His past medical history was significant for asthma, chronic back pain taking tramadol, cholecystitis status post cholecystectomy, and an ongoing workup for autoimmune hepatitis. …”
Get full text

Risk of pneumonia in patients with isolated minor rib fractures: a nationwide cohort study by Yu-Hsun Wang, Ming-Chih Chou, Sai-Wai Ho, Ying-Hock Teng, Shun-Fa Yang, Han-Wei Yeh, Chao-Bin Yeh

“…This nationwide cohort study investigated the association between IMRFs and the risk of pneumonia in patients with blunt chest traumas.Design Nationwide population-based cohort study.Setting Patients with IMRFs were identified between 2010 and 2011 from the Taiwan National Health Insurance Research Database.Participants Non-traumatic patients were matched through 1:8 propensity-score matching according to age, sex, and comorbidities (namely diabetes, hypertension, cardiovascular disease, asthma and chronic obstructive pulmonary disease (COPD)) with the comparison cohort. …”
Get full text